The University of Iowa's Regional Stroke Research Network

爱荷华大学区域中风研究网络

• 批准号: 9977270
• 负责人: ENRIQUE Carlos LEIRA
• 金额: $ 29.81万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9977270
• 关键词: Academic Medical Centers; Acute; Agreement; American; Aneurysm; Area; Assessment tool; Benchmarking; Businesses; Caring; Cerebrovascular Disorders; Classification; Clinical; Clinical Trials; Communities; Community Hospitals; Consent; Development; Engineering; Enrollment; Epidemiologist; Funding; Geographic Locations; Geography; Goals; Grant; Growth; Hospitals; Infrastructure; Institution; Institutional Review Boards; Intervention; Iowa; Iowan; Leadership; Location; Medicine; Midwestern United States; Mind; Mission; Modernization; Multi-Institutional Clinical Trial; National Institute of Neurological Disorders and Stroke; Nebraska; North Dakota; Operative Surgical Procedures; Outcome; Patient Recruitments; Patient-Focused Outcomes; Patients; Phase; Population; Positioning Attribute; Prevention; Protocols documentation; Recovery; Research; Research Infrastructure; Research Personnel; Research Proposals; Role; Rural; Site; Specialist; Stroke; Stroke prevention; StrokeNet trials; Subarachnoid Hemorrhage; Testing; Time; TimeLine; Training; Training and Education; Translational Research; Trust; United States National Institutes of Health; Universities; Work; acute stroke; bench to bedside; cerebrovascular; college; critical access hospital; health disparity; improved; improved outcome; innovation; multidisciplinary; natural hypothermia; next generation; novel strategies; organizational structure; phase III trial; pragmatic trial; recruit; rural patients; rural underserved; stroke intervention; stroke therapy; stroke trials; translational scientist; working group

The University of Iowa (UI) Regional Stroke Research Network meets the goal of NIH StrokeNet in maximizing efficiencies to develop, promote, and conduct high quality multi-site clinical trials testing promising interventions in stroke prevention, treatment, and recovery. The current proposal builds on the rich tradition of the UI as a leader in both developing and conducting NINDS-sponsored research, The long-term goal of this proposal is to improve the outcomes of the 800,000 Americans who suffer a stroke every year, particularly those subjected to disparities in health outcomes due to geographically underserved areas. Our proposal's immediate goals are to improve the collective network recruitment efficiency and generalizability of NINDS- sponsored trials by facilitating enrollment of subjects with geographical barriers to participation. Specifically, we aim to increase the number of efficient stroke interventions that can be applied to the vast majority of patients in the US. With that goal in mind, we propose to maintain the UIRCC as an Upper Midwest regional research network efficient in recruiting subjects in NINDS- funded stroke trials. The UIRCC is an already operational infrastructure of 14 trial-ready hospitals in Iowa, Nebraska, and North Dakota that enables enrollment of Americans that have been traditionally challenging to include in trials due to their geographically location. At the same time, the UIRCC will continue to engage a multidisciplinary team of translational researchers to generate innovative research proposals that will lead to multicenter clinical trials through StrokeNet.

爱荷华大学（UI）区域中风研究网络实现了NIH Strokenet的目标 为了提高发展，促进和进行高质量多站点临床试验的效率 测试预防中风，治疗和恢复中有希望的干预措施。电流 提案以UI作为发展和进行的领导者的丰富传统为基础 Ninds赞助的研究，该提案的长期目标是改善 每年遭受中风的80万美国人，尤其是那些遇到差异的美国人 由于地理位置不足的地区而导致的健康结果。我们的提议的直接目标 是为了提高Ninds的集体网络招聘效率和概括性 赞助试验通过促进具有地理障碍的受试者的入学率。 具体而言，我们旨在增加可以应用的高效中风干预措施的数量 美国绝大多数患者。考虑到这个目标，我们建议保持 UIRCC作为中西部地区研究网络有效地招募Ninds- 资助中风试验。 UIRCC是已有14个试用的已经运营的基础架构 爱荷华州，内布拉斯加州和北达科他州的医院，使美国人入学 传统上，由于其地理位置上的位置，在试验中都具有挑战性。同样 时间，UIRCC将继续与一个跨学科的翻译研究人员团队联系 生成创新的研究建议，将通过 Strokenet。