Multifunctional dressing for treatment of diabetic wounds

治疗糖尿病伤口的多功能敷料

• 批准号: 10207665
• 负责人: Mehmet Remzi Dokmeci
• 金额: $ 31.56万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10207665
• 关键词: Amputation; Angiogenic Factor; Antibiotics; Bacteria; Bacterial Infections; Bandage; Burn injury; Bypass; Calcium; Cathepsin G; Cell Proliferation; Cell physiology; Cells; Cessation of life; Chronic; Cleaved cell; Collagen; Debridement; Dermal; Devices; Diabetes Mellitus; Diabetic mouse; Dimensions; Disease; Early treatment; Endothelial Cells; Engineering; Environment; Enzymes; Fibroblasts; Financial Hardship; Future; Goals; Growth; Health Care Costs; Healthcare Systems; Hydrogels; Hypertrophic Cicatrix; Hypoxia; Immune; Immune response; Immune system; Impairment; In Vitro; Infection; Infection prevention; Inflammation; Inflammatory; Injury; Mediating; Medical; Metabolic; Microbial Biofilms; Monitor; Morbidity - disease rate; Natural regeneration; Needles; Non-Insulin-Dependent Diabetes Mellitus; Operative Surgical Procedures; Oxygen; Patients; Penetration; Peptides; Peroxides; Physiological; Polymers; Prevalence; Process; Quality of life; Research; Risk; Savings; Scientist; Sepsis; Side; Skin; Societies; Sterile coverings; Stromal Cells; Therapeutic; Tissues; Treatment Effectiveness; Up-Regulation; Vascular Endothelial Growth Factors; Vascularization; Vertebral column; Visit; Water; acute wound; angiogenesis; aqueous; base; chronic wound; clinical practice; comorbidity; controlled release; diabetic patient; diabetic ulcer; diabetic wound healing; effective therapy; enhancing factor; experience; fighting; flexibility; healing; improved; in vivo; individualized medicine; interdisciplinary approach; limb amputation; medical complication; migration; mortality; mouse model; neutrophil; non-diabetic; non-healing wounds; pathogen; prevent; recurrent infection; release factor; reparative process; response; tissue oxygenation; tissue repair; wound; wound bed; wound dressing; wound healing

PROJECT SUMMARY Chronic diabetic wounds (CDW) are one of the most challenging and common medical complications of type-2 diabetes. CDWs are associated with significantly increased costs for healthcare systems and society, decreased quality of life for patients, higher rates of co-morbidities such as recurrent infections and amputations, and an overall dramatically higher mortality rate. The wide prevalence of type-2 diabetes and its constantly increasing impact urgently demand the need for effective treatments aimed at restoring physiological healing of CDWs and preventing associated co-morbidities and mortality. Insufficient skin vascularization and infection inhibit effective healing of CDWs. In non-diabetic injuries, physiologic healing relies on neoangiogenesis and vascularization to restore tissue oxygenation, provide metabolic support to regenerating cells/tissues, and to allow migration of immune cells to counteract pathogens. Instead, in CDWs angiogenesis is impaired resulting in tissue hypoxia, lack of the metabolic support required for tissue repair, and an insufficient immune-response to bacterial infections. These conditions first “lock” CDWs in a chronic inflammatory state unable to progress to tissue repair and second place the patients at risk of sepsis. In severe cases, surgical debridement or limb amputation is the only option for saving patients’ lives. Our hypothesis is that the delivery of VEGF (an angiogenic factor), oxygen combined with on demand release of antibiotics in response to upregulation of neutrophil secretomes can prevent biofilm formation and in turn can reduce the CDW morbidity rate. The goal of this proposal is to engineer bandages containing microneedle arrays that can control release VEGF, oxygen, and can self respond to upregulation of bacteria mediated neutrophil secretomes for inducing healing and avoiding infection.

项目概要 慢性糖尿病伤口 (CDW) 是 2 型糖尿病最具挑战性和最常见的医疗并发症之一 糖尿病与医疗保健系统和社会成本增加有关， 患者的生活质量下降，并发感染等合并症发生率更高 截肢，以及总体死亡率显着升高 2 型糖尿病及其相关疾病的广泛流行。 不断增加的影响迫切需要旨在恢复的有效治疗 CDW 的生理愈合并预防相关的并发症和死亡。 血管化和感染抑制CDW的有效愈合在非糖尿病损伤中，生理愈合。 依靠新生血管生成和血管化来恢复组织氧合，为 再生细胞/组织，并允许免疫细胞迁移以抵抗病原体。 血管生成受损，导致组织缺氧，缺乏组织修复所需的代谢支持， 对细菌感染的免疫反应不足，这些情况首先将CDW“锁定”在慢性病中。 炎症状态无法进展为组织修复，严重时患者面临败血症的风险。 在这种情况下，手术清创或截肢是挽救患者生命的唯一选择。 VEGF（一种血管生成因子）、氧气的输送以及抗生素的按需释放 对中性粒细胞分泌体上调的反应可以防止生物膜形成，进而可以减少 该提案的目标是设计包含微针阵列的绷带。 可以控制 VEGF、氧气的释放，并且可以对细菌介导的上调做出自我反应 中性粒细胞分泌体用于诱导愈合和避免感染。

项目成果

Microneedle arrays for the treatment of chronic wounds.

• DOI: 10.1080/17425247.2020.1819787
• 发表时间: 2020-12
• 期刊: Expert opinion on drug delivery
• 影响因子: 6.6
• 作者: Barnum L;Samandari M;Schmidt TA;Tamayol A
• 通讯作者: Tamayol A

Fibrous Systems as Potential Solutions for Tendon and Ligament Repair, Healing, and Regeneration.

• DOI: 10.1002/adhm.202001305
• 发表时间: 2021-04
• 期刊: Advanced healthcare materials
• 影响因子: 10
• 作者: Rinoldi C;Kijeńska-Gawrońska E;Khademhosseini A;Tamayol A;Swieszkowski W
• 通讯作者: Swieszkowski W

In situ forming microporous gelatin methacryloyl hydrogel scaffolds from thermostable microgels for tissue engineering.

• DOI: 10.1002/btm2.10180
• 发表时间: 2020-09
• 期刊: Bioengineering & translational medicine
• 影响因子: 7.4
• 作者: Zoratto N;Di Lisa D;de Rutte J;Sakib MN;Alves E Silva AR;Tamayol A;Di Carlo D;Khademhosseini A;Sheikhi A
• 通讯作者: Sheikhi A

A Readily Scalable, Clinically Demonstrated, Antibiofouling Zwitterionic Surface Treatment for Implantable Medical Devices.

• DOI: 10.1002/adma.202200254
• 发表时间: 2022-05
• 期刊: ADVANCED MATERIALS
• 影响因子: 29.4
• 作者: McVerry, Brian;Polasko, Alexandra;Rao, Ethan;Haghniaz, Reihaneh;Chen, Dayong;He, Na;Ramos, Pia;Hayashi, Joel;Curson, Paige;Wu, Chueh-Yu;Bandaru, Praveen;Anderson, Mackenzie;Bui, Brandon;Sayegh, Aref;Mahendra, Shaily;Di Carlo, Dino;Kreydin, Evgeniy;Khademhosseini, Ali;Sheikhi, Amir;Kaner, Richard B.
• 通讯作者: Kaner, Richard B.

Smart Bandages: The Future of Wound Care.

• DOI: 10.1016/j.tibtech.2018.07.007
• 发表时间: 2018-12
• 期刊: Trends in biotechnology
• 影响因子: 17.3
• 作者: Derakhshandeh H;Kashaf SS;Aghabaglou F;Ghanavati IO;Tamayol A
• 通讯作者: Tamayol A