Core C: Biostatistical Core

核心 C：生物统计核心

• 批准号: 9982229
• 负责人: GRAHAM A. COLDITZ
• 金额: $ 15.26万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9982229
• 关键词: Adverse event; Area; Basic Science; Bioinformatics; Biological Assay; Biological Markers; Biometry; Biostatistics Core; Cancer Center; Clinical; Clinical Research; Clinical Trials; Collaborations; Complement; Comprehensive Cancer Center; Consult; Consultations; Data; Data Analyses; Data Analytics; Data Collection; Database Management Systems; Databases; Development; Ensure; Epidemiologist; Epidemiology; Exposure to; Faculty; Genetic; Genome; Genomics; Goals; Individual; Informatics; Knowledge acquisition; Leadership; Link; Malignant neoplasm of pancreas; Methods; Minority; Monitor; Names; Nurses; Output; Pilot Projects; Process; Quality Control; Randomized Controlled Clinical Trials; Reporting; Research; Research Design; Research Methodology; Research Personnel; Resource Sharing; Resources; Sampling; Technology; Testing; Tissue Procurements; Universities; Washington; base; career development; chemotherapy; computerized; computerized data processing; data management; data quality; database design; design; epidemiology study; experience; genomic data; laboratory experiment; leukemia; medical schools; meetings; member; programs; recruit; research study; scientific computing; synergism; tool; translational clinical trial

PROJECT SUMMARY The Biostatistics Core (BC) provides the statistical design, data management, and computational support for all Pancreatic Cancer SPORE investigators. The BC will support consultation and collaboration on all aspects of study design, database development and quality control, as well as analysis and interpretation of data. The statisticians participating in the Biostatistics Core have been chosen for their broad range of expertise and experience in clinical trials, laboratory experiments, genetics and genomics research, and epidemiology studies. Dr. Graham Colditz and Dr. Esther Lu (formerly named Jingxia Liu) have extensive experience as investigators and statisticians within the comprehensive cancer center setting. For example, Dr. Feng Gao has collaborated with Dr. Wang-Gillam (Clinical Co-Leader on Project 3) on her ongoing randomized controlled clinical trials of chemotherapy for the treatment of pancreatic cancer. They are supported by staff with expertise in monitoring minority accrual, ClinPortal, CaTissue, REDCap and data management/analysis for clinical studies. Collectively, these individuals have affiliations with both the Washington University School of Medicine and the Siteman Cancer Center. Their SPORE collaborations will be based on areas of expertise. The Biostatistics Core members have participated regularly in planning meetings for SPORE projects, and will participate in design of developmental projects and career development projects. The specific aims of this core are to 1: Provide ready access to statistical expertise and computing consultation to the Pancreatic Cancer SPORE; 2: Provide biostatistical/epidemiological expertise for the planning, analysis and reporting of laboratory experiments, epidemiology studies, and clinical trials and links to the bioinformatics core resources for microarray data and high-throughput genomics data processing as needed; 3: Advise and support SPORE investigators and their data collectors (technicians, nurses, data managers, etc.) in the areas of data form design, data collection, record abstraction, computerization, database designing and management, and data quality control; 4: Provide the scientific computing expertise required to meet the data management and analytical needs of Pancreatic Cancer SPORE investigators, and support interpretation and presentation of data.

项目摘要 生物统计学核心（BC）为所有人提供统计设计，数据管理和计算支持 胰腺癌孢子研究人员。卑诗省将支持有关各个方面的咨询和协作 研究设计，数据库开发和质量控制，以及数据的分析和解释。这 参与生物统计学核心的统计学家已被选为广泛的专业知识和 在临床试验，实验室实验，遗传学和基因组学研究以及流行病学方面的经验 研究。 Graham Colditz博士和Esther Lu博士（以前命名为Jingxia Liu）具有丰富的经验 综合癌症中心环境中的调查人员和统计学家。例如，冯高博士有 与Wang-Gillam博士（项目3上的临床共同领导者）合作，她正在进行的随机控制 化学疗法治疗胰腺癌的临床试验。他们得到了员工的支持 监测少数派应计，临床，搭配，REDCAP和数据管理/分析的专业知识 临床研究。总的来说，这些人都与华盛顿大学学校有隶属关系 医学和现场癌症中心。他们的孢子合作将基于专业领域。 生物统计学核心成员已定期参加孢子项目的计划会议，并将 参与发展项目和职业发展项目的设计。这个核心的具体目的 到1：为胰腺癌提供现成的统计专业知识和计算咨询 孢子; 2：为计划，分析和报告提供生物统计/流行病学专业知识 实验室实验，流行病学研究以及临床试验以及与生物信息学核心资源的联系 对于微阵列数据和高通量基因组学数据处理； 3：建议和支持孢子 研究表格领域的研究人员及其数据收集器（技术人员，护士，数据经理等） 设计，数据收集，记录抽象，计算机化，数据库设计和管理以及数据 质量控制； 4：提供满足数据管理所需的科学计算专业知识 胰腺癌孢子研究者的分析需求，并支持解释和表示 数据。