Urology Chronic Pelvic Pain Longitudinal Symptom Patterns Study

泌尿科慢性盆腔疼痛纵向症状模式研究

• 批准号: 10206103
• 负责人: Karl J Kreder
• 金额: $ 14.58万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10206103
• 关键词: Biological; Chronic; Chronic Fatigue Syndrome; Chronic Prostatitis; Clinical; Clinical Research; Clinical Trials Design; Data; Data Analyses; Enrollment; Epidemiology; Etiology; Event; Fibromyalgia; Funding; Goals; Individual; Interstitial Cystitis; Iowa; Irritable Bowel Syndrome; Manuscripts; Measurement; Measures; Michigan; National Institute of Diabetes and Digestive and Kidney Diseases; Natural History; Pain; Pain Disorder; Participant; Pattern; Persons; Phase; Phenotype; Physiological; Preparation; Protocols documentation; Research; Research Personnel; Risk Factors; Site; Symptoms; System; Time; Universities; Urology; Washington; Woman; chronic painful condition; chronic pelvic pain; clinically relevant; design; epidemiologic data; follow-up; improved; insight; interdisciplinary approach; men; participant enrollment; patient subsets; recruit; response; symptom management; treatment response; trend; urologic; urologic chronic pelvic pain syndrome

PROJECT SUMMARY/ABSTRACT Urologic Chronic Pelvic Pain Syndrome (UCPPS) encompasses two highly prevalent chronic urologic pain disorders, interstitial cystitis/ bladder pain syndrome (IC/BPS) in men and women, and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in men. Like many chronic pain disorders, UCPPS is poorly understood and characterized, and treatment is mostly empirical and unsatisfactory. The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network was established by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), to study the etiology and treated natural history of UCPPS, to inform better treatments and management of symptoms through improved designs of clinical trials, and to identify clinical factors and research measurements to define clinically relevant sub-groups of these patients. The MAPP Research Network is currently completing enrollment of participants into the Trans-MAPP Symptom Patterns Study (SPS), which involves integrated phenotyping of UCPPS participants at baseline and during a 36-month longitudinal, observational period. The SPS includes measures to refine UCPPS subgrouping, identify symptom trends, and discover associated risk factors and biological correlates to progression profiles. Integrated within the central protocol are studies to correlate clinical and biological profiles with response to selected UCPPS therapies (the Analysis of Therapies during Longitudinal Assessment of Symptoms [ATLAS] study). The current funding period ends in June 2019. We propose a three-year funding extension, through June 2022. During the proposed three-year extension, we aim to accomplish the following: SPECIFIC AIM 1: To Obtain an Additional 12 Months of Follow-up in the MAPP-II SPS. The MAPP-II SPS was designed to follow UCPPS participants for up to three years. By extending the timeframe for longitudinal follow-up from July 2019 to July 2020, the number of UCPPS participants followed for three years in the SPS will almost double (from 198 to 384). This additional data will substantially increase the ability of MAPP investigators to examine patterns and predictors of UCPPS symptoms over time. SPECIFIC AIM 2: To Observe Additional ATLAS Events in the MAPP-II SPS. A major focus of the MAPP-II SPS is to correlate individual participant phenotypes with UCPPS treatment response. To accomplish this, SPS participants complete a phenotyping assessment before and after starting new UCPPS treatments (ATLAS study). The additional year of follow-up will provide time for new treatment `events' to occur which can be included in this important analysis. SPECIFIC AIM 3: To Conduct Analyses of MAPP-II Data. The current funding period provides inadequate time for MAPP investigators to analyze the data collected as part of the SPS. Therefore, the final two years of the proposed three-year MAPP-II extension will be devoted exclusively to data analysis and manuscript preparation.

项目摘要/摘要 泌尿科慢性骨盆疼痛综合征（UCPPS）包括两个高度普遍的慢性泌尿科疼痛 男性和女性的疾病，间质性膀胱炎/膀胱疼痛综合征（IC/ bps）和慢性 男性的前列腺炎/慢性骨盆疼痛综合征（CP/CPP）。像许多慢性疼痛障碍一样，UCPP是 理解和表征不足，而治疗主要是经验和不令人满意的。这 慢性骨盆疼痛研究（MAPP）研究网络的多学科方法是由 美国国家糖尿病与消化和肾脏疾病（NIDDK）研究病因和病因学和 治疗UCPP的自然历史，以改善症状的更好治疗和管理 临床试验的设计，并确定临床因素和研究测量以定义临床相关的 这些患者的子组。 MAPP研究网络目前正在完成参与者的入学式跨MAPP症状 模式研究（SPS），涉及在基线和在A期间对UCPPS参与者进行集成的表型 36个月的纵向，观察期。 SPS包括完善UCPP子组的措施， 确定症状趋势，发现相关的危险因素和生物学与进展概况相关。 集成在中央协议中的是将临床和生物学特征与回应相关的研究 选定的UCPPS疗法（症状纵向评估期间的疗法分析[ATLAS] 学习）。当前的资金期限于2019年6月结束。我们提出了为期三年的资金延长， 到2022年6月。在拟议的三年延长期间，我们旨在完成以下内容： 具体目标1：在MAPP-II SPS中再进行12个月的随访。 mapp-ii sps 旨在跟随UCPPS参与者长达三年。通过延长纵向时间表 从2019年7月到2020年7月的随访，UCPPS参与者的数量在SPS中进行了三年 将几乎翻一番（从198到384）。这些附加数据将大大提高MAPP的能力 研究人员会随着时间的流逝检查UCPP症状的模式和预测因子。具体目标2： 观察MAPP-II SPS中的其他Atlas事件。 MAPP-II SPS的主要重点是关联 具有UCPPS治疗反应的个体参与者表型。为此，SPS参与者 在开始新的UCPPS治疗（ATLAS研究）之前和之后，完成表型评估。这 额外的随访年将为新的治疗“事件”提供时间，可以包含在此中 重要分析。特定目的3：进行MAPP-II数据的分析。当前的资金期 MAPP研究人员提供了不足的时间来分析作为SPS一部分收集的数据。所以， 提议的三年MAPP-II扩展的最后两年将专门用于数据分析 和手稿准备。

项目成果

Sub-noxious Intravesical Lipopolysaccharide Triggers Bladder Inflammation and Symptom Onset in A Transgenic Autoimmune Cystitis Model: A MAPP Network Animal Study.

• DOI: 10.1038/s41598-018-24833-x
• 发表时间: 2018-04-26
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Kogan P;Xu S;Wang Y;O'Donnell MA;Lutgendorf SK;Bradley CS;Schrepf A;Kreder KJ;Luo Y
• 通讯作者: Luo Y

Assessment of the Lower Urinary Tract Microbiota during Symptom Flare in Women with Urologic Chronic Pelvic Pain Syndrome: A MAPP Network Study.

泌尿科慢性盆腔疼痛综合征女性症状发作期间下尿路微生物群的评估：MAPP 网络研究。

• DOI: 10.1016/j.juro.2015.09.075
• 发表时间: 2016-02
• 期刊: The Journal of urology
• 作者: Nickel JC;Stephens A;Landis JR;Mullins C;van Bokhoven A;Lucia MS;Ehrlich GD;MAPP Research Network
• 通讯作者: MAPP Research Network

Cognitive-behavioral stress management reverses anxiety-related leukocyte transcriptional dynamics.

• DOI: 10.1016/j.biopsych.2011.10.007
• 发表时间: 2012-02-15
• 期刊: BIOLOGICAL PSYCHIATRY
• 影响因子: 10.6
• 作者: Antoni, Michael H.;Lutgendorf, Susan K.;Blomberg, Bonnie;Carver, Charles S.;Lechner, Suzanne;Diaz, Alain;Stagl, Jamie;Arevalo, Jesusa M. G.;Cole, Steven W.
• 通讯作者: Cole, Steven W.

Search for Microorganisms in Men with Urologic Chronic Pelvic Pain Syndrome: A Culture-Independent Analysis in the MAPP Research Network.

• DOI: 10.1016/j.juro.2015.01.037
• 发表时间: 2015-07
• 期刊: JOURNAL OF UROLOGY
• 影响因子: 6.6
• 作者: Nickel, J. Curtis;Stephens, Alisa;Landis, J. Richard;Chen, Jun;Mullins, Chris;van Bokhoven, Adrie;Lucia, M. Scott;Melton-Kreft, Rachael;Ehrlichk, Garth D.
• 通讯作者: Ehrlichk, Garth D.

Changes in symptoms during urologic chronic pelvic pain syndrome symptom flares: findings from one site of the MAPP Research Network.

泌尿科慢性盆腔疼痛综合征症状发作期间症状的变化：来自 MAPP 研究网络一个站点的发现。

• DOI: 10.1002/nau.22534
• 发表时间: 2015
• 期刊: Neurourology and urodynamics
• 影响因子: 2
• 作者: Sutcliffe,Siobhan;Colditz,GrahamA;Pakpahan,Ratna;Bradley,CatherineS;Goodman,MelodyS;Andriole,GeraldL;Lai,HHenry
• 通讯作者: Lai,HHenry