Representation of Perceived Odor Intensity

感知气味强度的表示

• 批准号: 10200168
• 负责人: Joel D Mainland
• 金额: $ 76.45万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10200168
• 关键词: Animal Model; Animals; Behavior; Behavioral Assay; Biological Models; Brain; Characteristics; Chemical Structure; Code; Fruit; Genotype; Human; Individual; Inhalation; Measures; Modeling; Molecular; Molecular Structure; Mus; Neurons; Neurosciences; Odorant Receptors; Odors; Partner in relationship; Pattern; Perception; Photons; Population; Psychophysics; Receptor Activation; Reporting; Response Latencies; Shapes; Smell Perception; Source; Stimulus; System; Testing; Time; Training; Translating; Variant; Vision; Work; awake; base; experimental study; genetic manipulation; loss of function; neural correlate; neural model; novel; olfactory bulb; olfactory receptor; olfactory sensory neurons; optogenetics; physical property; piriform cortex; predictive modeling; receptor; receptor function; relating to nervous system; response; sound; tool

Project Summary (Project 3: Representation of perceived odor intensity) The odor of French fries contains more than 500 molecules, but can be replicated by combining only 21 of them. The key to understanding which molecules matter and which are irrelevant is odor intensity. When odors are used to convey information, whether it be the ripeness of a fruit, the note of a predator, or the aroma of a potential mate, intensity is required to know how much is present and where to locate the source. Several neural models have been proposed to explain how the brain represents intensity, but most experimental manipulations manipulate intensity indirectly, by changing odor concentration, rather than directly delivering stimuli at a targeted perceived intensity. In this proposal we use human and mouse behavior to measure the perceived intensity of odors, and then use intensity-balanced odors to probe the neural correlates of perception. With access to the perceptual readout in a model system, we can also use genetic manipulations and optogenetic stimulation to probe how receptor activation profiles translate into perceived intensity. By examining both neural and perceptual responses to the same stimuli across both species, these experiments will reveal how intensity is encoded by receptor activation patterns, the bulb, and the cortex and develop models that predict perceived intensity based on either chemical structure or neural activity patterns.

项目摘要（项目3：感知气味强度的表示） 炸薯条的气味含有500多个分子，但只能通过组合21种来复制 他们。了解哪种分子重要以及哪些无关紧要的关键是气味强度。当气味时 用于传达信息，无论是果实的成熟度，捕食者的音符还是A的香气 潜在的伴侣需要强度才能知道存在多少以及在哪里找到来源。一些 已经提出了神经模型来解释大脑如何代表强度，但大多数实验性 通过改变气味浓度，而不是直接交付 在有针对性的感知强度下刺激。在此提案中，我们使用人类和鼠标行为来衡量 感知的气味强度，然后使用强度平衡的气味来探测 洞察力。通过访问模型系统中的感知读数，我们也可以使用遗传操作 和光遗传学刺激，以探测受体激活曲线如何转化为感知的强度。经过 这些实验检查了两个物种的神经和感知反应对同一刺激的反应 将揭示强度如何通过受体激活模式，灯泡和皮层编码并发展 基于化学结构或神经活动模式预测强度的模型。