In Vivo Photoactoustic Sensing of Lipid Laden Plaque

脂质斑块的体内光声传感

• 批准号: 9114157
• 负责人: Ji-Xin Cheng
• 金额: $ 47.82万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9114157
• 关键词: 3-Dimensional; Acute myocardial infarction; Algorithms; Angiography; Area; Arterial Fatty Streak; Arteries; Arteriogram; Arts; Atherogenic Diet; Atherosclerosis; Autopsy; Blood; Blood Vessels; Blood flow; Caliber; California; Cardiovascular system; Catheters; Chemicals; Cholesterol; Cholesterol Esters; Classification; Clinic; Clinical; Collagen; Coronary; Coronary Arteriosclerosis; Coronary Stenosis; Coronary artery; Detection; Development; Devices; Diagnosis; Doctor of Medicine; Esters; Family suidae; Frequencies; Goals; Health; Histologic; Histology; Human; Image; Imagery; Imaging Device; Imaging Phantoms; In Vitro; Indiana; Inflammation; Inflammatory; Lasers; Lateral; Length; Life; Lipids; Measurement; Measures; Medical; Microscopy; Modality; Modeling; Monitor; Morphologic artifacts; Near-Infrared Spectroscopy; Optical Coherence Tomography; Optics; Patients; Performance; Physicians; Positioning Attribute; Procedures; Real-Time Systems; Research; Resolution; Roentgen Rays; Rotation; Rupture; Signal Transduction; Speed; Stenosis; Stents; Surface; Surgeon; System; Technology; Testing; Therapeutic; Time; Tissues; Ultrasonic Transducer; Ultrasonography; Universities; base; calcification; clinically relevant; data acquisition; design; experience; feeding; imaging system; improved; in vivo; medical schools; miniaturize; novel; photoacoustic imaging; radiofrequency; sensor; spectrograph; tool; virtual

 DESCRIPTION: In current medical treatment of atherosclerosis, a stent is placed for flow-limiting (i.e., >60% stenosis) plaques diagnosed by X-ray based angiography. Revascularization by stenting a flow-limiting coronary artery stenosis has profoundly improved survival. Plaque that is not flow-limiting and thus not stented, however, can be unstable and vulnerable to rupture, which is the major cause of acute myocardial infarction. Currently, no imaging tools exist to diagnose these non-flow-limiting yet potentially vulnerable plaques. The long-term goal of our project is to develop an intravascular vibrational photoacoustic (IVPA) catheter for clinica detection of vulnerable plaques. The objective of this R01 application is to demonstrate an IVPA system for real-time in vivo intravascular visualization of atherosclerotic plaque in a clinically relevant Ossabaw pig model. An interdisciplinary team has been assembled to approach this objective. Dr. Ji-Xin Cheng (Purdue University) is an expert in development and applications of vibrational spectral imaging. Dr. Michael Sturek (Indiana University School of Medicine) is an expert in cardiovascular research. Dr. Qifa Zhou (University of Southern California) is an expert in design and fabrication of ultrasound transducers. Consultant Art Coffey (M.D. in IU Health) is a cardiovascular surgeon who will provide clinical input on the IVPA catheter design. Our central hypothesis is that a high-speed IVPA system allows for in vivo assessment of lipid-rich, inflammatory plaques in an arterial wall. This hypothesis will be tested by 3 Specific Aims. (1) Develop a high-speed IVPA system and demonstrate real-time dual-modality PA/US sensing of an intact atherosclerotic artery in vitro. (2) Differentiate cholesterol crystal (CC) from cholesteol ester (CE)-rich lipid droplets inside an intact artery by spectral analysis of optically induced ultrasound signals. (3) Validate the IVPA system for in vivo assessment of atherosclerotic plaques in an Ossabaw swine model. Successful development of the IVPA system will be able to guide appropriate treatment, e.g. stent deployment, for the lipid-laden, unstable plaque that is not detectable by current intravascular catheters, thus potentially a life-saving technology.

 描述：在目前的动脉粥样硬化治疗中，将支架放置用于通过基于X射线的血管造影诊断的流动限制（即> 60％狭窄）。通过固定流动的冠状动脉狭窄通过置入血运重建，已深刻提高了生存率。然而，不限制且没有支架的斑块可能是不稳定的且容易受到破裂的损害，这是急性心肌违规的主要原因。当前，尚无成像工具来诊断这些非流量限制但潜在的易受伤害的斑块。我们项目的长期目标是开发用于易受伤害斑块的临床检测的血管内振动光声（IVPA）导管。该R01应用的目的是展示一个IVPA系统，用于实时在临床相关的Ossabaw Pig模型中动脉粥样硬化斑块的体内血管内可视化。一个跨学科的团队已被组装以实现这一目标。 Ji-Xin Cheng博士（普渡大学）是振动光谱成像的开发和应用专家。迈克尔·斯特雷克（Michael Sturek）博士（印第安纳大学医学院）是心血管研究的专家。 Qifa Zhou博士（南加州大学）是超声传感器设计和制造专家。顾问Art Coffey（IU Health医学博士）是一名心血管外科医生，他将提供有关IVPA导管设计的临床意见。我们的中心假设是，高速IVPA系统允许对动脉壁中富含脂质的炎症斑块进行体内评估。该假设将通过3个具体目标进行检验。 （1）开发一个高速IVPA系统，并在体外显示了完整动脉粥样硬化动脉的实时双模式PA/US传感器。 （2）通过光谱分析光学诱导的超声信号的光谱分析，将胆固醇晶体（CC）与胆汁硫醇酯（CE） - 富含脂质的脂肪分化。 （3）验证IVPA系统在Ossabaw Swine模型中对动脉粥样硬化斑块的体内评估。 IVPA系统的成功开发将能够指导适当的治疗，例如支架部署，用于富含脂质的，不稳定的斑块 目前的血管内导管无法检测到，因此可能是一种挽救生命的技术。