Clinical and host microbiome features in the development of acute otitis media
急性中耳炎发生过程中的临床和宿主微生物组特征
基本信息
- 批准号:10735848
- 负责人:
- 金额:$ 12.74万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-07-10 至 2028-06-30
- 项目状态:未结题
- 来源:
- 关键词:AcuteAdolescentAgeAge MonthsAntibioticsAsthmaAwardBiochemistryBiologicalBirthCOVID-19CharacteristicsChildChild health careChildhoodClinicalClinical DataClinical ResearchCohort StudiesCommunicable DiseasesCorynebacteriumDataData MartData SetDevelopmentDiseaseElectronic Health RecordEnrollmentEpidemiologistEvaluationExposure toFunctional disorderFundingGoalsGrowthHealthHealth Care VisitHomeHuman MicrobiomeImmune responseInfantInfectionInfectious AgentInflammatory ResponseIntegration Host FactorsInterdisciplinary StudyK-Series Research Career ProgramsLeadLifeLinkMediatingMentorsMentorshipMethodologyMethodsMolecular BiologyMothersNoseOtitis MediaOtolaryngologyPathogenesisPatternPediatric ResearchPhysiciansPopulationPositioning AttributePredispositionPreventionProspective cohortPublic Health InformaticsRecording of previous eventsRecurrenceResearchResearch ActivityResearch DesignResearch PersonnelRespiratory Tract InfectionsRiskRoleSamplingScientistSerotypingSpecimenStatistical Data InterpretationStatistical ModelsStreptococcus pneumoniaeTestingTimeTrainingTraining ActivityUnited States National Institutes of HealthUpper Respiratory InfectionsUpper respiratory tractVaccinationWheezingWorkantimicrobialatopybacteriomecareercareer developmentchronic respiratory diseasecohortdata resourcedysbiosisear infectionear microbiomeeducational atmosphereexperiencegut microbiomehealth care service utilizationhost microbiomeimprovedintrapartumlarge datasetsmetagenomic sequencingmicrobialmicrobial communitymicrobiomemicrobiome alterationmiddle earmiddle ear fluidmultidisciplinarynasal swabobservational cohort studypathogenpathogenic bacteriapopulation healthpreventprogramsrecurrent infectionresearch studyrespiratoryrespiratory healthrespiratory microbiomesextherapeutic targetvirome
项目摘要
ABSTRACT
This Mentored Career Development (K01) Award proposal will provide an outstanding educational environment,
mentoring, and training for Dr. Jillian Hurst, a pediatric infectious diseases researcher whose overarching career
goal is to integrate clinical and biological data to further our understanding of the role of the microbiome and
related host factors in modifying susceptibility to common childhood infections Dr. Hurst originally trained in
biochemistry and molecular biology and has worked in translational pediatric research for the past five years.
This career development award will allow her to receive training in omics and advanced statistical analyses using
large datasets, permitting her to lead multidisciplinary teams that use large clinical and omics datasets to
evaluate factors underlying common pediatric infections. The proposed research studies center on the role of
the upper respiratory microbiome in the development and recurrence of acute otitis media (AOM; middle ear
infection), the most common infectious disease of childhood. Dr. Hurst will test the hypothesis that early life
antibiotic exposures disrupt the development of the URT microbiome, predisposing children to AOM and other
common respiratory infections. She will use over eight years of electronic health records data, banked
longitudinal upper respiratory specimens collected from children from birth to age 2, and samples and data from
a prospective cohort of children with recurrent AOM to accomplish the following specific aims: 1) Assess the
impact of early life antibiotic exposures on recurrent AOM development.; 2) Delineate the effects of early life
antibiotic exposures on URT microbiome development; and 3) Evaluate associations between antibiotic
exposures and the URT microbiome in children with recurrent AOM. Findings from these studies will guide the
development of new strategies to prevent and treat AOM and associated infections, including guidance for
antibiotic use and identification of therapeutic targets within the URT microbiome that could be leveraged to
restore URT microbiome function and improve respiratory health among young children. Mentorship will be
provided by a group of three established investigators with complementary expertise: Dr. Christopher Woods,
an infectious diseases physician and clinical epidemiologist with expertise in the evaluation of host responses to
infectious agents; Dr. Matthew Kelly, a pediatric infectious diseases physician with expertise in the human
microbiome and clinical omics analyses; and Dr. Benjamin Goldstein, a biostatistician with expertise in the use
of electronic health records data for population health analyses. Additionally, Dr. Hurst will be advised by internal
and external advisors with expertise in antimicrobial stewardship, pediatric otolaryngology, health informatics
and omics analyses, and the treatment and pathophysiology of AOM. Completion of the proposed training and
research activities will establish Dr. Hurst as an independent investigator who will lead an NIH-funded research
program investigating host factors and exposures underlying common infections in children.
抽象的
这项指导的职业发展(K01)奖项建议将提供一个杰出的教育环境,
指导和培训吉利安·赫斯特(Jillian Hurst)
目标是整合临床和生物学数据,以进一步了解微生物组和
相关的宿主因素改变了最初接受过培训的赫斯特医生的普通儿童感染的敏感性
在过去的五年中,生物化学和分子生物学并从事转化小儿研究。
该职业发展奖将使她能够使用OMIC和高级统计分析的培训
大型数据集,允许她领导使用大型临床和OMIC数据集的多学科团队
评估普通小儿感染的基本因素。拟议的研究中心关于
急性中耳炎发育和复发的上呼吸道微生物组(AOM;中耳
感染),最常见的儿童传染病。赫斯特博士将检验早期生活的假设
抗生素暴露破坏了URT微生物组的发展,使儿童易于使用AOM和其他
常见的呼吸道感染。她将使用八年的电子健康记录数据,并将
从出生到2岁的儿童收集的纵向上呼吸标本,以及来自
反复AOM的前瞻性队列以实现以下特定目的:1)评估
早期生命抗生素暴露对复发AOM开发的影响。 2)描述早期生命的影响
关于URT微生物组发育的抗生素暴露; 3)评估抗生素之间的关联
复发性AOM儿童的暴露和URT微生物组。这些研究的发现将指导
制定预防和治疗AOM和相关感染的新策略,包括指导
在URT微生物组中使用抗生素的使用和鉴定可以利用
恢复urt微生物组功能并改善幼儿的呼吸健康。指导将是
由三名成熟的调查员组成的小组具有互补的专业知识:克里斯托弗·伍兹博士,
传染病医师和临床流行病学家在评估宿主反应方面具有专业知识
传染性药物;马修·凯利(Matthew Kelly)博士,一名儿科传染病医师,在人类方面具有专业知识
微生物组和临床法分析;和本杰明·戈德斯坦(Benjamin Goldstein)博士,一位具有专业知识的生物统计学家
人口健康分析的电子健康记录数据。此外,赫斯特博士将由内部建议
以及具有抗菌管理,小儿耳鼻喉科,健康信息学专业知识的外部顾问
OMICS分析以及AOM的治疗和病理生理学。完成拟议的培训和
研究活动将建立赫斯特博士为独立研究者,将领导NIH资助的研究
计划调查儿童常见感染的宿主因素和暴露。
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Leveraging the human microbiota to target bacterial respiratory pathogens: new paths toward an expanded antimicrobial armamentarium.
- DOI:10.1128/mbio.00854-23
- 发表时间:2023-08-31
- 期刊:
- 影响因子:6.4
- 作者:
- 通讯作者:
Dolosigranulum pigrum: A promising nasal probiotic candidate.
- DOI:10.1371/journal.ppat.1011955
- 发表时间:2024-02
- 期刊:
- 影响因子:6.7
- 作者:
- 通讯作者:
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Jillian Heyward Hurst其他文献
Jillian Heyward Hurst的其他文献
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{{ truncateString('Jillian Heyward Hurst', 18)}}的其他基金
Coordinated regulation of MAP kinase signaling by ubiquitination
通过泛素化协调调节 MAP 激酶信号传导
- 批准号:
8223685 - 财政年份:2011
- 资助金额:
$ 12.74万 - 项目类别:
Coordinated regulation of MAP kinase signaling by ubiquitination
通过泛素化协调调节 MAP 激酶信号传导
- 批准号:
8060988 - 财政年份:2011
- 资助金额:
$ 12.74万 - 项目类别:
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