Comparison of Weight Loss Induced by Intermittent Fasting Versus Daily Caloric Restriction in Individuals with Obesity: A 1-Year Randomized Trial

肥胖个体间歇性禁食与每日热量限制引起的体重减轻的比较：一年随机试验

• 批准号: 10187552
• 负责人: VICTORIA A CATENACCI
• 金额: $ 64.37万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10187552
• 关键词: Adherence; Adult; Appetite Regulation; Attention; Behavioral; Biological; Blood Pressure; Body Composition; Body Weight; Body Weight Changes; Body Weight decreased; Caloric Restriction; Calories; Clinical Data; Data; Desire for food; Diet; Dietary Intervention; Effectiveness; Energy Intake; Energy Metabolism; Fatty acid glycerol esters; Foundations; Guidelines; Health; Hormones; Hour; Individual; Intake; Intermittent fasting; Intervention; Intervention Trial; Lipids; Literature; Maintenance; Measures; Mediating; Metabolic; Methods; Obesity; Outcome; Overweight; Participant; Patient Self-Report; Patients; Pattern; Physical activity; Pilot Projects; Public Health; Research; Research Design; Rest; Risk; Thinness; Time; Weight; base; clinically significant; clinically translatable; design; dietary; dietary adherence; dietary approach; doubly-labeled water; energy balance; evidence base; follow-up; group intervention; improved; innovation; insulin sensitivity; moderate-to-vigorous physical activity; novel; obesity treatment; oxidation; pragmatic trial; preservation; programs; psychosocial; randomized trial; responders and non-responders; sedentary; sedentary lifestyle; standard of care; success; total energy expenditure; treatment strategy; trial design; weight loss program

Project Summary/Abstract Restricting daily calorie intake is the primary dietary strategy currently used to treat obesity. However, this approach is not effective for all individuals. Further, adherence to daily caloric restriction (DCR) typically decreases over time and many individuals who lose weight with this strategy will regain. Thus, novel dietary interventions are needed to provide a broader range of treatment options. The objective of this proposal is to determine if intermittent fasting (IMF) is an effective dietary strategy for treatment of obesity. IMF is an alternative method of reducing energy intake (EI) which has gained lay popularity in recent years as a strategy for weight loss. Short-term studies suggest IMF produces 3-8% weight loss in individuals with overweight and obesity. However, few studies have compared IMF to DCR and no studies have evaluated whether IMF is an effective long-term (≥1 year) weight loss strategy. Data from an 8-week pilot study comparing IMF to DCR suggests IMF is safe, tolerable, and produces similar short-term weight loss. After 6 months of unsupervised follow-up, changes in body composition tended to be more favorable with IMF and almost twice as many IMF participants maintained a ≥5 kg weight loss. Thus, IMF may be a more effective dietary strategy for sustaining weight loss than DCR. However, longer-term data are needed and little is known about adherence to IMF or the impact of IMF on energy expenditure (EE). Short-term studies suggest adherence to IMF may be superior to DCR, however, energy intake (EI) was based on self-report which may have significant limitations. Pilot data suggests resting energy expenditure (REE) was preserved during IMF-induced weight loss, which could decrease risk for weight regain. However, the impact of IMF on other components of EE including physical activity (PA) is largely unexamined. The study design is a pragmatic 1-year randomized trial to compare weight loss generated by IMF vs DCR. The targeted weekly energy deficit will be equivalent: DCR will be prescribed a 30% daily energy restriction and IMF will be prescribed a modified fast (75% energy restriction) on 3 non-consecutive days per week. The hypothesis is that a weight loss program based on IMF as the primary dietary strategy will result in greater weight loss at 1 year compared to a program based on traditional DCR. Aim 1 will compare weight loss and changes in body composition and metabolic parameters induced by IMF and DCR at 1 year. Aim 2 will evaluate the impact of IMF (compared to DCR) on EI and dietary adherence. Aim 3 will evaluate the impact of IMF (compared to DCR) on components of EE and patterns of PA. Aim 4 will explore predictors of weight loss within both IMF and DCR. The approach is innovative as the targeted energy deficit will be matched between groups and EI will be assessed objectively (using doubly-labeled water) to provide an accurate comparison of adherence. In addition, both intervention groups will receive guidelines-based behavioral support to compare IMF to the current standard of care (DCR) in a more robust fashion. This study is significant as it could identify an effective alternative dietary strategy to help more people achieve and sustain weight loss. !

项目摘要/摘要 限制每日卡路里摄入量是目前用于治疗肥胖症的主要饮食策略。但是，这个 方法对所有个人都不是有效的。此外，遵守日常热量限制（DCR） 随着时间的流逝，减少体重的许多人将继续进行。那是新颖的饮食 需要干预措施以提供更广泛的治疗选择。该提议的目的是 确定间歇性禁食（IMF）是否是治疗肥胖症的有效饮食策略。 IMF是另一种选择 减少能源摄入量（EI）的方法，该方法近年来已成为体重的策略 损失。短期研究表明，IMF在超重和肥胖者中产生3-8％的体重减轻。 但是，很少有研究将IMF与DCR进行了比较，没有研究评估IMF是否有效 长期（≥1年）减肥策略。来自为期8周的试点研究的数据，将IMF与DCR进行了比较，这表明IMF 是安全，可耐受的，并且会产生类似的短期体重减轻。经过6个月的无监督随访， 人体成分的变化往往对IMF更有利，几乎是IMF参与者的两倍 保持≥5公斤的体重减轻。这是IMF可能是维持体重减轻的更有效的饮食策略 比DCR。但是，需要长期数据，对IMF的遵守或对IMF的影响知之甚少 国际货币基金组织有关能源支出（EE）。短期研究表明，遵守IMF可能优于DCR， 但是，能量摄入量（EI）是基于自我报告的，这可能会有很大的限制。试点数据建议 在IMF引起的体重减轻期间保留了静息能量支出（REE），这可能会降低 体重仍然存在。但是，IMF对包括体育锻炼（PA）在内其他EE组件的影响很大 未经检查。研究设计是一项务实的1年随机试验，以比较IMF产生的减肥 vs dcr。有针对性的每周能量不足将是等效的：DCR将被处方30％的每日能量 限制和国际货币基金组织将在3个非连续天的快速（75％能量限制）处方。 星期。假设是基于IMF作为主要饮食策略的减肥计划将导致 与基于传统DCR的计划相比，1年时的体重减轻更大。 AIM 1将比较减肥 以及IMF和DCR在1年诱导的人体组成和代谢参数的变化。 AIM 2意志 评估IMF（与DCR相比）对EI和饮食依从性的影响。 AIM 3将评估 IMF（与DCR相比）在EE和PA模式的组件上。 AIM 4将探索减肥的预测指标 在IMF和DCR中。该方法具有创新性，因为目标能源防御将在 组和EI将客观评估（使用双标签水），以提供准确的比较 坚持。此外，两个干预组将获得基于指南的行为支持以比较 IMF以更强大的方式达到当前的护理标准（DCR）。这项研究很重要，因为它可以识别 一种有效的替代饮食策略，可以帮助更多的人实现和维持体重减轻。 呢

项目成果

Pattern-based clustering of daily weigh-in trajectories using dynamic time warping.

• DOI: 10.1111/biom.13773
• 发表时间: 2023-09
• 期刊: BIOMETRICS
• 影响因子: 1.9
• 作者: Bothwell, Samantha;Kaizer, Alex;Peterson, Ryan;Ostendorf, Danielle;Catenacci, Victoria;Wrobel, Julia
• 通讯作者: Wrobel, Julia