Perceptual effects of genetic variation in human odorant receptors

人类气味受体遗传变异的感知影响

• 批准号: 8870713
• 负责人: Joel D Mainland
• 金额: $ 0.56万
• 依托单位: MONELL CHEMICAL SENSES CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-12 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8870713
• 关键词: Affect; Afferent Neurons; Agonist; Alleles; Beverages; Biological Assay; Canned Foods; Code; Detection; Development; Environmental Hazards; Epithelium; Food; Gene Cluster; Genes; Genetic Polymorphism; Genetic Variation; Genome; Genotype; Goals; Health; Human; In Vitro; Individual; Lead; Learning; Ligands; Link; Linkage Disequilibrium; Maps; Measurement; Measures; Methods; Modeling; Mutation; Natural Gas; Nature; Odorant Receptors; Odors; Outcome; Pattern; Perception; Phenotype; Play; Pollution; Property; Psychophysics; Quality of life; Receptor Activation; Receptor Gene; Research; Resources; Role; Smell Perception; Smoke; System; Techniques; Testing; Therapeutic Intervention; Variant; base; food flavor; genetic association; genetic variant; human subject; interest; next generation sequencing; novel; olfactory receptor; receptor; receptor function; screening

DESCRIPTION (provided by applicant): The sense of smell is an early warning system for the detection of environmental hazards such as spoiled food, natural gas leaks, smoke, or airborne pollution. Smells also play an important role in quality of life, imparting the flavor of foods and beverages. The long- term objective of this proposal is to understand the nature of odor coding at the receptor level. Currently, little is known about how changes in the receptor activation pattern alter olfactory perception. In the research proposed here, we use next-generation sequencing techniques, heterologous expression systems, and human psychophysics to understand the links between receptor genotype, receptor function and olfactory perception. Learning the rules for transforming receptor activity into perception will advance our understanding of odor coding.

描述（由申请人提供）：嗅觉是一种早期预警系统，用于检测环境危害，例如变质的食物、天然气泄漏、烟雾或空气污染。气味在生活质量中也发挥着重要作用，赋予食物的味道和 饮料。该提案的长期目标是了解受体水平上气味编码的本质。目前，人们对受体激活模式的变化如何改变嗅觉知之甚少。在此提出的研究中，我们使用下一代测序技术、异源表达系统和人类心理物理学来了解受体基因型、受体功能和嗅觉感知之间的联系。学习将受体活动转化为感知的规则将增进我们对气味编码的理解。