Core-005

核心005

• 批准号: 10198074
• 负责人: David H Ellison
• 金额: $ 164.5万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-02 至 2022-08-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10198074
• 关键词: Address; Adopted; Area; Center for Translational Science Activities; Child Health; Clinical; Clinical Research; Development; Disease; Ensure; Ethics; Evaluation; Evolution; Foundations; Funding; Goals; Growth; Health; Human; Impairment; Intervention; Knowledge; Laboratories; Learning Module; Longevity; Mentors; Modeling; Older Population; Oregon; Participant; Performance; Personal Satisfaction; Phenotype; Process; Research; Research Institute; Research Personnel; Resource Sharing; Rural Population; Site; Special Population; Structure; Students; Techniques; Therapeutic; Translational Research; Universities; career development; early phase clinical trial; human disease; improved; informatics tool; patient oriented research; programs; research study; rural underserved; stressor; symposium

OHSU has a robust research portfolio in child health, older populations, diseases across the lifespan, and underserved rural populations. However, there are significant gaps in coordinated support for these important programs that impair optimal performance and expansion of these efforts. The new OCTRI Integrating Special Populations unit (ISP) will enhance research in child health, older populations, diseases across the lifespan, and underserved rural populations with a critical analysis of current needs, development of feasible goals to address these needs, implementation of the highest priority goals, and evaluation and dissemination of the most effective processes. Planned activities include regional conferences and retreats with investigators and other stakeholders, development of toolkits and other educational modules, enhanced informatics tools, and other techniques tailored to each program. The ISP will coordinate closely with the CTSA network to adopt effective techniques developed at other CTSA sites, and to share local proven techniques after careful evaluation. These efforts will enhance knowledge of health-related issues in these special populations, leading to improved interventions to optimize their health and well-being. The OCTRI Clinical and Translational Research Center (CTRC) has greatly expanded and enhanced the conduct of clinical research at OHSU, with unprecedented growth over the past five years. The CTRC also serves as a major site for career development in clinical research at OHSU. However, stressors on CTRC operational and financial structures require a new funding model and increased operational efficiencies. These accomplishments and challenges set the stage for continued evolution of OCTRI’s Participant and Clinical Interactions (PCI) research capacity for the next five years. The CTRC will catalyze scientifically rigorous, ethical, feasible, and efficient patient-oriented research studies, with an emphasis on intensive phenotyping and early phase clinical trials in high priority areas for OHSU investigators. These efforts will advance knowledge of numerous human diseases and lay the foundations for disease-specific therapeutics to enhance human health. The CTRC will also continue to leverage and enhance the OCTRI Educational Program by utilizing the CTRC as the mentored “laboratory” for students, investigators, and study staff pursuing patient- oriented research. Finally, the CTRC will complete its transition to a new operational model as a University Shared Resource (USR), incorporating continuous quality improvement to ensure that sustainable and efficient operational and financial processes are in place to optimally support PCI research at OHSU and the region.

OHSU在儿童健康方面拥有强大的研究组合，较老的人群，整个寿命的疾病以及 服务不足的农村人口。但是，对这些的协调支持存在很大的差距 损害最佳绩效和扩展这些努力的重要计划。新的Octri 整合特殊人口单位（ISP）将增强儿童健康研究，较老的人群，疾病 在整个生命周期，以及服务不足的农村人群，对当前需求进行批判性分析，发展 解决这些需求的可行目标，实施最高优先级目标以及评估和 传播最有效的过程。计划的活动包括区域会议和务虚会 随着调查人员和其他利益相关者的发展，工具包和其他教育模块的发展，增强了 信息工具和针对每个程序量身定制的其他技术。 ISP将与 CTSA网络采用在其他CTSA网站开发的有效技术，并分享本地验证的 仔细评估后的技术。这些努力将增强与健康相关问题的知识 特殊人群，导致改进的干预措施以优化其健康和福祉。 OCTRI临床和转化研究中心（CTRC）大大扩展和增强了 在OHSU进行临床研究，在过去五年中，始终增长了。 CTRC也是如此 是OHSU临床研究职业发展的主要网站。但是，CTRC的压力源 运营和金融结构需要新的资金模型并提高运营效率。 这些成就和挑战为OCTRI参与者的持续发展奠定了基础 未来五年的临床相互作用（PCI）研究能力。 CTRC将科学催化 严格，道德，可行，有效的面向患者的研究，重点是密集型 OHSU研究人员的高优先级领域的表型和早期临床试验。这些努力会 提前了解许多人类疾病并为疾病特异性治疗奠定基础 增强人类健康。 CTRC还将继续利用和增强OCTRI教育 通过使用CTRC作为学生，调查人员和学习人员的“实验室”来计划 追求以患者为导向的研究。最后，CTRC将完成其过渡到新的运营 作为大学共享资源（USR）的模型，纳入了持续的质量改进，以确保 可持续有效的运营和财务流程已适当以最佳支持PCI OHSU和该地区的研究。