SPARED Center

幸免中心

• 批准号: 10356102
• 负责人: William A. Carlezon
• 金额: $ 37.14万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2024-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10356102
• 关键词: Area; Arts; Autopsy; Award; Behavioral Mechanisms; Biological Psychiatry; Boston; Clinical; Clinical Research; Collaborations; Communication; Communities; Complement; Corticotropin-Releasing Hormone; Country; Development; Doctor of Medicine; Doctor of Philosophy; Education; Education and Outreach; Educational process of instructing; Ensure; Facebook; Faculty; Fellowship; Future; Grant; Healthcare; Hospitals; International; Intranet; Leadership; Link; Major Depressive Disorder; Mental disorders; Methods; Mission; Molecular Genetics; National Institute of Mental Health; Neurosciences; Patients; Peptides; Persons; Physiological; Post-Traumatic Stress Disorders; Postdoctoral Fellow; Research; Research Personnel; Research Support; Resources; Science; Scientist; Seeds; Senior Scientist; Site; Societies; Stress; Student recruitment; Students; Teaching Hospitals; Training; Training Activity; Training and Education; Travel; Twitter; Update; Work; brain tissue; career; career development; college; data management; educational atmosphere; graduate student; innovation; medical schools; meetings; member; multidisciplinary; news; organizational structure; outreach; pituitary adenylate cyclase activating polypeptide; pre-clinical; preclinical study; programs; science museum; senior faculty; social media; statistics; symposium; synergism; web site

SUMMARY: ADMINISTRATIVE CORE The Silvio O. Conte Center for Stress Peptide Advanced Research, Education, & Dissemination (SPARED) at McLean Hospital will create an innovative, multidisciplinary, and comprehensive research program combining preclinical and clinical components to elucidate mechanisms by which unregulated stress triggers psychiatric illness. The 5 thematically-linked projects will focus on interactions between CRF (corticotropin-releasing factor) and PACAP (pituitary adenylate cyclase activating polypeptide), peptides implicated in stress responsiveness and development of debilitating illnesses including PTSD. To support this research mission, the Administrative Core will maintain the organizational structure necessary for enabling successful communication, integration, and cooperation among SPARED Center projects, providing a mechanism for frequent updating, and ensuring effective allocation and utilization of resources for maximizing synergy and scientific advancement. The Core will also support the education and training activities needed to develop future researchers at McLean, a national leader as the premier psychiatric teaching hospital of Harvard Medical School. The Core will be Co-Directed by William Carlezon, Ph.D. and Kerry Ressler, M.D., Ph.D. and has 4 Specific Aims. For Aim 1, the Core will coordinate, integrate, and advance Center research, taking responsibility for the overall coordination of 5 research groups comprising the SPARED Center, and direct the Education, Training, Outreach, and Statistics components. Core Leaders will work directly with the directors of the Education, Training, and Outreach initiative and Statistics/Data Management component. For Aim 2, the Core will create and maintain a SPARED Center website devoted to the Center and establish a social media presence so that our work will have a global reach. The Core will use these resources to disseminate our work to target audiences of scientists and health care practitioners, students (K-12, college, medical school, and graduate students), educators, NIMH “Outreach Partners”, and the general lay-public. For Aim 3, the Core will provide multiple career-building opportunities for early-career scientists conducting SPARED Center-related research, including Seed Grants and Travel Awards. In addition, we will organize a SPARED Center Symposium for faculty and international stress leaders to present their work. We will also encourage SPARED Center faculty to submit symposia proposals to relevant scientific meetings (e.g., SfN, ACNP, SOBP) and provide an educational platform that supports development and teaching new courses. For Aim 4, the Core will share our collective enthusiasm and expertise with the larger community through outreach. Our outreach mission will focus on initiatives aimed at the public and students (K-12 and college), by continuing our ongoing collaboration with the Boston Museum of Science and developing a new outreach pipeline with regional liberal arts colleges by sending SPARED Center faculty to give research talks, meet with students, and recruit future investigators. Thus the Core will support the research mission while enhancing career development and maximizing the impact of the work for experts and lay-persons.

摘要：行政核心 Silvio O. Conte应激肽中心高级研究，教育和传播（遗漏） 麦克莱恩医院将创建一个创新，多学科和全面的研究计划 临床前和临床成分，以阐明不受管制的压力触发精神病的机制 疾病。这5个主题链接的项目将集中于CRF（皮质激素释放因子）之间的相互作用 和PACAP（垂体腺苷酸环化酶激活多肽），辣椒与压力反应性有关 以及包括PTSD在内的使人衰弱的疾病的发展。为了支持这项研究任务，行政 核心将维护实现成功沟通，集成， 以及在不幸的中心项目之间合作，提供了一种经常更新和确保的机制 有效分配和利用资源，以最大程度地提高协同和科学进步。核心 还将支持麦克莱恩（McLean）发展未来研究人员所需的教育和培训活动 领导者是哈佛医学院的主要精神病医院。核心将由 威廉·卡勒宗（William Carlezon）博士和医学博士Kerry Ressler博士并具有4个具体目标。对于目标1，核心将 协调，集成和高级中心研究，负责5个总体协调 完成豁免中心的研究小组，指导教育，培训，外展和统计数据 成分。核心领导者将直接与教育，培训和外展计划的董事合作 和统计/数据管理组件。对于AIM 2，核心将创建和维持一个不幸的中心 专门用于中心并建立社交媒体存在的网站，以便我们的工作具有全球影响力。 核心将利用这些资源来传播我们的工作，以针对科学家和卫生保健的受众 从业者，学生（K-12，大学，医学院和研究生），教育工作者，nimh“外展 合作伙伴”，以及一般的外行公共。对于AIM 3，核心将为多个职业建设机会 早期职业科学家进行了与中心有关的研究，包括种子赠款和旅行奖。 此外，我们将组织一个为教师和国际压力领导者提供的不幸中心研讨会 他们的工作。我们还将鼓励不幸的中心教师向相关科学提交研讨会建议 会议（例如SFN，ACNP，SOBP），并提供一个支持发展和教学的教育平台 新课程。对于AIM 4，核心将与更大的社区分享我们的集体热情和专业知识 通过宣传。我们的外展任务将重点关注针对公众和学生的举措（K-12和 大学），通过继续与波士顿科学博物馆的持续合作并开发新的合作 通过派遣不幸的中心教职员工进行研究会谈， 与学生会面，并招募未来的调查人员。核心将支持研究任务 增强职业发展，并最大程度地提高工作对专家和专家的影响。