Core-001

核心001

• 批准号: 10198070
• 负责人: David H Ellison
• 金额: $ 68.71万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-02 至 2022-08-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10198070
• 关键词: Bioinformatics; Clinical; Clinical Research; Clinical Trials; Communities; Data; Data Science; Data Security; Ethics; Image; Informatics; Infrastructure; Investments; Methods; Modality; Modeling; Oregon; Patient Recruitments; Process; Reproducibility; Research; Research Institute; Scientist; Services; Solid; Training; Translational Research; Work; base; clinical care; cohort; community engagement; data reuse; data sharing; data standards; data warehouse; human subject protection; improved; industry partner; informatics training; innovation; interoperability; member; multidisciplinary; novel; privacy preservation; social health determinants; translational pipeline

The OCTRI Informatics Core has been accelerating clinical and translational research at OHSU, our CTSA Consortium partners, and the broader research community by creating innovative informatics methods, infrastructure, and services since 2006, as a member of the original CTSA cohort. These informatics methods and services cover the translational spectrum from translational bioinformatics, clinical research informatics, and community engagement. With a solid grounding in academic and applied informatics, the OCTRI Informatics Core has provided training to a diverse array of translational workforce members. Building on this prior work, the Informatics Core will further catalyze clinical and translational research through the following aims: Specific Aim 1: Develop and implement novel, targeted informatics approaches to solve translational research bottlenecks and enable new research modalities. Specific Aim 2: Collaborate with other CTSAs as well as other broad-based efforts to improve utilization and extension of data standards, interoperability, and data sharing and security models. Specific Aim 3: Provide training to the translational research workforce in informatics and data science best practices, focused on data and methods dissemination, data re-use, rigor, and reproducibility. A key component of our strategy is to target specific high-impact research bottlenecks through a collaborative, integrative, and multidisciplinary process including scientists, informaticians, IT experts, clinicians, experts in ethics and human subjects protection, community members, and other stakeholders. We will catalyze research by developing and supporting new informatics approaches that integrate the clinical care and research enterprises, and facilitate the recruitment of patients into clinical trials, both regionally and across the CTSA network. We will greatly enrich our already mature data warehouse to incorporate a broader array of data types (e.g., imaging, -omics, social determinants of health) as well as data from our growing partner network. We will leverage OHSU’s investment and commitment to informatics governance, industry partnerships, and human subjects protection expertise to develop innovative, privacy-preserving data sharing methods grounded in informatics concepts and ethical principles. As a leader in training informatics professionals and educating the nation’s workforce in informatics, we will bring new and unique educational opportunities to the nation’s clinical and translational workforce.

OCTRI 信息学核心一直在加速 OHSU（我们的 CTSA）的临床和转化研究 联盟合作伙伴和更广泛的研究界通过创建创新的信息学方法， 自 2006 年起，作为最初 CTSA 群体的成员，我们开始致力于基础设施和服务的开发。 服务涵盖转化生物信息学、临床研究信息学、 OCTRI 拥有扎实的学术和应用信息学基础。 在此基础上，信息学核心为各类翻译人员提供了培训。 在之前的工作中，信息学核心将通过以下方式进一步促进临床和转化研究 目标： 具体目标 1：开发和实施新颖的、有针对性的信息学方法来解决转化研究 瓶颈并启用新的研究模式。 具体目标 2：与其他 CTSA 以及其他广泛的努力合作，以提高利用率和 数据标准、互操作性以及数据共享和安全模型的扩展。 具体目标 3：为信息学和数据科学领域的转化研究人员提供最佳培训 实践，侧重于数据和方法传播、数据重用、严谨性和可重复性。 我们战略的一个关键组成部分是通过协作、 综合的、多学科的过程，包括科学家、信息学家、IT 专家、 我们将促进研究的道德和人类受试者保护、社区成员和其他利益相关者。 通过开发和支持整合临床护理和研究的新信息学方法 企业，并促进区域和整个 CTSA 招募患者参加临床试验 我们将极大地丰富我们已经成熟的数据仓库，以纳入更广泛的数据类型。 （例如，成像、组学、健康的社会决定因素）以及来自我们不断增长的合作伙伴网络的数据。 利用 OHSU 对信息学治理、行业合作伙伴关系和人力的投资和承诺 主题保护专业知识开发创新的、保护隐私的数据共享方法 作为培训信息学专业人员和教育信息学的领导者。 国家信息学劳动力，我们将为国家临床带来新的、独特的教育机会 和翻译劳动力。