Cancer Research Informatics Shared Resource Facility

癌症研究信息学共享资源设施

基本信息

批准号：
10204887
负责人：
Eric B. Durbin
金额：
$ 18.02万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-08 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10204887
关键词：
Adopted Appalachian Region Basic Science Big Data Bioinformatics Biometry Cancer Center Cancer Center Support Grant Cancer Control Catchment Area Cellular biology Clinical Clinical Cancer Center Clinical Sciences Clinical Treatment Clinical Trials Collaborations Communities Computational Science Computer software Data Data Reporting Data Set Data Sources Data Storage and Retrieval Databases Development Educational workshop Ensure Epigenetic Process Evaluation Research Faculty Foundations Funding Genomic Instability Goals Grant Healthcare High Performance Computing Human Informatics Information Technology Infrastructure Institutes Kentucky Knowledge Knowledge Discovery Leadership Machine Learning Maintenance Malignant Neoplasms Medicine Mentors Mentorship Metabolism Methods Mission Molecular NCI Center for Cancer Research National Cancer Institute Natural Language Processing Outcome Measure Pathology Patient-Focused Outcomes Patients Peer Review Phenotype Population Research Preparation Research Research Personnel Resource Informatics Resources Role SEER Program Science Scientist Services Signal Transduction Source Supporting Cell Technology Therapeutic Therapeutic Studies Tissue Microarray Training and Education Translational Research Treatment outcome United States Universities analytical method anticancer research biomedical informatics cancer cell cancer genomics cancer prevention clinical center clinical decision support clinical decision-making cohort data dissemination data ecosystem data exchange data management data quality data sharing data standards data warehouse design diverse data drug discovery evidence base genomic biomarker handheld mobile device improved informatics shared resource informatics tool innovation interoperability machine learning method member mortality multidimensional data national surveillance neoplasm registry next generation sequencing novel population based precision medicine programs recruit research and development research data dissemination response screening surveillance data tumor

项目摘要

PROJECT SUMMARY/ABSTRACT The Cancer Research Informatics Shared Resource Facility (CRI SRF) serves as a Markey Cancer Center (MCC)-managed resource that develops and applies informatics methods and technologies to enable the advancement of science through the curation and open investigator access to high quality data from a wide variety of institutional sources. CRI has expanded MCC's data ecosystem to cover MCC's entire catchment area of Kentucky through linkages and integration with high quality population-based data from the Surveillance Epidemiology and End Results (SEER) Kentucky Cancer Registry. Enhanced and expanded through CCSG support and implementing changes recommended from the last CCSG review, the CRI has been highly innovative in the provision of comprehensive informatics services readily available to cancer center investigators. Services are broadly categorized into: 1) provision of integrated data from the patient-centric cancer research data warehouse; 2) research in clinical decision support for MCC's Molecular Tumor Board; 3) high-performance computing (HPC) and big data storage support for bioinformatics analyses and machine learning approaches to natural language processing (NLP); 4) data management to ensure complete and accurate clinical trial and biospecimen data; 5) automated screening of eligible patients for clinical trial recruitment; 6) identification and annotation of human biospecimens; 7) software and database development for research and data dissemination; 8) informatics support for study planning and grant preparation; and 9) mentorship, training and education. CRI services have been utilized by 103 MCC members, 55 of whom (53%) are peer-reviewed funded members. CRI infrastructures and data management applications enable efficient interactions among the Research Programs and other SRFs such as a portal for basic science researchers to access bioinformatics analysis results. CRI develops and supports critical informatics technologies in databases, data warehousing, NLP, deep phenotyping, HPC, mobile device apps, data sharing and data dissemination. CRI closely coordinates the acquisition and provision of institutional informatics resources in collaboration with the University of Kentucky (UK) Institute for Biomedical Informatics, the UK Center for Clinical and Translational Science, UK HealthCare Information Technology and the UK Center for Computational Sciences. CRI has established strategic alliances with informatics centers of excellence and national agencies to enhance Kentucky data and to collaboratively develop informatics tools and data standards serving the greater cancer research community. In addition, CRI faculty and staff serve as national informatics leaders in cancer data exchange standards and innovative software applications adopted across the United States. CRI is led by Dr. Eric B. Durbin (CP) and is tightly integrated with the Biostatistics and Bioinformatics; Biospecimen Procurement and Translational Pathology; and Oncogenomics SRFs through the provision of essential informatics services that enhance the other MCC SRF service offerings.

项目概要/摘要癌症研究信息学共享资源设施 (CRI SRF) 充当马基癌症中心 (MCC) 管理的资源，开发和应用信息学方法和技术，以实现通过管理和开放研究者获取来自广泛领域的高质量数据来推动科学进步各种机构来源。 CRI拓展中冶数据生态，覆盖中冶全流域通过与来自肯塔基州的高质量人口数据的联系和整合流行病学监测和最终结果 (SEER) 肯塔基州癌症登记处。增强和扩展通过 CCSG 的支持和实施上次 CCSG 审查中建议的变更，CRI 已在向癌症中心提供随时可用的综合信息学服务方面具有高度创新性调查人员。服务大致分为：1）提供以患者为中心的综合数据癌症研究数据仓库； 2) MCC分子肿瘤委员会临床决策支持研究； 3）用于生物信息学分析和机器的高性能计算（HPC）和大数据存储支持自然语言处理（NLP）的学习方法； 4）数据管理保证完整和准确的临床试验和生物样本数据； 5）自动筛选符合临床试验资格的患者招聘; 6）人体生物样本的鉴定和注释； 7）软件和数据库开发用于研究和数据传播； 8）为研究计划和资助准备提供信息学支持；和 9) 指导、培训和教育。已有 103 家 MCC 会员使用了 CRI 服务，其中 55 家（53%）是经过同行评审的资助成员。 CRI 基础设施和数据管理应用程序可实现高效研究计划和其他 SRF 之间的互动，例如基础科学研究人员的门户网站访问生物信息学分析结果。 CRI 开发并支持以下领域的关键信息技术：数据库、数据仓库、NLP、深度表型分析、HPC、移动设备应用程序、数据共享和数据传播。 CRI 密切协调机构信息学资源的获取和提供与肯塔基大学（英国）生物医学信息学研究所、英国中心合作临床和转化科学、英国医疗保健信息技术和英国中心计算科学。 CRI 与信息学卓越中心建立了战略联盟，国家机构加强肯塔基州数据并合作开发信息学工具和数据为更大的癌症研究界服务的标准。此外，CRI 的教职员工还担任国家癌症数据交换标准和创新软件应用程序的信息学领导者美国。 CRI 由 Eric B. Durbin 博士 (CP) 领导，与生物统计学和生物信息学；生物样本采购和转化病理学；和肿瘤基因组学 SRF 通过提供必要的信息学服务，以增强 MCC SRF 的其他服务产品。