A new model system for assessing the socio-environmental determinants of the pace of aging: leveraging a long-term study of wild capuchins

评估衰老速度的社会环境决定因素的新模型系统：利用对野生卷尾猴的长期研究

• 批准号: 10696141
• 负责人: Fernando Alonso Campos
• 金额: $ 26.01万
• 依托单位: UNIVERSITY OF TEXAS SAN ANTONIO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10696141
• 关键词: Acceleration; Address; Adrenal Glands; Adult; Age; Aging; Americas; Animal Model; Assessment tool; Back; Behavior assessment; Behavioral; Biological; Biological Aging; Biological Markers; Biological Models; Birth; Brain; Capuchin Monkey; Chronology; Complex; Costa Rica; Data; Data Collection; Data Set; Development; Diet Habits; Dimensions; Droughts; Elderly; Environmental Risk Factor; Epigenetic Process; Female; Fruit; Gait speed; Generations; Geriatric Assessment; Health; Heterogeneity; Human; In Situ; Individual; Individual Differences; Inflammation; Knowledge; Laboratories; Life; Life Cycle Stages; Life Expectancy; Life Experience; Life Style; Link; Literature; Longevity; Longitudinal Studies; Measures; Methods; Mission; Modeling; Molecular; Monitor; Onset of illness; Outcome; Pattern; Personal Satisfaction; Phase; Phenotype; Physical Function; Physical environment; Physiological; Population; Positioning Attribute; Primates; Process; Productivity; Proteome; Public Health; Rain; Research; Sampling; Sex Differences; Social Behavior; Social Environment; Source; Statistical Models; Techniques; Temperature; Testing; United States National Institutes of Health; Variant; Wild Animals; age related; analog; behavior measurement; behavior observation; body system; experience; field study; genetic pedigree; gut microbiome; health assessment; health care availability; health disparity; healthspan; human old age (65+); immune function; individual variation; innovation; insight; intergenerational; life history; longitudinal analysis; longitudinal, prospective study; male; member; molecular domain; nonhuman primate; novel; physical conditioning; population based; social; social adversity; social group; social relationships; socioenvironmental factor; trait; translational study

PROJECT SUMMARY One of the most enduring questions in public health is why some individuals retain good health into old age while others experience declines in health, physical function, and wellbeing. Growing evidence indicates that socio-environmental factors can contribute to individual differences in the progression of ‘biological aging’, yet we lack a clear understanding of how they influence different body systems. Although these questions have been difficult to address in humans, wild populations of primates offer unique opportunities for progress. This project’s overarching objective is to generate new insights into how social and physical environments influence heterogeneity in rates of aging and health disparities. We will accomplish this by developing a new model system for the study of biological aging, using a combination of field-based behavioral observation and laboratory analyses of noninvasive biological samples from wild white-faced capuchins. Our long-term longitudinal study of this species allows us to leverage almost 40 years of granular data on life-histories, pedigrees, and social behavior, as well as a rich assortment of associated data on the physical environment. The traits that capuchins share with humans, including complex social relationships, omnivory, large brains, and extended longevity, make them well-situated to provide insights into aging and health in our own species. Our first Aim for the Development Phase is to identify, validate, and characterize biomarkers of aging and health in physiological and molecular domains from non-invasive biological samples in a cross-section of adult capuchins of known ages (6-27 years). We have been at the forefront of developing cutting-edge techniques for noninvasive biological sampling, through which we will expand the set of wild animal models in which biological aging can be studied. Second, we will develop new behavioral assessments of physical function that are analogs of common geriatric assessments, and quantify aspects of social adversity parallel to those linked to poor health, reduced survival, or accelerated biological aging in humans. In the Implementation Phase, our Aim is to test the contributions of social and physical environments to trajectories of health and aging across the life course, including sex differences in these relationships. To accomplish this, we will analyze longitudinal variation in the biomarkers and health assessments that we establish during the Development Phase, in combination with our long-term contextual data. By the study’s conclusion, we will have established an innovative wild animal model of health and aging, with newly developed biomarkers to track aging processes in an exceptional breadth of different body systems and extended phenotypes. By integrating these new measures with our outstanding long-term data, we will shed new light on potential mechanisms that explain individual differences in the progression of aging, and in doing so, take an important step toward understanding how to extend the years of active, healthy life in humans.

项目摘要 公共卫生中最持久的问题之一是为什么有些人将健康保持良好的健康状态 而其他人则经历健康，身体机能和福祉的下降。越来越多的证据表明 社会环境因素可以导致“生物衰老”进展的个体差异，但 我们对它们如何影响不同的身体系统缺乏明确的了解。尽管这些问题有 在人类中很难解决，野生私人人口为进步提供了独特的机会。 该项目的总体目标是生成有关社会和物理环境如何的新见解 影响衰老和健康差异率的异质性。我们将通过开发新的 研究生物衰老的模型系统，结合了基于现场的行为观察和 对野生白面胶囊的非侵入性生物样品的实验室分析。我们的长期 对该物种的纵向研究使我们能够利用近40年的生命历史数据， 谱系和社会行为以及在物理环境上的相关数据丰富。 胶囊与人类共享的特征，包括复杂的社会关系，杂食，大脑，大脑， 并延长寿命，使其良好的位置，以提供对我们自己物种衰老和健康的见解。 我们的开发阶段的第一个目标是识别，验证和表征衰老的生物标志物和 来自非侵入性生物学样品的物理和分子结构域的健康状况 已知年龄的卷尾卷（6-27岁）。我们一直处于开发尖端技术的最前沿 对于非侵入性生物学采样，我们将扩大一组野生动物模型 生物衰老可以研究。其次，我们将制定对身体机能的新行为评估 是常见老年评估的类似物，并量化与链接的社交广告的各个方面 健康状况不佳，生存率降低或人类加速生物衰老。在实施阶段，我们 目的是测试社会和物理环境对健康和衰老轨迹的贡献 生活课程，包括这些关系中的性别差异。为此，我们将分析纵向 我们在开发阶段建立的生物标志物和健康评估的差异 结合我们的长期上下文数据。 根据研究的结论，我们将建立一种创新的健康和衰老的野生动物模型，并与 新开发的生物标志物可以在不同的身体系统的特殊广度和 扩展表型。通过将这些新措施与我们出色的长期数据相结合，我们将摆脱 对潜在机制的新启示，这些机制解释了衰老进展的个体差异以及 因此，朝着了解如何延长人类积极，健康生活的年份迈出的重要一步。