Social Preference System and Social Cognition in Schizophrenia

精神分裂症的社会偏好系统和社会认知

基本信息

批准号：
8773546
负责人：
Junghee Lee
金额：
$ 15.75万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-01 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8773546
关键词：
Affect Age Area Basic Science Behavioral Behavioral Sciences Brain Clinical Cognition Cognitive Cognitive deficits Complement Cues Data Development Disease Empathy Face Functional Magnetic Resonance Imaging Functional disorder Goals Human Impaired cognition Impairment Individual Interpersonal Relations Intervention Literature Measures Mental disorders National Institute of Mental Health Newborn Infant Patient Self-Report Patients Performance Prefrontal Cortex Process Psyche structure Quality of life Questionnaires Reporting Research Research Domain Criteria Rewards Role Schizophrenia Social Development Stimulus Strategic Planning Superior temporal gyrus Symptoms System Testing arm base experience gaze improved information processing insight mental state neural circuit neuroimaging novel preference public health relevance relating to nervous system skills social social cognition

项目摘要

DESCRIPTION (provided by applicant): Impairment in social cognition- the mental abilities involved in adaptive interpersonal interactions-is increasingly being recognized as a key feature of schizophrenia (SZ). Social cognitive impairment in SZ is pervasive and contributes significantly to poor functioning and overall quality of life. However, despite a growing body of literature, there is no overarching framework to satisfactorily explain the impairment seen in SZ across multiple social cognitive domains (e.g., facial affect recognition, mental state attribution. Identifying such a framework would substantially improve our understanding of the disease and could be valuable for the development of novel interventions to improve social cognition in SZ. With this as the long-term research goal, this exploratory R21 project focuses on a core feature of social information processing, the social preference system (SPS), and will evaluate whether a disrupted SPS is a plausible underlying factor for social cognitive impairment in SZ. The prioritized processing of social information is referred to as the social preference system (SPS). Examples of the SPS include: preferential orienting to social over nonsocial information (i.e., social orienting) and seeking and enjoying social over nonsocial information (i.e., social reward). When processing social information is prioritized, the opportunity to perceive and experience social stimuli and to respond appropriately increases, thereby developing social cognitive skills. Consistent with this view, emerging evidence from basic science strongly supports the critical role of the SPS in the development of social cognition. Further, unique neural areas associated with the SPS have recently been identified. Overall a disrupted SPS is a plausible explanation of social cognitive impairment in SZ. To empirically examine this possibility, we hypothesize that SZ patients have a disrupted SPS and that the downstream effect of this disruption is impaired social cognition, while nonsocial cognition is not affected by the disrupted SPS. With 35 SZ patients and 35 healthy controls over 2 years, we will employ a multi-modal approach (i.e., performance, neuroimaging and self-report questionnaires) with a focus on social orienting and social reward, and will evaluate the following scientific aims: 1) To examine whether SZ patients show a disrupted SPS and whether the downstream effect of the SPS is present in social cognition but not in nonsocial cognition; and 2) To examine whether SZ patients show aberrant neural activations related to the SPS. The findings of this project could be valuable for determining the underlying causes of social cognitive impairment in SZ and could provide insights into our understanding of social cognitive impairment in other psychiatric illnesses. In this regard, this project is consistent with the NIMH Strategic Plan I Objective 1: Promote Discovery in the Brain and Behavioral Science to Fuel Research on the Causes of Mental Disorders and with the NIMH Research Domain Criteria (RDoC) Project.

描述（由申请人提供）：社会认知（参与适应性人际互动的心理能力）受损越来越被认为是精神分裂症（SZ）的一个关键特征。深圳的社会认知障碍很普遍，严重影响了功能和整体生活质量。然而，尽管文献数量不断增加，但仍然没有一个总体框架能够令人满意地解释精神分裂症在多个社会认知领域（例如面部情感识别、精神状态归因）中所见的损害。识别这样的框架将大大提高我们对该疾病的理解以此作为长期研究目标，这个探索性的 R21 项目重点关注社会信息处理的核心特征，即社会偏好系统。 (SPS)，并将评估 SPS 中断是否是 SZ 社会认知障碍的潜在因素。社会信息的优先处理被称为社会偏好系统 (SPS)。 SPS 的示例包括：优先定向。社交信息优于非社交信息（即社交导向），以及寻求和享受社交信息而非非社交信息（即社交奖励）。当优先处理社交信息时，感知和体验社交刺激并做出适当反应的机会就会增加，从而发展社交认知技能。与这一观点一致的是，来自基础科学的新证据有力地支持了 SPS 在社会认知发展中的关键作用。此外，最近还发现了与 SPS 相关的独特神经区域。总体而言，SPS 紊乱是深圳社会认知障碍的合理解释。为了实证检验这种可能性，我们假设 SZ 患者的 SPS 受到破坏，这种破坏的下游影响是社会认知受损，而非社会认知则不受 SPS 破坏的影响。我们将在 2 年内对 35 名 SZ 患者和 35 名健康对照进行研究，采用多模式方法（即表现、神经影像学和自我报告问卷），重点关注社会导向和社会奖励，并将评估以下科学目标： 1）检查SZ患者是否表现出SPS紊乱，以及SPS的下游效应是否存在于社会认知中，但不存在于非社会认知中； 2) 检查 SZ 患者是否表现出与 SPS 相关的异常神经激活。该项目的研究结果对于确定深圳社会认知障碍的根本原因可能很有价值，并且可以为我们对其他精神疾病中的社会认知障碍的理解提供见解。在这方面，该项目符合 NIMH 战略计划 I 目标 1：促进大脑和行为科学的发现，以推动精神障碍原因的研究以及 NIMH 研究领域标准 (RDoC) 项目。