Cancer Research Informatics Shared Resource Facility

癌症研究信息学共享资源设施

基本信息

批准号：
10204887
负责人：
Eric B. Durbin
金额：
$ 18.02万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-08 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10204887
关键词：
Adopted Appalachian Region Basic Science Big Data Bioinformatics Biometry Cancer Center Cancer Center Support Grant Cancer Control Catchment Area Cellular biology Clinical Clinical Cancer Center Clinical Sciences Clinical Treatment Clinical Trials Collaborations Communities Computational Science Computer software Data Data Reporting Data Set Data Sources Data Storage and Retrieval Databases Development Educational workshop Ensure Epigenetic Process Evaluation Research Faculty Foundations Funding Genomic Instability Goals Grant Healthcare High Performance Computing Human Informatics Information Technology Infrastructure Institutes Kentucky Knowledge Knowledge Discovery Leadership Machine Learning Maintenance Malignant Neoplasms Medicine Mentors Mentorship Metabolism Methods Mission Molecular NCI Center for Cancer Research National Cancer Institute Natural Language Processing Outcome Measure Pathology Patient-Focused Outcomes Patients Peer Review Phenotype Population Research Preparation Research Research Personnel Resource Informatics Resources Role SEER Program Science Scientist Services Signal Transduction Source Supporting Cell Technology Therapeutic Therapeutic Studies Tissue Microarray Training and Education Translational Research Treatment outcome United States Universities analytical method anticancer research biomedical informatics cancer cell cancer genomics cancer prevention clinical center clinical decision support clinical decision-making cohort data dissemination data ecosystem data exchange data management data quality data sharing data standards data warehouse design diverse data drug discovery evidence base genomic biomarker handheld mobile device improved informatics shared resource informatics tool innovation interoperability machine learning method member mortality multidimensional data national surveillance neoplasm registry next generation sequencing novel population based precision medicine programs recruit research and development research data dissemination response screening surveillance data tumor

项目摘要

PROJECT SUMMARY/ABSTRACT The Cancer Research Informatics Shared Resource Facility (CRI SRF) serves as a Markey Cancer Center (MCC)-managed resource that develops and applies informatics methods and technologies to enable the advancement of science through the curation and open investigator access to high quality data from a wide variety of institutional sources. CRI has expanded MCC's data ecosystem to cover MCC's entire catchment area of Kentucky through linkages and integration with high quality population-based data from the Surveillance Epidemiology and End Results (SEER) Kentucky Cancer Registry. Enhanced and expanded through CCSG support and implementing changes recommended from the last CCSG review, the CRI has been highly innovative in the provision of comprehensive informatics services readily available to cancer center investigators. Services are broadly categorized into: 1) provision of integrated data from the patient-centric cancer research data warehouse; 2) research in clinical decision support for MCC's Molecular Tumor Board; 3) high-performance computing (HPC) and big data storage support for bioinformatics analyses and machine learning approaches to natural language processing (NLP); 4) data management to ensure complete and accurate clinical trial and biospecimen data; 5) automated screening of eligible patients for clinical trial recruitment; 6) identification and annotation of human biospecimens; 7) software and database development for research and data dissemination; 8) informatics support for study planning and grant preparation; and 9) mentorship, training and education. CRI services have been utilized by 103 MCC members, 55 of whom (53%) are peer-reviewed funded members. CRI infrastructures and data management applications enable efficient interactions among the Research Programs and other SRFs such as a portal for basic science researchers to access bioinformatics analysis results. CRI develops and supports critical informatics technologies in databases, data warehousing, NLP, deep phenotyping, HPC, mobile device apps, data sharing and data dissemination. CRI closely coordinates the acquisition and provision of institutional informatics resources in collaboration with the University of Kentucky (UK) Institute for Biomedical Informatics, the UK Center for Clinical and Translational Science, UK HealthCare Information Technology and the UK Center for Computational Sciences. CRI has established strategic alliances with informatics centers of excellence and national agencies to enhance Kentucky data and to collaboratively develop informatics tools and data standards serving the greater cancer research community. In addition, CRI faculty and staff serve as national informatics leaders in cancer data exchange standards and innovative software applications adopted across the United States. CRI is led by Dr. Eric B. Durbin (CP) and is tightly integrated with the Biostatistics and Bioinformatics; Biospecimen Procurement and Translational Pathology; and Oncogenomics SRFs through the provision of essential informatics services that enhance the other MCC SRF service offerings.

项目摘要/摘要癌症研究信息学共享资源设施（CRI SRF）是Markey癌症中心（MCC）管理并应用信息学方法和技术的资源来实现通过策展和开放调查员从广泛的范围内访问高质量数据的科学进步各种机构来源。 CRI扩大了MCC的数据生态系统，以涵盖MCC的整个流域肯塔基州通过联系和与高质量基于人群的数据的整合监视流行病学和最终结果（SEER）肯塔基州癌症注册表。增强和扩展通过CCSG支持和实施上次CCSG评论中建议的更改，CRI具有在提供癌症中心的全面信息服务方面非常具有创新性调查人员。服务大致分为：1）以患者为中心提供综合数据癌症研究数据仓库； 2）对MCC分子肿瘤板的临床决策支持研究； 3）高性能计算（HPC）和生物信息学分析和机器的大数据存储支持自然语言处理的学习方法（NLP）； 4）数据管理以确保完成并准确的临床试验和生物测量数据； 5）自动筛查合格患者进行临床试验招聘; 6）鉴定和注释人类生物测量； 7）软件和数据库开发用于研究和数据传播； 8）为研究计划和授予准备的信息学支持；和9）指导，培训和教育。 CRI服务已被103名MCC成员使用，其中55位（53％）是经同行评审的资助成员。 CRI基础架构和数据管理应用程序可提高高效研究计划与其他SRF之间的互动，例如基础科学研究人员的门户网站访问生物信息学分析结果。 CRI在数据库，数据仓库，NLP，深度表型，HPC，移动设备应用程序，数据共享和数据传播。 CRI密切协调在机构信息资源中的收购和提供与肯塔基大学（英国）生物医学信息学研究所合作，英国临床和转化科学，英国医疗保健信息技术和英国计算科学。 CRI已建立了具有卓越信息学中心的战略联盟和国家机构增强肯塔基州数据并协作开发信息学工具和数据为更大的癌症研究界服务的标准。此外，CRI教师和教职员工担任国家癌症数据交换标准和创新软件应用程序的信息领导者美国。 CRI由Eric B. Durbin博士（CP）领导，并与生物统计学和生物信息学；生物环体采购和转化病理学；和致癌基因学SRF通过提供基本的信息学服务，以增强其他MCC SRF服务产品。