Theory and Modeling of the Orofacial Active Sensation

口面部主动感觉的理论和建模

基本信息

批准号：
10199077
负责人：
David Golomb
金额：
$ 22.76万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-15 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10199077
关键词：
Address Affect Air Anatomy Behavior Behavioral Biological Brain Stem Cell Nucleus Code Complex Computational Technique Computer Models Data Elements Engineering Esthesia Exploratory Behavior Feedback Fire - disasters Future Ganglia Generations Goals Head Movements Lead Measures Mechanics Mechanoreceptors Modeling Motor Motor Activity Motor Neurons Movement Muscle Nature Neurologic Neuromechanics Neurons Nose Pattern Perception Periodicity Physiological Plant Model Plants Positioning Attribute Property Psychological Techniques Pump Research Project Grants Scheme Sensory Sensory Ganglia Signal Transduction Structure of trigeminal ganglion Synapses System Testing Time Torque Touch sensation Vibrissae Work active control base chemical property computer framework design electrical property experimental study improved mechanical properties motor control neuroregulation operation orofacial predictive modeling response sensory input theories vocalization

项目摘要

Project 4. Abstract Theory and modeling of the orofacial active sensation (Golomb as lead; Freund; Kleinfeld) This Research Project addresses the dynamics of the sensorimotor brainstem circuits for active sensing. Our initial focus is on the vibrissae system, given the relative plethora of information on this aspect of orofacial behavior. The specific elements in our model include the vibrissae, the vibrissa motor plant, and sensory and motor neuronal ganglia and nuclei. We will use theoretical and computational techniques to describe the activity of several "Components" and, of great generality to perception, how active feedback alters the nature of the sensory input as a consequence ofs active sensing. First we will analyze the interaction of the vibrissae and the motor plant, specifically how contact effects the motor plant and the forces and torques on the vibrissae. We then quantify the transformation of mechanical signals in whisker follicle to neuronal spiking of trigeminal ganglion neurons during vibrissa movement and touch with object. At the motor brainstem level, we explore the generation and synchronization of firing patterns of motoneurons and pre-motoneurons, and their reset by the pre-Bötzinger complex. Finally, we will construct models of larger brainstem loops and explore general issues of how sensory signals control motor activity during behavior. Our models will be constrained by connectivity data from Research Project 1 and physiological data about the activation and operation of orofacial exploratory circuitry from Research Project 2 and 3, and their predictions will be tested in Research Project 2 and 3.

项目 4. 摘要口面部主动感觉的理论和建模（Golomb 为主导；Freund；Kleinfeld）该研究项目致力于主动传感的感觉运动脑干回路的动力学。鉴于口面部这方面的信息相对较多，我们最初的重点是触须系统我们模型中的具体元素包括触须、触须运动装置以及感觉和感觉。我们将使用理论和计算技术来描述运动神经节和神经核。几个“组件”的活动，以及对感知具有极大普遍性的主动反馈如何改变性质作为主动传感的结果的感觉输入。首先，我们将分析触须和运动装置的相互作用，特别是接触如何影响然后我们量化机械的转变。触毛运动过程中须毛囊向三叉神经节神经元发出的信号在运动脑干层面，我们探索放电的产生和同步。运动神经元和前运动神经元的模式，以及它们被前 Bötzinger 复合体重置。构建更大的脑干环路模型并探索感觉信号如何控制运动的一般问题行为期间的活动。我们的模型将受到研究项目 1 的连接数据和生理数据的限制研究项目 2 和 3 的口面部探索回路的激活和操作及其预测将在研究项目 2 和 3 中进行测试。