Predoctoral Training in the Genetics of Development, Disease and Regeneration

发育、疾病和再生遗传学博士前培训

• 批准号: 10204624
• 负责人: Bruce H Appel
• 金额: $ 22.12万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10204624
• 关键词: Development; Disease; Genetic; Natural regeneration; Training; pre-doctoral

PROJECT SUMMARY / ABSTRACT The advent of genome editing and induced pluripotent stem cell technologies now provide hope for creating therapies to treat and cure many developmental diseases. However, incomplete knowledge of the genetic regulatory mechanisms that guide cell differentiation and function stands as a significant barrier to progress. Overcoming this barrier will require a workforce with a training foundation that integrates a strong base in genetics, a deep knowledge of developmental, cellular and molecular mechanisms, and the ability to apply basic concepts to the translational potential of stem cell biology. The Genetics of Development, Disease, and Regeneration Training Program seeks to foster a broad foundation of interdisciplinary knowledge and career development that empowers a diverse population of students to apply their training to the study and treatment of developmental diseases. To achieve this goal, the GDDR Program is grounded in five training fundamentals: 1) knowledge base, 2) research skills and innovative technology, 3) hypothesis-driven research, 4) communication skills and 5) professional and career development. The GDDR Program will create a unique training environment by combining the broad and interdisciplinary research interests of our faculty with a training plan that integrates genetic principles and mechanisms into the study of development and stem cell biology. Thirty well-funded and accomplished Training Faculty drawn from 10 basic science and clinical departments create a highly collaborative and interdisciplinary environment. The breadth of our training environment will provide trainees with a diverse menu of labs for thesis training, while maintaining a supportive community and facilitating beneficial interactions between the GDDR Program and other T32-funded programs at the University of Colorado Anschutz Medical Campus. We will take full advantage of these interactions to develop courses and training activities that involve multiple programs. Thus we will broaden the exposure of our trainees to different knowledge, technologies, and career opportunities, and extend the impact of our training program to benefit a larger population of students and researchers at CU AMC. Based on the quality and size of our student pool and Training Faculty, we propose to support six trainees per year, which will permit us to be highly selective while building an interactive group of trainees. Our trainee recruitment plans are structured to attract highly talented students from diverse backgrounds, thereby contributing to a rich setting for training and accomplishment.

项目摘要 /摘要 基因组编辑和诱导多能干细胞技术的出现现在为创建提供了希望 治疗和治疗许多发育疾病的疗法。但是，对遗传的知识不完整 指导细胞分化和功能的调节机制是进步的重要障碍。 克服这个障碍将需要一个劳动力，并在培训基金会上融入了强大的基础 遗传学，对发育，细胞和分子机制的深刻了解以及应用的能力 干细胞生物学的转化潜力的基本概念。发展，疾病和 再生培训计划旨在促进跨学科知识和职业的广泛基础 赋予各种学生人群的发展，将他们的培训应用于研究和治疗 发育疾病。为了实现这一目标，GDDR计划基于五个培训基础知识： 1）知识库，2）研究技能和创新技术，3）假设驱动的研究，4） 沟通技巧和5）专业和职业发展。 GDDR程序将创建一个唯一的 通过将我们教职员工的广泛和跨学科研究兴趣与 将遗传原理和机制集成到发育和干细胞研究中的培训计划 生物学。来自10个基础科学和临床的30个资金资助良好且有才华的培训教师 部门创造了高度协作和跨学科的环境。我们培训的广度 环境将为受训者提供各种实验室供论文培训的菜单，同时保持支持性 社区并促进GDDR计划与其他T32资助计划之间的有益互动 在科罗拉多大学安索斯大学医学校园里。我们将充分利用这些互动 开发涉及多个计划的课程和培训活动。因此，我们将扩大暴露 我们的受训者拥有不同的知识，技术和职业机会，并扩展了我们的影响 培训计划使CU AMC的更多学生和研究人员受益。基于质量 我们的学生游泳池和培训教师的规模，我们建议每年支持六名学员，这将 在建立互动式学员时，请允许我们变得高度选择性。我们的实习生招聘计划 结构化吸引来自不同背景的高度才华的学生，从而为富人做出了贡献 设置培训和成就。