Daily Stress Coping and Premature Cognitive Aging in Child Abuse Victims at Midfi

Midfi 儿童虐待受害者的日常压力应对和认知过早老化

• 批准号: 8795539
• 负责人: JENNIE G NOLL
• 金额: $ 29.89万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-30 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8795539
• 关键词: Accounting; Adolescence; Adrenal Glands; Affect; Age; Attention; Attenuated; Automobile Driving; Award; Cereals; Characteristics; Child; Child Abuse; Child Abuse and Neglect; Childhood; Chronic; Chronic stress; Cognitive; Cognitive aging; Collection; Consultations; Coupled; Data; Data Collection; Dementia; Development; Devices; Doctor of Philosophy; Elderly; Exhibits; Female; Funding; Growth and Development function; Health; Health Expenditures; Hormones; Human; Hypothalamic structure; Individual; Intervention; Knowledge; Language; Life; Light; Liquid substance; Longevity; Measurement; Mediating; Methodology; Modeling; National Institute of Child Health and Human Development; Outcome; Parents; Participant; Physiological; Pituitary Gland; Populations at Risk; Process; Property; Protocols documentation; Psychopathology; Public Health; Research; Retrieval; Risk; Role; Sampling; Sexual abuse; Short-Term Memory; Signal Transduction; Stress; Stress and Coping; Tablets; Temperament; Testing; Time; Variant; abuse neglect; abuse victim; aged; allostatic load; behavioral health; biological adaptation to stress; cohort; coping; design; diaries; early adolescence; emerging adult; global health; hypothalamic-pituitary-adrenal axis; innovation; insight; interdisciplinary collaboration; long term memory; middle age; novel; outcome forecast; physical conditioning; premature; processing speed; prospective; public health relevance; resilience; response; social; stressor; theories; trend

 DESCRIPTION (provided by applicant): Reversing the impact of early, chronic adversity is of paramount importance given that over one million children are victims of abuse and neglect each year in the US and that child maltreatment is estimated to account for billions in public health expenditures. The physiological wear and tear of early-life adversity has recently received considerable attention; however, supporting evidence in humans is limited because long-term health and cognitive outcomes have not yet been prospectively examined in stress-exposed samples. The Female Growth and Development Study (FGDS) began in 1987 and the PI (Jennie Noll, PhD) has retained 96% of this sample of females with substantiated sexual abuse and matched comparisons (N=173) in an accelerated longitudinal, cross-sequential design spanning 6 time points (T1-T6). A multi-level, comprehensive, bio-psycho- social assessment was repeated three times in childhood/early adolescence (mean ages 11, 12 & 13), twice in late adolescence (mean ages 18 & 19), and once in early adulthood (mean age 24). Recently, FGDS was awarded additional funding from NICHD to conduct T7 and T8 assessments when the sample will be mean aged 38 and 40 respectively. FGDS Aims have not been extended to examine resilience in the face of daily stressors or the extent to which daily stressors exacerbate the impact of an already-compromised Hypothalamic Pituitary Adrenal (HPA) axis. Moreover, analytic projections indicate that, if trends continue, the abused cohort may be exhibiting signs of premature cognitive aging but the funded cognitive assessment lacks the precision to fully detect this phenomenon. New data collection as part of the proposed RFA-protocol would add (1) ecologically valid inquiry into resilient versus maladaptive coping with daily life stressors, (2) fine- grained cognitive assessments (i.e., working memory, attention inhibition, processing speed, fluid reasoning, associative memory and long-term retrieval) that prognosticate premature cognitive aging, and (3) potentially malleable behavioral health targets that could be intervened upon to reverse the impact of allostatic load on long-term physical and cognitive wellbeing. In addition, the proposed innovative analytic approach will utilize extant data from T1-T8 to test the static and dynamic mechanistic properties of risk and resilient bio-psycho- social constructs, as well as potentially malleable behavioral health targets that account for individual variation in daily stress-coping and cognitive health at midlife. Resultant models will illuminate key points in development where novel interventions promoting stress inoculation and cognitive plasticity could be optimally applied to reverse the deleterious effects of early adversity.

 描述（由适用提供）：逆转早期，慢性逆境的影响至关重要，因为超过一百万的儿童是美国每年遭受虐待和忽视的受害者，并且估计儿童虐待估计有数十亿美元的公共卫生支出。早期广告的身体磨损最近受到了考虑的关注。但是，人类的支持证据受到限制，因为长期健康和认知结果尚未在暴露于压力的样本中进行前瞻性检查。女性成长和发展研究（FGD）始于1987年，PI（Jennie Noll，PhD）保留了这种具有证实性虐待的女性样本，并在加速的纵向，跨序列的设计跨度设计中，匹配性虐待和匹配的比较（n = 173）（n = 173）。在儿童/青春期早期（平均年龄11、12和13岁），在青春期后期两次（平均18岁和19岁），重复了三次多层次，全面的生物心理社会评估，并在成年初（平均年龄24岁）重复进行。最近，当样本分别为38岁和40岁时，FGD被授予NICHD的额外资金进行T7和T8评估。 FGD的目标尚未扩展到面对每日损失或日常压力源加剧已经受到强化的下丘脑垂体肾上腺（HPA）轴的影响程度的弹性。此外，分析项目表明，如果趋势继续下去，滥用的队列可能表现出早熟衰老的迹象，但是最终的认知评估缺乏完全检测到这种现象的精确度。作为拟议的RFA协议的一部分，新的数据收集将增加（1）对耐药性与不良适应性应对的有效询问，（2）细粒度的认知评估，（即，工作记忆，工作记忆，注意力抑制，处理速度，流动速度，流动性，相关的记忆力和长期检索的启发，可能促进了稳定的型号，并具有较早的稳定性，并具有稳定的效果，并具有稳定的效果（3）在扭转同种异体负荷对长期身体和认知健康的影响之后。此外，提出的创新分析方法将利用T1-T8的额外数据来测试风险和弹性的生物心理结构的静态和动态机械性能，以及潜在的可延展的行为健康目标，以说明Midlife日常应激和认知健康的个人变化。最终的模型将阐明开发中的关键点，在这些过程中，可以最佳地应用促进应力接种和认知可塑性的新干预措施来扭转早期广告的有害影响。