High-performance compact 3T MRI: Technical optimization for advanced brain imaging

高性能紧凑型 3T MRI：高级脑成像的技术优化

• 批准号: 10200806
• 负责人: MATTHEW A. BERNSTEIN
• 金额: $ 99.06万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-18 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10200806
• 关键词: 3-Dimensional; Acceleration; Air; Alzheimer' s Disease; Alzheimer' s disease patient; Anterior; Base of the Brain; Biological Markers; Brain; Brain Diseases; Brain imaging; Brain region; Clinic; Clinical; Cognitive; Development; Diffuse; Diffusion Magnetic Resonance Imaging; Disease; Disease Management; Disease Progression; Echo-Planar Imaging; Emotions; Excision; Financial compensation; Frequencies; Functional Magnetic Resonance Imaging; Functional disorder; Head; Helium; Hippocampus (Brain); Image; Interdisciplinary Study; Limb structure; Liquid substance; Magnetic Resonance Imaging; Measurement; Medial; Memory; Methods; Modeling; Monitor; Morphologic artifacts; Motion; Neurodegenerative Disorders; Neurologic; Neurosciences; Operative Surgical Procedures; Outcome; Patients; Pattern; Performance; Peripheral Nerve Stimulation; Phase; Physiologic pulse; Predisposition; RF coil; Real-Time Systems; Research; Resolution; Scanning; Sinus; Site; Slice; Source; Structure; System; Techniques; Technology; Temporal Lobe; Testing; Time; Tissues; Traumatic Brain Injury; Validation; Visualization; Work; absorption; anatomic imaging; base; cognitive function; cohort; design; elastography; image reconstruction; improved; light weight; mild cognitive impairment; model development; motion sensitivity; neuroimaging; neuropsychiatric disorder; novel; practical application; programs; reconstruction; spatiotemporal; tool; treatment planning; tumor; viscoelasticity

PROJECT SUMMARY/ABSTRACT A breakthrough lightweight, compact 3T MR scanner has been demonstrated to have gradient performance of 700 T/m/s slew rate, operating at 80 mT/m amplitude), which is a slew rate that is 3.5x faster than whole-body MRIs. The proposed next phase of the program will deliver key neuroimaging tools through a multi-disciplinary collaboration between Mayo Clinic and GE Global Research. This proposed work includes further technical development in image reconstruction, systems artifact correction, and pulse sequence programming that exploits the unique, high-performance capabilities of the compact 3T. The Specific Aims of the project are to: · Aim 1) Develop Core Technologies for Echo Planar Imaging (EPI) on the Compact 3T · Aim 2) Develop New MRI-based Connectomics · Aim 3) Develop High-Resolution MR Elastography (MRE) Brain Stiffness Measurement Aim 1 focuses on improving EPI on the compact 3T system to maximally capitalize on its unique gradient slew rate and specific absorption rate (SAR) advantages. Specific tasks related to this aim include: the development of model-based reconstructions, real-time system compensation to eliminate concomitant field artifacts, pulse sequence development for segmented EPI for very fast anatomical imaging, and improved efficiency for simultaneous multislice (SMS) by exploiting the SAR advantages. Aim 2 exploits the compact 3T's dramatically reduced susceptibility artifacts in the region of the medial temporal lobe to enable task-free fMRI spontaneous coactiviation studies of the entire brain, including the hippocampus, which is central to the study of Alzheimer's disease (AD). Aim 3 describes how the compact 3T's high-performance gradients enable, for the first time, 3D gradient echo-based MR elastography (3DMRE). This will enable an 8x reduction in the acquired voxel size compared with the 2DMRE currently acquired with our whole-body MRIs. This has important applications, not-only to pre-surgical planning for tumor resection, but also to potentially develop new biomarkers for the study of neurodenegerative disease, such as AD. The new 3DMRE technique will be studied in the same patient cohort as Aim 2. We believe vastly improved spatial resolution and scan efficiency on the compact 3T MR platform will enable new clinical and neuroscience applications for assessing brain disease management, including traumatic brain injury, tumor treatment planning, and neurodegenerative diseases.

项目摘要/摘要 突破性轻巧，紧凑的3T MR Scanner已被证明具有梯度性能 700 t/m/s的振荡速率，以80 mt/m的振幅运行） MRI。 合作梅奥诊所和GE全球研究。 紧凑型3T的独特，高性能的能力。 该项目的具体目的是： ·目标1）在紧凑型3T上开发用于回声平面成像（EPI）的核心技术 ·目标2）开发新的基于MRI的连接组学 ·目标3）开发高分辨率MR弹性图（MRE）脑刚度测量 AIM 1专注于改进紧凑型3T系统的EPI，以最大程度地利用其独特的梯度 驱动率和特定的吸收率（SAR）优势，实时系统补偿以消除伴随的现场伪像 分段EPI的脉冲序列开发非常出现的延伸成像，并提高了SAR优势的同步粘液（SMS）的效率。 AIM 2利用了紧凑型3T对轮胎脑的内侧颞叶浮动研究的敏感性急剧降低，包括海马，这对于研究阿尔茨海默氏病（AD）的研究至关重要。 AIM 3描述了紧凑型3T高性能梯度如何首次启用3D梯度 基于回声的MR弹性图（3DMRE）。 使用我们的体型MRIS获得的2DMRE。 肿瘤切除的手术前计划W 3DMRE技术将在同一患者队列中与AIM进行研究 2。我们认为，紧凑型3T MR平台上的空间分辨率和扫描效率将大大提高 新的临床和神经科学应用用于评估脑部疾病管理，包括脑部脑部脑部疾病 损伤，肿瘤治疗计划和神经退行性疾病。

项目成果

Reducing PNS with minimal performance penalties via simple pulse sequence modifications on a high-performance compact 3T scanner.

• DOI: 10.1088/1361-6560/ab99e2
• 发表时间: 2020-07-31
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: In MH;Shu Y;Trzasko JD;Yarach U;Kang D;Gray EM;Huston J;Bernstein MA
• 通讯作者: Bernstein MA

Improved Brain MR Imaging from a Compact, Lightweight 3T Scanner with High-Performance Gradients.

• DOI: 10.1002/jmri.27812
• 发表时间: 2022-01
• 期刊: Journal of magnetic resonance imaging : JMRI
• 作者: Camerucci E;Campeau NG;Trzasko JD;Gray EM;Bernstein MA;Cogswell PM;Shu Y;Foo TK;Huston J 3rd
• 通讯作者: Huston J 3rd

Average SAR prediction, validation, and evaluation for a compact MR scanner head-sized RF coil.

• DOI: 10.1016/j.mri.2021.10.011
• 发表时间: 2022-01
• 期刊: Magnetic resonance imaging
• 影响因子: 2.5
• 作者: Tarasek MR;Shu Y;Kang D;Tao S;Gray E;Huston J 3rd;Hua Y;Yeo DTB;Bernstein MA;Foo TK
• 通讯作者: Foo TK

Lightweight, compact, and high-performance 3T MR system for imaging the brain and extremities.

• DOI: 10.1002/mrm.27175
• 发表时间: 2018-11
• 期刊: Magnetic resonance in medicine
• 影响因子: 3.3
• 作者: Foo TKF;Laskaris E;Vermilyea M;Xu M;Thompson P;Conte G;Van Epps C;Immer C;Lee SK;Tan ET;Graziani D;Mathieu JB;Hardy CJ;Schenck JF;Fiveland E;Stautner W;Ricci J;Piel J;Park K;Hua Y;Bai Y;Kagan A;Stanley D;Weavers PT;Gray E;Shu Y;Frick MA;Campeau NG;Trzasko J;Huston J 3rd;Bernstein MA
• 通讯作者: Bernstein MA

Application of Adaptive Image Receive Coil Technology for Whole-Brain Imaging.

• DOI: 10.2214/ajr.20.22812
• 发表时间: 2021-03
• 期刊: AJR. American journal of roentgenology
• 作者: Cogswell PM;Trzasko JD;Gray EM;Campeau NG;Rossman PJ;Kang D;Robb F;Stormont RS;Lindsay SA;Bernstein MA;McGee KP;Huston J 3rd
• 通讯作者: Huston J 3rd