Center for Genomic Studies on Mental Disorders

精神疾病基因组研究中心

基本信息

批准号：
9251973
负责人：
Linda M Brzustowicz
金额：
$ 102.65万
依托单位：
RUTGERS, THE STATE UNIV OF N.J.
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-04-01 至 2018-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9251973
关键词：
Automation Bioinformatics Biological Process Biology Blood Blood Cells California Cell Line Cells Clinical Clinical Data Clinical Distribution Communities Complementary DNA Contracts DNA DNA Repository Data Data Provenance Data Set Data Storage and Retrieval Databases Development Disease Epigenetic Process Equilibrium Etiology Fee-for-Service Plans Fibroblasts Gene Expression Genetic Genetic Variation Genomics Genotype Goals Grant Health Housing Human Genetics Individual Information Sciences Informed Consent Institutes Instruction Internet Interview Investigation Investments Lymphocyte Maintenance Mental disorders Methodology National Institute of Mental Health Neurons Phenotype Plasma Price Privacy Process Production Publications Quality Control RNA Recovery Research Research Personnel Resource Sharing Resources Rice Sampling Secure Security Services Shipping Ships Somatic Cell Source Stem Cell Research Technology Tissue Sample U-Series Cooperative Agreements Universities Washington base cohort cost data format data integration data management database of Genotypes and Phenotypes design epigenomics exome flexibility genetic analysis genetic pedigree genome-wide genomic data genomic tools improved induced pluripotent stem cell innovation lymphoblast medical schools next generation sequencing novel novel diagnostics novel therapeutic intervention online repository phenotypic data progenitor prospective quality assurance repository sample collection stem cell differentiation success tool transcriptome transcriptomics web site whole genome

项目摘要

DESCRIPTION (provided by applicant): The goal of the NIMH Human Genetics Initiative (HGI) is to further understand the genetic and environmental etiologies of mental disorders. One of the major mechanisms for accomplishing this goal is the NIMH Center for Collaborative Genomics Research on Mental Disorders (the "Center"), which receives raw biosamples such as blood from NIMH PIs. The Center processes samples to DNA, RNA, cDNA or cell lines, which can then be submitted for genomic analyses. Along with biosamples the Center receives clinical/phenotypic data for each subject and, eventually, the results of genomic analyses. After a proprietary period, the clinical data, genomic data, DNA, RNA, cDNA and cell lines are made available to all NIMH-approved researchers through a. secure web site. This sharing of uniformly processed biological samples and clinical and genomic data from many cohorts leverages the NIMH investment in a large number of HGI grants. It provides critical research power by providing a large body of data applicable to investigations on the genetic bases for individual mental disorders. Since October 1998, >147,000 subject samples have been submitted and the Center has distributed >310,000 DNA samples and >9,000 cell lines. There have been >450 distributions of clinical and genotype data to ~340 investigators and >260 publications using these samples and data. Starting in 2011 the Center provided cell line banking and characterization services for induced pluripotent stem cells (iPSC) and their progenitor somatic cells. The Center also develops novel bioinformatics and computational genomics tools and methodologies designed to integrate and analyze large, independent sets of genotypic and phenotypic data while resolving phenotype and/or genotype discrepancies in datasets. As its guiding aim, the Center will continue to innovate in order to serve the scientific needs of NIMH PIs in a flexible and highly accessible manner, while respecting subject confidentiality, informed consent issues and PI prerogatives.

描述（由申请人提供）：NIMH 人类遗传学计划 (HGI) 的目标是进一步了解精神障碍的遗传和环境病因。实现这一目标的主要机制之一是 NIMH 精神疾病基因组学合作研究中心（“中心”），该中心接收原始生物样本，例如来自 NIMH PI 的血液。该中心将样本处理为 DNA、RNA、cDNA 或细胞系，然后提交进行基因组分析。除了生物样本外，该中心还收到每个受试者的临床/表型数据，并最终收到基因组分析结果。经过专有期后，临床数据、基因组数据、DNA、RNA、cDNA 和细胞系可通过 NIMH 批准的所有研究人员获得。安全网站。这种来自许多队列的统一处理的生物样本以及临床和基因组数据的共享利用了 NIMH 在大量 HGI 拨款中的投资。它通过提供大量适用于个体精神障碍遗传基础调查的数据，提供了关键的研究力量。自 1998 年 10 月以来，已提交超过 147,000 个受试者样本，中心已分发超过 310,000 个 DNA 样本和超过 9,000 个细胞系。使用这些样本和数据，已向约 340 名研究人员分发了超过 450 份临床和基因型数据，并发表了超过 260 篇出版物。从 2011 年开始，该中心为诱导多能干细胞 (iPSC) 及其祖体细胞提供细胞系库和表征服务。该中心还开发新颖的生物信息学和计算基因组学工具和方法，旨在整合和分析大量独立的基因型和表型数据，同时解决数据集中的表型和/或基因型差异。中心将以不断创新为指导目标，服务科学发展。以灵活且高度可及的方式满足 NIMH PI 的需求，同时尊重受试者机密性、知情同意问题和 PI 特权。