Penn State University's Translational Center for Child Maltreatment Studies TCCMS

宾夕法尼亚州立大学儿童虐待研究转化中心 TCCMS

• 批准号: 10187605
• 负责人: JENNIE G NOLL
• 金额: $ 172.8万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-20 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10187605
• 关键词: Academy; Active Learning; Address; Advocate; Age; American; Behavioral; Behavioral Mechanisms; Biological; Brain; Centers for Disease Control and Prevention (U.S.); Cessation of life; Child; Child Abuse; Child Abuse and Neglect; Child Welfare; Childhood; Clinical; Clinical Trials; Cluster randomized trial; Communities; Complex; Country; Craniocerebral Trauma; Data; Data Analytics; Detection; Development; Economic Burden; Economics; Emotional; Ensure; Etiology; Evaluation; Exposure to; Future Generations; Health; Human; Illusions; Immunologics; Injury; Institute of Medicine (U.S.); Intervention; Investments; Knowledge; Laws; Leadership; Longitudinal cohort study; Maintenance; Malignant Childhood Neoplasm; Mentors; Methods; Modeling; Neurosecretory Systems; Obesity; Outcome; Pathway interactions; Pediatrics; Pennsylvania; Personal Satisfaction; Physicians; Play; Policies; Policy Maker; Politics; Predictive Analytics; Prevention; Process; Prospective cohort study; Provider; Public Health; Recommendation; Research; Research Project Grants; Resources; Role; Savings; Science; Scientist; Services; Shaken baby syndrome; Smoking; Social Change; Statutes and Laws; Students; Survivors; System; Testing; Translating; Translational Research; Trauma patient; Universities; Work; aged; behavioral health; brain health; child protection; clinical practice; cohort; community based participatory research; cost; data dissemination; data repository; design; dynamic system; economic impact; epigenomics; evidence base; experience; health disparity; high risk; implementation facilitation; implementation strategy; innovation; maltreated children; maltreatment; mortality; neurobiological mechanism; next generation; novel; outreach; physical conditioning; predictive modeling; prevent; prospective; public health relevance; research study; resilience; scaffold; tool

The Translational Center for Child Maltreatment Studies (TCCMS) at Penn State will increase the rigor and quality of research conducted in the field of child maltreatment via exciting research projects and cores. Through a large-scale partnership with the State of Pennsylvania's Department of Human Services, Project 1 is a prospective cohort study of 1200 maltreated and comparison children aimed at elucidating the multiple etiological processes believed to play a role in the onset and maintenance of adverse health outcomes for victims. By using state-of-the-art assessment methods across multiple levels of analysis—neuroendocrine, autonomic, epigenomic, immunological, behavioral, familial, contextual, and several aspects of resilience— Project 1 will identify the putative and protective mechanisms of subsequent health outcomes, including physical health, behavioral health, and brain development. This rigorous science will significantly advance knowledge of the complex interplay between biological and behavioral mechanisms responsible for health disparities in maltreatment victims and illuminate avenues for promoting resilience and opportunities for reversibility. Project 2 is stratified cluster randomized trial (SCRT) of a Clinical Decision Rule (CDR) for Abusive Head Trauma (AHT) designed to increase child abuse evaluations of high-risk head trauma cases and saving lives where AHT is currently unrecognized. This SCRT will comprise 416 AHT patients aged 0-3 in 8 Pediatric ICUs across the country. Project 2 also includes a sustainability trial of implementation strategies utilizing another 104 AHT patients. By translating high-quality science into fiscal messages that will leverage legislative action, the TCCMS's Dissemination and Outreach Core (DOC) will develop a national model for advancing the basic, yet illusive, tenet of science as a vehicle for impacting and mobilizing social change. Using administrative data the DOC will employ predictive analytics to craft translational messages about the economic impact of child maltreatment. The DOC will also use predictive models to translate knowledge generated in Projects 1 & 2 into compelling fiscal messages regarding the public costs incurred by maltreated children in the Project 1 cohort, and the Return-On-Investment of implementing the Project 2 CDR. By engaging community providers, the DOC will use a Community-based Participatory Research (CBPR) model to devise and test workable solutions to facilitate implementation of child welfare reform. The DOC will package TCCMS research into products that will entreat increased public investment. The Admin Core will maximize and accelerate TCCMS impact by ensuring that its research and products receive high-level exposure to the public and to policy leaders. The Admin Core will serve as a national model for growing new science and nurturing budding scientists through access to a national data repository and innovative experiential learning forums. The TCCMS will emerge as THE premier center where transdisciplinary scientists work together with practitioners and policy-makers to implement solutions to the complex problem of child maltreatment.

宾夕法尼亚州儿童虐待研究（TCCMS）的转化中心将增加严格和 通过激动人心的研究项目和核心在儿童虐待领域进行的研究质量。 通过与宾夕法尼亚州人类服务部的大规模合作，项目1 是一项针对1200种虐待和比较儿童的前瞻性队列研究，旨在阐明多个 据信的病因过程在不良健康结果的发作和维持中发挥作用 通过使用跨多个分析的最先进的评估方法 - 否内分泌， 自主，表观基因组，免​​疫学，行为，家族，情境和韧性的几个方面 - 项目1将确定随后的健康结果的推定和受保护的机制，包括 身体健康，行为健康和大脑发育。这种严格的科学将大大发展 了解负责健康的生物学和行为机制之间的复杂相互作用 虐待的差异令人恐惧和照亮途径，以促进韧性和机会 可逆性。项目2是临床决策规则（CDR）的分层群集随机试验（SCRT） 虐待头部创伤（AHT）旨在增加对高风险头部创伤病例的儿童虐待评估和 挽救当前无法识别的AHT的生命。该SCRT将完成416名AHT患者，年龄在8中为0-3 全国各地的小儿ICU。项目2还包括实施策略的可持续性试验 使用另外104名AHT患者。通过将高质量的科学转化为会利用的财政信息 立法行动，TCCMS的传播和外展核心（DOC）将开发一个国家模式 推进科学的基本但易用的宗旨，作为影响和动员社会变革的工具。 使用管理数据，文档将采用预测分析来制作有关该信息的翻译信息 儿童虐待的经济影响。文档还将使用预测模型来翻译知识 在项目1和2中产生的有关虐待所产生的公共费用的引人注目的财政信息 项目1队列中的儿童，以及实施项目2 CDR的投资回报。经过 参与社区提供商，该文档将使用基于社区的参与性研究（CBPR）模型来 设计和测试可行的解决方案，以促进实施儿童福利改革。文档将包装 TCCMS对将提高公共投资的产品的研究。管理员核心将最大化 并通过确保其研究和产品获得高级接触来加速TCCM的影响 公共和政策领导者。管理员核心将成为发展新科学的国家模式， 通过获得国家数据存储库和创新专家学习来培养萌芽的科学家 论坛。 TCCM将成为跨学科科学家与之合作的主要中心 从业者和政策制定者实施解决复杂儿童虐待问题的解决方案。