Limited Competition: Continuation of the Center for Genomic Studies on Mental Disorders

有限的竞争：精神疾病基因组研究中心的延续

基本信息

批准号：
10378745
负责人：
Linda M Brzustowicz
金额：
$ 975.1万
依托单位：
RUTGERS, THE STATE UNIV OF N.J.
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-07-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10378745
关键词：
Accreditation American Authorization documentation Automation Award Biocompatible Materials Biological Process Biological Products Biological Sciences Biotechnology Blood Blood Cells Budgets California Capital Cell Line Clinical Clinical Data Clinical Distribution Collaborations Collection Communities Complementary DNA Consent Cryopreservation DNA Data Data Collection Data Set Data Storage and Retrieval Databases Deposition Derivation procedure Development Diagnostic Drug Industry Ensure Epigenetic Process Etiology Fee-for-Service Plans Florida Funding Gene Expression Genetic Genetic study Genomics Goals Home Individual Informed Consent Infrastructure Investments Link Lymphocyte Maintenance Manuals Measures Mental disorders Methodology Monitor National Institute of Mental Health New Jersey New York Outcomes Research Pathologist Pennsylvania Pharmacologic Substance Price Privacy Process Production Protocols documentation Publications Quality Control RNA Recovery Research Research Personnel Research Project Grants Research Support Resources Sampling Science Scientist Secure Service provision Services Shipping Somatic Cell System Technology Testing Time Tissue Sample Trust United States Department of Veterans Affairs Universities Veterans Work base biobank bioprocess clinical data repository clinical diagnostics clinical phenotype clinical research site cohort college complex data cost cost effective data archive data curation data dictionary data dissemination data integration data management data resource data sharing design exome experience flexibility genome editing genome-wide genomic data improved induced pluripotent stem cell innovation meetings new technology next generation sequencing novel novel diagnostics novel therapeutic intervention phenotypic data progenitor programs prospective psychogenetics public repository quality assurance repository sample collection success tool transcriptome transcriptome sequencing volunteer web portal web site whole genome

项目摘要

Project Summary The goal of the NIMH Repository and Genomics Resource (NRGR) is to further the understanding of the genetic and environmental etiologies of mental disorders. The NRGR receives raw biosamples, such as blood, from NIMH-supported research projects. The NRGR processes these samples to DNA, RNA, cDNA, or cell lines, which can then be used for genomic analyses. The NRGR also receives, curates, and harmonizes clinical/phenotypic data for each subject. Results of genomic analyses on samples in the NRGR are either directly deposited in the NRGR or are linked to a deposit in another public repository. After a proprietary period, the clinical data, genomic data, DNA, RNA, cDNA, and cell lines are made available to all NIMH- approved researchers through a secure web portal. This sharing of uniformly processed biological samples and curated clinical and genomic data from many cohorts leverages the NIMH investment in genetic studies. It provides critical research power by making a very large body of data available for study of the genetic bases for individual mental disorders. Since October 1998, >250K subject samples have been submitted to NRGR and >615K DNA and >15K cell lines have been distributed. There have been >1,700 distributions of clinical and genomic data to >1,000 investigators, resulting in >1,000 publications using NRGR samples and data. Starting in 2011, the NRGR has provided in-depth characterization services for induced pluripotent stem cells (iPSC) and their progenitor somatic cells, as well as limited iPSC production. As its guiding aim, the NRGR will continue to innovate in order to serve the scientific needs of NIMH PIs in a flexible and highly accessible manner, while respecting subject confidentiality, informed consent issues, and PI prerogatives.

项目概要 NIMH 存储库和基因组学资源 (NRGR) 的目标是进一步了解精神障碍的遗传和环境病因。 NRGR 接收原始生物样本，例如血液、来自 NIMH 支持的研究项目。 NRGR 将这些样本处理为 DNA、RNA、cDNA 或细胞线，然后可用于基因组分析。 NRGR 还接收、策划和协调每个受试者的临床/表型数据。 NRGR 样本的基因组分析结果是直接存放在 NRGR 中或链接到另一个公共存储库中的存放。拥有专有技术后在此期间，临床数据、基因组数据、DNA、RNA、cDNA 和细胞系可供所有 NIMH- 通过安全门户网站批准研究人员。这种统一处理的生物样本的共享来自许多队列的精选临床和基因组数据利用了 NIMH 在基因研究方面的投资。它通过提供大量数据来研究遗传基础，提供关键的研究力量针对个体精神障碍。自 1998 年 10 月以来，已向 NRGR 提交了超过 25 万个受试者样本且 >615K DNA 和 >15K 细胞系已分发。已有超过 1,700 个临床分布和基因组数据给超过 1,000 名研究人员，从而使用 NRGR 样本和数据发表了超过 1,000 篇出版物。从2011年开始，NRGR为诱导多能干细胞提供深度表征服务 (iPSC) 及其祖体细胞，以及有限的 iPSC 产量。作为其指导目标，NRGR 将继续创新，以灵活且易于访问的方式满足 NIMH PI 的科学需求方式，同时尊重受试者保密性、知情同意问题和 PI 特权。