Remapping Clinical Neuroscience through Translation and Innovation Training (ReCoNnecT-IT)

通过转化和创新培训重新规划临床神经科学 (ReCoNnecT-IT)

• 批准号: 10442741
• 负责人: Geoffrey Karl Aguirre
• 金额: $ 32.77万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10442741
• 关键词: Clinical; Neurosciences; Training; Translations; innovation

Clinician-scientists are uniquely positioned to ask new and insightful scientific questions inspired by patient observations, yet, they often lack the expertise to be able to translate their observations into carefully designed basic scientific and translational experiments. There are likely many reasons for this, but the most cited barriers are lack of specific training, mentoring, funding, and time. If these barriers could be removed, more clinician-scientists could pursue careers in laboratory-based translational research, thereby helping to reverse the current state of affairs in many neurological disorders, in which basic research is proceeding at an increasingly rapid pace but translational research is lagging, and most patients with neurological disorders are left without preventions, treatments or cures. Here we propose a research training program for MD-PhDs or MDs who have finished their clinical training in a neuroscience-related specialty and are highly motivated to pursue careers as physician-scientists in innovative, laboratory-based translational research in brain diseases. The ReConNecT-IT (Remapping Clinical Neurosciences through Translation and Innovation Training) program consists of intense research training under the close mentoring of 1-2 faculty mentors. Trainees design and conduct independent research projects that they can take with them when they transition to independent support, and upon which they will base their NIH K-award application. Research projects are directed toward the translation of the genetic, molecular and cellular pathophysiology of neurological diseases into strategies for prevention, treatment or cure. Trainees will be encouraged to pursue projects that are collaborative and cross-disciplinary, as this fosters their research development, and linking disciplines helps generate ideas that are novel. Trainees will have access to 20 core faculty and can collaborate with other groups. Trainees will work alongside PhD researchers and participate in journal clubs, lab meetings and basic science seminars. The curriculum includes formal training in experimental design, statistical methodology and quantitative literacy, and well as individualized training on statistical/quantitative methodology by our Director of Statistical Training. Trainees will gain an understanding of critical topics in translational research and how basic research is translated into clinical trials (patient-oriented research) via two specific, semester-long courses. They will gain professional skill and understand career opportunities by participating in workshops on developing a K-award application, grant and scientific writing, pursuing an academic career, job search skills, laboratory and project management, and responsible conduct of research. A unique feature of ReConNecT-IT is that prospective trainees can know of their acceptance before their clinical training ends, allowing them to schedule research into their remaining clinical time, thereby expanding the total amount of research experience they will have before writing a K-award application. The main expected short-term outcome for this program is application for an NIH K award or equivalent grants.

临床医生科学家的位置独特，可以提出受患者观察启发的新的和有见地的科学问题，但是，他们通常缺乏能够将其观察结果转化为精心设计的基本科学和翻译实验的专业知识。造成这种情况的原因可能有很多，但是最引用的障碍是缺乏具体的培训，指导，资金和时间。如果可以删除这些障碍，则越来越多的临床医生可以从事基于实验室的转化研究中从事职业，从而有助于扭转许多神经系统疾病中的当前状况，在许多神经系统疾病中，基础研究以越来越快的速度进行，但翻译研究滞后，大多数患有神经系统疾病的患者没有预防，治疗，治疗，治疗，治疗或治疗或疗程。在这里，我们为在与神经科学相关的专业方面完成临床培训的MD-PHDS或MDS的研究培训计划，并具有很高的动力，从而在脑部疾病领域的创新，基于实验室的转化研究中从事医师科学家的职业。 Reconnect-IT（通过翻译和创新培训通过翻译和创新培训重塑临床神经科学）由1-2位教职员工的密切指导下进行了激烈的研究培训。学员在过渡到独立支持时可以设计并进行独立的研究项目，并将其基于其NIH K-award申请。研究项目针对神经系统疾病的遗传，分子和细胞病理生理学的转化为预防，治疗或治愈的策略。将鼓励学员从事协作和跨学科的项目，因为这促进了他们的研究发展，并将学科联系起来有助于产生新颖的思想。学员将可以使用20个核心教师，并可以与其他团体合作。学员将与博士研究人员一起工作，并参加期刊俱乐部，实验室会议和基础科学研讨会。该课程包括实验设计，统计方法论和定量素养方面的正式培训，以及我们的统计培训总监对统计/定量方法的个性化培训。学员将通过两种特定的学期课程将基础研究转化为临床试验（以患者为导向的研究），了解转化研究中的关键主题。他们将通过参与开发K-宣告申请，赠款和科学写作，从事学术职业，求职技能，实验室和项目管理以及负责任的研究的研讨会来获得专业技能并了解职业机会。重新连接的一个独特功能是，准学员可以在临床培训结束之前就知道他们的接受度，从而使他们能够将研究安排到剩余的临床时间中，从而扩大在撰写K-Award应用程序之前将拥有的研究经验的总数。该计划的主要预期短期结果是申请NIH K奖或同等补助金。