Research Experience & Training Core

研究经历

• 批准号: 10361893
• 负责人: CHRISTIAN TSCHUDI
• 金额: $ 10.01万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-07 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10361893
• 关键词: Address; Area; Biological; Biomedical Research; Biosensor; Chemicals; Chemistry; Communication; Communication Research; Communities; Community Outreach; Competence; Connecticut; Data Analyses; Data Analytics; Development; Dioxanes; Discipline; Early identification; Educational process of instructing; Educational workshop; Engineering; Ensure; Environmental Engineering technology; Environmental Health; Environmental Protection; Evaluation; Exposure to; Faculty; Fostering; Foundations; Genetic; Goals; Government Agencies; Health; Hepatocarcinogenesis; Industry; Information Dissemination; Infrastructure; Interdisciplinary Study; Joints; Knowledge; Malignant neoplasm of liver; Medicine; Mentors; Mentorship; Monitor; Play; Population; Postdoctoral Fellow; Privatization; Process; Program Research Project Grants; Public Health; Public Health Schools; Research; Research Activity; Research Personnel; Research Training; Risk; Role; Scientist; Students; Superfund; Technology; Toxicology; Training; Training Programs; Translational Research; Universities; University resources; Update; Water Pollutants; Water Supply; base; cancer biomarkers; community engagement; data management; design; doctoral student; drinking water; education research; environmental chemical; environmental chemistry; experience; exposed human population; improved; liver injury; medical schools; metabolomics; next generation; novel; oxidation; potential biomarker; pre-doctoral; programs; recruit; remediation; reproductive; sensor; skills; symposium; synergism

ABSTRACT The Yale Superfund Research and Training Program (YSRTP) will foster problem-based, solution-oriented research related to the theme of water contaminant fate, exposure, remediation, and adverse health effects. To be most effective, this endeavor requires cross-trained scientists, engineers, and biomedical researchers with wide-ranging communication skills to successfully address emerging research and health questions. The proposed YSRTP unites the fields of public health, medicine, genetics, environmental chemistry, environmental engineering, and chemical fate and transport. We will leverage this disciplinary diversity, departmental and University resources, and YSRTP’s diverse research areas and cores to produce trainees with depth in their specialized field, and a breadth of knowledge and professional experiences in environmental health, chemistry, and engineering; disciplines that are important for controlling exposure to hazardous environmental chemicals. The goal of the YSRTP Research Experience Training Coordination Core (RETCC) is to expand the breadth of educational, research, and professional development opportunities to pre- and post-doctoral trainees. Four specific aims are proposed. 1. Recruit a cadre of diverse, academically prepared doctoral students and post- doctoral researchers; 2. Provide interdisciplinary training through a requirement of cross-disciplinary coursework and focused training in community outreach, results dissemination, risk communication, and research translation; 3. Design and implement a program for interdisciplinary research exchanges within and external to Yale; and 4. Encourage trainee professional development through planned interactions with community partners, government agencies, and private industry. RETCC central activities will include specific symposia and workshops to broaden trainee education and research skillsets, mentorship programs to prepare students for candidacy exams and monitor dissertation progress; a graduate research seminar and other ancillary activities to encourage interaction among trainees and build a scholastic community, and an evaluation process to continually update and improve the RETCC. Training will leverage the broader Yale University teaching, research, and mentoring infrastructure and build synergies with the YSRTP cores in administration (research translation), community engagement and data management and analytics. This training core will focus on pre- and post-doctoral trainees working in the fields of chemistry, environmental engineering, public health, and biomedical research within the YSRTP and includes an interdisciplinary (environmental engineering and biomedical research) directorship. Specific research areas include: the effects of water contaminants on reproductive toxicology, evaluation of 1,4-Dioxane (1.4-DX) exposure and early biological effects in drinking water, identification of early vs. late 1,4-DX-induced liver damage and carcinogenesis and of potential biomarkers of exposure, biosensors and chemical sensors and online contaminant monitoring, development of next-generation, modular advanced oxidation process technology.

抽象的 耶鲁大学超级基金研究和培训计划（YSRTP）将促进以问题为基础、以解决方案为导向 与水污染物命运、暴露、修复和不利健康影响主题相关的研究。 为了最有效，这项工作需要经过交叉培训的科学家、工程师和生物医学研究人员 广泛的沟通技巧，以成功解决新出现的研究和健康问题。 拟议的 YSRTP 单位包括公共卫生、医学、遗传学、环境化学、环境 我们将利用这种学科多样性、部门和运输。 大学资源以及 YSRTP 的多元化研究领域和核心，可培养具有深度知识的学员 专业领域，以及在环境健康、化学、 和工程；对于控制危险环境化学品的暴露很重要的学科。 YSRTP 研究经验培训协调核心 (RETCC) 的目标是扩大研究经验培训的广度 为博士前和博士后学员提供教育、研究和专业发展机会 四。 提出了具体目标 1. 招募一支多元化的、学术上有准备的博士生和博士后骨干队伍。 2、通过跨学科的要求，提供跨学科的培养； 社区外展、成果传播、风险沟通等方面的课程作业和重点培训 研究翻译； 3. 设计和实施跨学科研究交流计划； 耶鲁大学外部；以及 4. 通过有计划的互动来鼓励学员的专业发展。 社区合作伙伴、政府机构和私营企业将包括具体的活动。 研讨会和讲习班，以扩大受训者教育和研究技能，指导计划，以准备 学生参加候选考试并监控论文进度；研究生研究研讨会等 鼓励学员之间互动并建立学术社区的辅助活动，以及 持续更新和改进 RETCC 培训的评估流程将利用更广泛的耶鲁大学。 大学教学、研究和指导基础设施，并与 YSRTP 核心建立协同效应 管理（研究翻译）、社区参与以及数据管理和分析。 该培训核心将重点关注化学、环境领域的博士前和博士后学员 YSRTP 内的工程、公共卫生和生物医学研究，包括跨学科研究 （环境工程和生物医学研究）主任职位具体研究领域包括：影响。 水污染物对生殖毒理学的影响、1,4-二恶烷 (1.4-DX) 暴露和早期评估 饮用水中的生物效应，早期与晚期 1,4-DX 引起的肝损伤的鉴定以及 致癌作用和潜在的暴露生物标志物、生物传感器和化学传感器以及在线 污染物监测，开发下一代模块化高级氧化工艺技术。