Theory and Modeling of the Orofacial Active Sensation

口面部主动感觉的理论和建模

基本信息

批准号：
10199077
负责人：
David Golomb
金额：
$ 22.76万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-15 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10199077
关键词：
Address Affect Air Anatomy Behavior Behavioral Biological Brain Stem Cell Nucleus Code Complex Computational Technique Computer Models Data Elements Engineering Esthesia Exploratory Behavior Feedback Fire - disasters Future Ganglia Generations Goals Head Movements Lead Measures Mechanics Mechanoreceptors Modeling Motor Motor Activity Motor Neurons Movement Muscle Nature Neurologic Neuromechanics Neurons Nose Pattern Perception Periodicity Physiological Plant Model Plants Positioning Attribute Property Psychological Techniques Pump Research Project Grants Scheme Sensory Sensory Ganglia Signal Transduction Structure of trigeminal ganglion Synapses System Testing Time Torque Touch sensation Vibrissae Work active control base chemical property computer framework design electrical property experimental study improved mechanical properties motor control neuroregulation operation orofacial predictive modeling response sensory input theories vocalization

项目摘要

Project 4. Abstract Theory and modeling of the orofacial active sensation (Golomb as lead; Freund; Kleinfeld) This Research Project addresses the dynamics of the sensorimotor brainstem circuits for active sensing. Our initial focus is on the vibrissae system, given the relative plethora of information on this aspect of orofacial behavior. The specific elements in our model include the vibrissae, the vibrissa motor plant, and sensory and motor neuronal ganglia and nuclei. We will use theoretical and computational techniques to describe the activity of several "Components" and, of great generality to perception, how active feedback alters the nature of the sensory input as a consequence ofs active sensing. First we will analyze the interaction of the vibrissae and the motor plant, specifically how contact effects the motor plant and the forces and torques on the vibrissae. We then quantify the transformation of mechanical signals in whisker follicle to neuronal spiking of trigeminal ganglion neurons during vibrissa movement and touch with object. At the motor brainstem level, we explore the generation and synchronization of firing patterns of motoneurons and pre-motoneurons, and their reset by the pre-Bötzinger complex. Finally, we will construct models of larger brainstem loops and explore general issues of how sensory signals control motor activity during behavior. Our models will be constrained by connectivity data from Research Project 1 and physiological data about the activation and operation of orofacial exploratory circuitry from Research Project 2 and 3, and their predictions will be tested in Research Project 2 and 3.

项目4。摘要口面活性感觉的理论和建模（Golomb作为铅； Freund； Kleinfeld）该研究项目解决了感官脑干电路的动力学，以实现主动灵敏度。鉴于关于Orofacial的这一方面的相对大量信息，我们的最初重点是颤音系统行为。我们模型中的特定元素包括颤音，颤音厂运动厂以及感觉和运动神经神经节和核。我们将使用理论和计算技术来描述几种“组成部分”的活动，并且具有很大的感知性，主动反馈如何改变性质感官输入的结果是主动灵敏度。首先，我们将分析颤音和运动厂的相互作用，特别是接触如何影响汽车厂以及颤音上的力和扭矩。然后，我们量化机械的转换在颤音中的神经神经节神经元的神经元尖峰中的晶须叶中的信号和触摸对象。在运动脑干级别，我们探索发射的产生和同步运动神经元和前膜神经元的模式，并由前胞胞饼复合体重置。最后，我们会的较大的脑干循环的构建模型，并探讨感官信号如何控制电动机的一般问题行为期间的活动。我们的模型将受到研究项目1的连接数据以及有关的物理数据的约束研究项目2和3的口面探索电路的激活和操作及其预测将在研究项目2和3中进行测试。