Neural Computations Underlying Vocal Sensorimotor Transformations

声音感觉运动转换的神经计算

基本信息

批准号：
10378771
负责人：
MICHAEL A LONG
金额：
$ 66.21万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-15 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10378771
关键词：
Acoustics Address Anatomy Behavior Bilateral Biological Models Biology Brain Brain region Communication Communication impairment Complex Cues Electric Stimulation Electrodes Engineering Human Individual Insecta Knowledge Label Laboratories Link Mediating Methods Mission Monitor Motor Motor Cortex Movement Mus Muscimol Muscle Neurobiology Pathway interactions Perception Persons Population Process Production Protocols documentation Publications Research Rodent Role Science Sensory Series Site Speech Stereotyping Stimulus Structure Synapses Testing United States National Institutes of Health Work analytical method behavioral response density design experience experimental study flexibility insight neural circuit neuromechanism nonhuman primate optogenetics orofacial relating to nervous system response role model sensory stimulus social vocalization

项目摘要

Project Summary/Abstract This project aims to investigate the circuit mechanisms enabling an ethologically relevant sensorimotor transformation. Specifically, we characterize the neural basis for rapid vocal exchanges in the singing mouse (Scotinomys teguina), a highly vocal neotropical rodent species capable of producing an audible, stereotyped song. Pairs of S. teguina often precisely coordinate the timing of their vocalizations in a process known as countersinging. In preliminary work, we revealed a short-latency pathway from an orofacial region of motor cortex to the muscles involved in vocal production. In this proposal, we will test the hypothesis that neural dynamics in motor cortex, guided by selective acoustic cues, can modify downstream song production circuits to enable rapid vocal communication across individuals. From these studies, we will perform the first characterization of the circuit mechanisms underlying rapid vocal exchanges in a mammalian model system. In Aim 1, we will characterize the acoustic aspects of song that elicit countersinging behavior. We will examine responses to the playback of a range of natural and synthetic sensory stimuli to test perceptual boundaries and factors leading to vocal responsiveness. In Aim 2, we will use several complementary perturbations to address the role of motor cortex on vocal production and countersinging coordination. In Aim 3, we will use population recordings to examine the responses of cortical neural populations during vocal perception and production. We will then characterize the broader neural circuitry leading to countersinging by uncovering both upstream and downstream synaptic partners.

项目概要/摘要该项目旨在研究实现与行为学相关的感觉运动的电路机制转变。具体来说，我们描述了歌唱中快速声音交流的神经基础小鼠 (Scotinomys teguina) 是一种高发声的新热带啮齿类动物，能够发出可听的、定型歌曲。成对的 S. teguina 在一个过程中经常精确地协调它们发声的时间称为反唱。在初步工作中，我们揭示了从口面部区域开始的短延迟通路运动皮层到参与发声的肌肉。在这个提案中，我们将测试以下假设：运动皮层的神经动力学在选择性声音线索的引导下可以修改下游歌曲生产电路可实现个人之间的快速语音交流。从这些研究中，我们将对快速声音交换背后的电路机制进行首次表征哺乳动物模型系统。在目标 1 中，我们将描述引起反唱行为的歌曲的声学方面。我们将检查对一系列自然和合成感官刺激的播放的反应，以测试感知导致声音反应的界限和因素。在目标 2 中，我们将使用几种互补的扰动来解决运动皮层对发声的作用制作和对唱的协调。在目标 3 中，我们将使用群体记录来检查皮质神经群体的反应在声音感知和产生过程中。然后我们将描述更广泛的神经回路，从而导致通过发现上游和下游突触伙伴来对抗。