Remapping Clinical Neuroscience through Translation and Innovation Training (ReCoNnecT-IT)

通过转化和创新培训重新规划临床神经科学 (ReCoNnecT-IT)

• 批准号: 10207790
• 负责人: Geoffrey Karl Aguirre
• 金额: $ 37.37万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10207790
• 关键词: Clinical; Neurosciences; Training; Translations; innovation

Clinician-scientists are uniquely positioned to ask new and insightful scientific questions inspired by patient observations, yet, they often lack the expertise to be able to translate their observations into carefully designed basic scientific and translational experiments. There are likely many reasons for this, but the most cited barriers are lack of specific training, mentoring, funding, and time. If these barriers could be removed, more clinician-scientists could pursue careers in laboratory-based translational research, thereby helping to reverse the current state of affairs in many neurological disorders, in which basic research is proceeding at an increasingly rapid pace but translational research is lagging, and most patients with neurological disorders are left without preventions, treatments or cures. Here we propose a research training program for MD-PhDs or MDs who have finished their clinical training in a neuroscience-related specialty and are highly motivated to pursue careers as physician-scientists in innovative, laboratory-based translational research in brain diseases. The ReConNecT-IT (Remapping Clinical Neurosciences through Translation and Innovation Training) program consists of intense research training under the close mentoring of 1-2 faculty mentors. Trainees design and conduct independent research projects that they can take with them when they transition to independent support, and upon which they will base their NIH K-award application. Research projects are directed toward the translation of the genetic, molecular and cellular pathophysiology of neurological diseases into strategies for prevention, treatment or cure. Trainees will be encouraged to pursue projects that are collaborative and cross-disciplinary, as this fosters their research development, and linking disciplines helps generate ideas that are novel. Trainees will have access to 20 core faculty and can collaborate with other groups. Trainees will work alongside PhD researchers and participate in journal clubs, lab meetings and basic science seminars. The curriculum includes formal training in experimental design, statistical methodology and quantitative literacy, and well as individualized training on statistical/quantitative methodology by our Director of Statistical Training. Trainees will gain an understanding of critical topics in translational research and how basic research is translated into clinical trials (patient-oriented research) via two specific, semester-long courses. They will gain professional skill and understand career opportunities by participating in workshops on developing a K-award application, grant and scientific writing, pursuing an academic career, job search skills, laboratory and project management, and responsible conduct of research. A unique feature of ReConNecT-IT is that prospective trainees can know of their acceptance before their clinical training ends, allowing them to schedule research into their remaining clinical time, thereby expanding the total amount of research experience they will have before writing a K-award application. The main expected short-term outcome for this program is application for an NIH K award or equivalent grants.

临床医生科学家处于独特的地位，可以在患者观察的启发下提出新的、有洞察力的科学问题，然而，他们往往缺乏专业知识，无法将他们的观察结果转化为精心设计的基础科学和转化实验。造成这种情况的原因可能有很多，但最常见的障碍是缺乏具体的培训、指导、资金和时间。如果这些障碍能够消除，更多的临床科学家可以从事基于实验室的转化研究，从而有助于扭转许多神经系统疾病的现状，即基础研究的进展速度越来越快，但转化研究却进展缓慢。滞后，大多数神经系统疾病患者得不到预防、治疗或治愈。在这里，我们为医学博士-博士或医学博士提出了一项研究培训计划，他们已经完成了神经科学相关专业的临床培训，并且非常有动力在脑疾病的创新、基于实验室的转化研究中追求作为医师科学家的职业生涯。 ReConNecT-IT（通过翻译和创新培训重新映射临床神经科学）计划包括在 1-2 名教师导师的密切指导下进行的密集研究培训。学员设计并开展独立研究项目，当他们过渡到独立支持时，他们可以随身携带这些项目，并以此为基础申请 NIH K 奖。研究项目旨在将神经系统疾病的遗传、分子和细胞病理生理学转化为预防、治疗或治愈的策略。我们将鼓励学员开展协作和跨学科的项目，因为这可以促进他们的研究发展，而学科之间的联系有助于产生新颖的想法。学员将有机会接触 20 名核心教员，并可以与其他小组合作。学员将与博士研究人员一起工作，并参加期刊俱乐部、实验室会议和基础科学研讨会。课程包括实验设计、统计方法和定量素养方面的正式培训，以及由统计培训总监提供的统计/定量方法的个性化培训。学员将通过两门特定的、为期一个学期的课程，了解转化研究的关键主题以及如何将基础研究转化为临床试验（以患者为导向的研究）。他们将通过参加有关开发 K 奖申请、资助和科学写作、追求学术生涯、求职技能、实验室和项目管理以及负责任的研究行为的研讨会来获得专业技能并了解职业机会。 ReConNecT-IT 的一个独特功能是，潜在的受训者可以在临床培训结束之前知道他们的接受情况，从而使他们能够将研究安排在剩余的临床时间中，从而扩大他们在撰写 K 奖之前将拥有的研究经验总量应用。该计划的主要预期短期成果是申请 NIH K 奖或同等补助金。