Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age

排气后的后遗症：学龄前早产儿新生儿间歇性低氧血症后果的个性化预后模型

• 批准号: 10363406
• 负责人: Namasivayam Ambalavanan
• 金额: $ 148.56万
• 依托单位: LURIE CHILDREN'S HOSPITAL OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-15 至 2026-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10363406
• 关键词: Age; Age-Months; Asthma; Breathing; Bronchopulmonary Dysplasia; Caffeine; Characteristics; Child; Child Care; Childhood; Clinical; Clinical Data; Clinical Treatment; Cognitive; Collaborations; Consent; Data; Development; Diagnosis; Discipline of Nursing; Disease; Early Diagnosis; Early Intervention; Early identification; Emotional; Enrollment; Event; Frequencies; Funding; Future; Goals; Health; Hypoxemia; Impairment; Infant; Infrastructure; Intervention; Intervention Trial; Investigation; Knowledge; Life; Link; Measures; Motor; National Heart, Lung, and Blood Institute; Neonatal; Neonatal Intensive Care; Neonatal Intensive Care Units; Nervous System Physiology; Neurodevelopmental Impairment; Nursery Schools; Outcome; Oxygen; Pathologic; Pathway interactions; Patients; Pattern; Persons; Pharmaceutical Preparations; Physiological; Play; Population; Pregnancy; Premature Birth; Premature Infant; Prevalence; Prevention strategy; Preventive; Prognosis; Prospective Studies; Protocols documentation; Records; Research; Research Personnel; Resolution; Resources; Respiratory physiology; Risk; Role; Sensory; Sleep; Sleep Apnea Syndromes; Structure; Therapeutic; Time; Training; United States National Institutes of Health; Vent; Weaning; Work; advanced analytics; airway hyperresponsiveness; asthma model; base; clinical care; clinical phenotype; cohort; cost; early screening; empowered; experience; improved; infancy; innovation; negative affect; neonatal care; novel therapeutics; peer; postnatal; premature; prognostic; prognostic model; programs; rehabilitation service; respiratory; response; standard of care; supplemental oxygen; targeted treatment

Project Summary / Abstract This is the application from collaborators of the Prematurity-Related Ventilatory Control (Pre-Vent): Role in Respiratory Outcomes NHLBI Collaborative Program. Central to this proposal is a prospective study entitled “Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-school Age”. This multicenter proposal innovatively combines detailed clinical phenotyping with advanced analytics of longitudinal recordings of intermittent hypoxemia (IH) events to develop personalized prognostic models of long-term outcomes that could transform clinical care by allowing for timely identification of at-risk infants and specific pathologic IH patterns for future trials of targeted intervention. Extremely premature birth and various postnatal factors can negatively affect outcome. In a significant proportion of extremely premature infants the sequelae persist beyond infancy with relatively high rates of asthma and sleep disordered breathing (SDB) in childhood and worrisome prevalence of neurodevelopmental impairment (NDI). This multicenter proposal will systematically and innovatively examine the interaction between IH during neonatal intensive care and these sequelae by means of detailed clinical phenotyping and advanced analytics. The proposed investigation will provide personalized prognosis and identification of infants at risk of poor long-term outcome that could transform clinical care and uncover targets for preventive or therapeutic strategies. The main goal of this proposal is to build prognostic models of asthma, SDB, and NDI at pre-school age in former extremely premature infants based on physiologic waveforms and clinical characteristics in the neonatal intensive care unit. To achieve this goal this time-sensitive proposal leverages the population, research structure and expertise, and analytic resources developed for the NHLBI-funded Pre-Vent collaboration.

项目概要/摘要 这是早产相关通气控制（Pre-Vent）合作者的应用程序：作用 呼吸结果 NHLBI 合作计划的核心是一项题为“前瞻性研究”的研究。 “排气后的后遗症：新生儿间歇性发作后果的个性化预后模型 “学龄前早产儿的低氧血症”这项多中心提案创新性地结合了详细的内容。 通过对间歇性低氧血症 (IH) 事件的纵向记录进行高级分析来进行临床表型分析 开发长期结果的个性化预后模型，可以通过允许改变临床护理 及时识别高危婴儿和特定的病理性 IH 模式，以便将来进行有针对性的干预试验。 极度早产和各种产后因素会对结果产生很大比例的负面影响。 极早产儿的后遗症持续到婴儿期之后，哮喘和睡眠的发生率相对较高 儿童期呼吸障碍（SDB）和令人担忧的神经发育障碍（NDI）患病率。 这项多中心提案将系统地、创新地研究新生儿期 IH 之间的相互作用。 通过详细的临床表型分析和先进的分析来进行重症监护和这些后遗症。 拟议的调查将提供个性化预后并识别存在长期不良风险的婴儿 结果可以改变临床护理并发现预防或治疗策略的目标。 该提案的主要目标是在以前的学龄前儿童中建立哮喘、SDB 和 NDI 的预后模型 基于新生儿生理波形和临床特征的极早产儿 为了实现这一目标，这一时间敏感的提案利用了人口、研究结构。 为 NHLBI 资助的 Pre-Vent 合作开发的专业知识和分析资源。