Multi-disciplinary Approach to the Study of Chronic Pelvic Pain (MAPP)

慢性盆腔疼痛 (MAPP) 研究的多学科方法

• 批准号: 8334693
• 负责人: Karl J Kreder
• 金额: $ 83.04万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8334693
• 关键词: Address; Adrenal Glands; Animal Model; Applications Grants; Basic Science; Behavioral; Biochemical; Biochemistry; Bladder; Characteristics; Chronic; Chronic Fatigue Syndrome; Chronic inflammatory pain; Clinical; Comorbidity; Corticotropin; Data; Data Analyses; Development; Diagnosis; Disease; Etiology; Exhibits; Expenditure; Feedback; Fibromyalgia; Functional disorder; Glucocorticoid Receptor; Glucocorticoids; Grant; Histamine; Hormones; Hour; Hydrocortisone; Hypothalamic structure; Immunology; In Vitro; Increased frequency of micturition; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; Interleukin-6; Interleukin-8; Interstitial Cystitis; Investigation; Iowa; Irritable Bowel Syndrome; Laboratories; Lymphocyte; Measures; Methylhistamines; Molecular; Nature; Neurons; Neurosecretory Systems; Pain; Pathogenesis; Patients; Pattern; Pelvic Pain; Phase; Phenotype; Physiological; Pituitary Gland; Predisposing Factor; Predisposition; Production; Protocols documentation; Recovery; Regulation; Reporting; Research; Research Personnel; Rest; Rheumatoid Arthritis; Risk Factors; Role; Salivary; Site; Specimen; Stress; Subgroup; Symptoms; Syndrome; System; Testing; Time; Tissues; Tumor Necrosis Factor-alpha; Universities; Vascular Endothelial Growth Factors; Work; base; biological adaptation to stress; chronic pain; chronic pelvic pain; cohort; cytokine; design; hypothalamic-pituitary-adrenal axis; insight; interest; mast cell; neurophysiology; novel; painful bladder syndrome; programs; receptor sensitivity; response; trend; urinary; urologic

DESCRIPTION, OVERALL (provided by applicant): Despite years of research and a considerable monetary expenditure the pathophysiology of the Urologic Chronic Pelvic Pain Syndrome (UCPPS) known as Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS) remains elusive. This University of Iowa MAPP grant proposal is intended to study this condition from a new perspective. The proposal is designed around the general hypothesis that patients with IC/PBS bladder symptoms and a co-morbid condition like fibromyalgia (FM) or irritable bowel syndrome (IBS) have systemic basis for their symptoms and are fundamentally different from patients with IC/PBS bladder symptoms alone. We based our general hypothesis on the previous work of the investigators in this MAPP application which is detailed in subsequent sections. During the program project planning and design phase for the 5 projects proposed in this grant, all investigators worked from this general hypothesis. The proposed work is important because of its novel nature and the synergy and horizontal integration among the 5 proposed projects. The projects were planned to examine the heterogenous condition of IC/PBS. The cohorts of patients to be studied are similar across all clinical projects and include patients with IC/PBS symptoms in the bladder only, patients with IC/PBS bladder symptoms and a systemic co-morbid condition (FM, IBS), patients with only a co-morbid condition (FM.IBS) and healthy controls. The basic science projects reinforce and expand the scope of the clinical projects by utilizing biologic specimens collected in the clinical projects to add basic cellular, molecular and biochemical understanding of the UCPPS syndrome (IC/PBS). The Project proposals examine the UCPPS of IC/PBS from a multifaceted perspective. Subsequent data analysis of this Discovery Site project will describe the phenotype and risk factors of each group related to the HPA axis, stress response, neurophysiology, pain pattern, biologic and behavioral predisposing factors, basic immunology and biochemistry.

描述，总体（由申请人提供）：尽管经过多年的研究和相当大的货币支出，但泌尿科慢性骨盆疼痛综合征（UCPPS）被称为间质膀胱炎/疼痛膀胱炎（IC/PBS）仍然难以捉摸。这项爱荷华大学MAPP赠款提案旨在从新的角度研究这种情况。该提案的设计围绕了一个普遍的假设，即患有IC/PBS膀胱症状的患者和诸如纤维肌痛（FM）或肠易激综合征（IBS）（IBS）的合并症患者具有全身性症状的基础，并且与单独具有IC/PBS膀胱症状的患者根本不同。我们的一般假设基于研究人员在此MAPP应用中的先前工作，该应用程序在随后的部分中详细介绍了。在该赠款中提出的5个项目的计划项目计划和设计阶段中，所有研究人员都从这个一般假设中介入。拟议的工作很重要，因为它的新颖性质以及拟议项目之间的协同作用和水平整合。计划研究IC/PBS的异质状况。在所有临床项目中，要研究的患者队列都相似，包括膀胱中具有IC/PBS症状的患者，IC/PBS膀胱症状的患者和全身性共发生状况（FM，IBS），仅具有联合性疾病（FM.IB）和健康对照的患者。基础科学项目通过利用临床项目中收集的生物标本来增强和扩大临床项目的范围，以增加对UCPPS综合征（IC/PBS）的基本细胞，分子和生化理解的基本理解。项目提案从多方面的角度检查了IC/PBS的UCPP。此发现站点项目的随后数据分析将描述与HPA轴，压力反应，神经生理学，疼痛模式，生物学和行为易感性因素，基本免疫学和生物化学相关的每个组的表型和风险因素。