Training to Enhance Alignment of Psychiatry and Neuroscience

加强精神病学和神经科学协调的培训

• 批准号: 10591484
• 负责人: William A. Carlezon
• 金额: $ 37.65万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10591484
• 关键词: Neurosciences; Psychiatry; Training

SUMMARY This postdoctoral training program at McLean Hospital is designed to address gaps in psychiatry and neuroscience training that limit effective communication across disciplines and translation of discoveries into new treatments. In psychiatry, rapid advances in technology are changing the ways in which psychiatric illness is diagnosed, treated, and studied. In humans, continued refinements in brain imaging, increasing utilization of smart devices, and improvements in the efficiency of genetic tools are among developments enabling fundamentally new insights into healthy and aberrant brain function, as well as molecular factors that contribute to vulnerability to illness. In animal model systems, there has been a corresponding evolution of precision molecular techniques to probe and dissect the neural circuitry underlying motivational and emotional behavior. Despite these advances, psychiatry and neuroscience continue to evolve in parallel, with precious few examples where the fields have aligned to produce transformative changes in human health. One indicator of this parallel evolution is stagnation in development of new treatments; indeed, difficulties in developing CNS drugs with new mechanisms have led to a massive divestment by industry. While many factors contribute to these failures, most are related to a lack of forward- (animal to human) and back- (human to animal) translation of key discoveries, leading to questions about the usefulness of model systems in drug development. Enhancing alignment of psychiatry and neuroscience is critical to invigorate translationally-relevant discoveries in clinical and basic research. With its combined clinical, research, and academic missions, McLean is optimally positioned to play a key role in establishing more impactful interactions between psychiatry and neuroscience. Research occurs in >100 labs across clinical, preclinical, and basic neuroscience programs that are intertwined, in adjacent labs or neighboring buildings, enabling routine interactions among clinicians, neuroscientists, and trainees (residents, postdocs, students). As a freestanding psychiatric hospital—perennially ranked #1 in this category—there is expertise in a broad range of NIMH-relevant domains. McLean has unique attributes, including the Institute for Technology in Psychiatry, to facilitate efforts to align research in humans and animals. This T32 program will provide resources for 6 slots per year to support activities for postdoctoral trainees across a range of experience levels for up to 3 years. The main objectives include (1) exposing a diverse group of trainees with backgrounds in clinical care to basic neuroscience research, and vice-versa, (2) providing comprehensive training that prioritizes emerging technologies such as digital phenotyping, biomarkers, and genetics to enable rigorous study of homologous endpoints in humans and animals, (3) ensuring a balanced experience via dual mentors with complementary expertise, and (4) leveraging the dual mentorship design to train emerging mentors. Progress towards these goals will be overseen by a McLean leadership team and an External Advisory Committee comprising world-renowned experts in psychiatry, neuroscience, training, and therapeutics development.

概括 麦克莱恩医院的该博士后培训计划旨在解决精神病学和 神经科学训练限制了跨学科的有效沟通以及将发现转化为 新治疗。在精神病学中，技术的快速进步正在改变精神病的方式 被诊断，治疗和研究。在人类中，脑成像的持续改进，增加了对 智能设备以及遗传工具效率的提高是实现的发展 从根本上讲，人们对健康和异常大脑功能以及有助于的分子因素有了新的见解 容易患病。在动物模型系统中，精确的相应演变 分子技术探测和剖析动机和情感行为的神经元电路。 尽管取得了这些进步，精神病学和神经科学仍在同时发展，很少有例子 该领域已经对齐以产生人类健康的变革性变化。这个平行的一个指标 进化是新疗法发展的停滞；确实，开发新的CNS药物的困难 机制导致行业大规模撤资。尽管许多因素导致了这些失败，但大多数因素 与缺乏向前（人类的动物）和反向（人向动物）翻译有关的关键发现有关， 导致有关模型系统在药物开发中的实用性的疑问。增强对齐方式 精神病学和神经科学对于在临床和基本的基础上的转换发现至关重要 研究。麦克莱恩（McLean 建立精神病学与神经科学之间更具影响力的互动的关键作用。研究发生 在临床，临床前和基本的神经科学计划中，在> 100个实验室中，在相邻实验室中交织在一起 或邻近的建筑物，使临床医生，神经科学家和学员之间的常规相互作用（居民， 博士后，学生）。作为一家独立的精神病医院 - 该类别中排名第一， 在广泛的NIMH相关领域中的专业知识。麦克莱恩具有独特的属性，包括 精神病学技术，促进对人类和动物的研究的努力。这个T32程序将 为每年6个老虎机提供资源，以支持多种经验的博士后学员的活动 最多3年的水平。主要目标包括（1）揭露具有背景的潜水员群体 在基础神经科学研究的临床护理中，反之亦然，（2）提供全面的培训 优先考虑新兴技术，例如数字表型，生物标志物和遗传学，以实现严格的研究 （3）通过双重导师与人类和动物中的同源终点 完全专业知识，以及（4）利用双重精神设计的设计来培训新兴的精神。进步 达到这些目标将由麦克莱恩领导团队和外部咨询委员会监督 包括世界知名的精神病学专家，神经科学，培训和治疗开发。

项目成果

Cross species review of the physiological role of D-serine in translationally relevant behaviors.

• DOI: 10.1007/s00726-023-03338-6
• 发表时间: 2023-11
• 期刊: Amino acids
• 影响因子: 3.5

Unpacking the Biases That Shape the Apparent Foci in the Meta-analysis of Voxel-Based Neuroimaging Studies.

在基于体素的神经影像研究的荟萃分析中揭示形成明显病灶的偏差。

• DOI: 10.1016/j.biopsych.2022.06.021
• 发表时间: 2022
• 期刊: Biological psychiatry
• 影响因子: 10.6
• 作者: Chung,Yoonho

The link between static and dynamic brain functional network connectivity and genetic risk of Alzheimer's disease.

• DOI: 10.1016/j.nicl.2023.103363
• 发表时间: 2023
• 期刊: NEUROIMAGE-CLINICAL
• 影响因子: 4.2
• 作者: Sendi, Mohammad S. E.;Zendehrouh, Elaheh;Ellis, Charles A.;Fu, Zening;Chen, Jiayu;Miller, Robyn L.;Mormino, Elizabeth C.;Salat, David H.;Calhoun, Vince D.
• 通讯作者: Calhoun, Vince D.

Early life stress in male mice blunts responsiveness in a translationally-relevant reward task.

• DOI: 10.1038/s41386-023-01610-7
• 发表时间: 2023-11
• 期刊: NEUROPSYCHOPHARMACOLOGY
• 影响因子: 7.6
• 作者: Hisey, Erin E.;Fritsch, Emma L.;Newman, Emily L.;Ressler, Kerry J.;Kangas, Brian D.;Carlezon Jr, William A. A.
• 通讯作者: Carlezon Jr, William A. A.

Building an intentional and impactful summer research experience to increase diversity in mental health research.

• DOI: 10.1038/s41386-022-01461-8
• 发表时间: 2022-12
• 期刊: NEUROPSYCHOPHARMACOLOGY
• 影响因子: 7.6
• 作者: Folorunso, Oluwarotimi O.;White, Karen Burns;Alonso-Caraballo, Yanaira;Nowicki, Genevieve P.;Olson, Elizabeth A.;Pizzagalli, Diego A.;Carlezon, William A.;Ressler, Kerry J.;Chartoff, Elena H.
• 通讯作者: Chartoff, Elena H.