The University of Iowa's Statewide Stroke Research Network

爱荷华大学全州中风研究网络

• 批准号: 8739693
• 负责人: ENRIQUE Carlos LEIRA
• 金额: $ 36.22万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8739693
• 关键词: Academic Medical Centers; Address; Advocate; American; Aneurysm; Caring; Cerebrovascular Disorders; Child health care; Classification; Clinic; Clinical; Clinical Investigator; Clinical Services; Clinical Trials; Clinical Trials Design; Collaborations; County; Development; Ensure; Epidemiologist; Equilibrium; Face; Faculty; Funding; Goals; Grant; Health; Health Alliance; Health Personnel; Health Services; Healthcare; Hospital Administrators; Hospitals; Industry; Institution; Iowa; Lead; Link; Medical center; Methods; Modeling; Multi-Institutional Clinical Trial; Nafion; National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; Nebraska; Operative Surgical Procedures; Outcome; Patient Recruitments; Patients; Perinatal; Phase; Phase III Clinical Trials; Physicians; Prevention; Provider; Public Health; Randomized Clinical Trials; Recovery; Research; Research Infrastructure; Research Personnel; Research Proposals; Role; Rural; Rural Community; Site; Staging; Stroke; Stroke prevention; Subarachnoid Hemorrhage; Teaching Hospitals; Testing; Training; Translational Research; Trust; United States National Institutes of Health; Universities; Work; acute stroke; bench to bedside; cost; critical access hospital; data sharing; experience; improved; innovation; interest; meetings; member; natural hypothermia; network models; novel strategies; pragmatic trial; programs; public health relevance; tool

DESCRIPTION (provided by applicant): The University of lowa (Ul) Statewide Stroke Research Network meets the goal of the NINDS Stroke Trials Network of maximizing efficiencies in developing, promoting, and conducting high quality multi-site clinical trials on stroke prevention, treatment, and recovery. The current proposal builds on the rich tradition of the Ul as a leader in both developing and conducting NINDS-sponsored research, as well as on the Ul's role as the hub of a new integrated health care network - The Ul Health Alliance. The long-term goals of this proposal are to improve the efficiency of conducting Phase I - III stroke trials and to ensure a robust pipeline of well-trained clinical investigators to lead such trials. he proposal's immediate goal is to establish an expanded statewide research network for conducting stroke trials that reaches underserved rural patients who currently are unable to participate in stroke trials due to geographical barriers and who are subject to disparities in health outcomes. The proposed University of lowa Regional Coordinating Center (UIRCC) represents a comprehensive and integrated infrastructure for conducting trials that brings together healthcare providers, hospital administrators, clinical and health service investigators, public health officials, and patient advocates. The UIRCC comprises a network that expands the research capabilities of the Ul to 12 trial-ready sites. Those hospitals will be supplied by a statewide infrastructure of spokes that will allow adequate representation in trials of those Americans first evaluated at critical access hospitals. The UIRCC will capitalize on prior work by the PI to improve recruitment of patients presenting to critical access hospitals and maximize geographic access of patients. The feasibility of this approach is supported by the ongoing research data sharing collaboration, and a strong institutional support from the statewide healthcare alliance. We have plans already in place to expand this statewide network model to Nebraska and to the Dakotas. The UIRCC will also develop innovative translational research proposals that will lead to multicenter clinical trials through the NINDS stroke network by bringing together clinicians, early stage (i.e., bench to bedside) translational investigators, clinical trialists, epidemiologists, biostatisticians, and geographers to develop proposals of new approaches to stroke treatment, recovery, and prevention that utilize innovative methods (e.g., adaptive and pragmatic trial designs), and that focuses on the special needs of rural patients. We are particularly interested in trials testing promising therapies to augment recovery after stroke; as such treatments may have a large public health impact.

描述（由申请人提供）：Lowa大学（UL）全州中风研究网络符合Ninds中风试验网络的目标，即在开发，促进和进行高质量的预防，治疗，治疗和康复方面最大程度地提高发展，促进和进行高质量的多站点临床试验。当前的提案以UL作为发展和进行NINDS赞助的研究的领导者以及UL作为新的综合卫生保健网络 - UL Health Alliance的枢纽的角色为基础。该提案的长期目标是提高进行I-III阶段中风试验的效率，并确保训练有素的临床研究人员的强大管道领导此类试验。他提出的近期目标是建立一个扩大的全州研究网络，用于进行中风试验，该试验到达服务不足的农村患者，这些患者目前由于地理障碍而无法参加中风试验，并且遭受健康结果差异。拟议的Lowa区域协调中心（UIRCC）代表了进行试验的全面综合基础设施，将医疗保健提供者，医院管理人员，临床和卫生服务调查人员，公共卫生官员，公共卫生官员和患者提倡汇集在一起​​。 UIRCC包括一个将UL的研究功能扩展到12个试用站点的网络。这些医院将由全州范围内的辐条基础设施提供，这些基础设施将允许在最初在关键访问医院进行评估的美国人的试验中获得足够的代表。 UIRCC将利用PI的先前工作，以改善出现在关键访问医院的患者的招募并最大程度地提高患者的地理访问。这种方法的可行性得到了正在进行的研究数据共享协作的支持，以及全州医疗保健联盟的大力机构支持。我们已经制定了计划，将此全州网络模型扩展到内布拉斯加州和达科他州。 The UIRCC will also develop innovative translational research proposals that will lead to multicenter clinical trials through the NINDS stroke network by bringing together clinicians, early stage (i.e., bench to bedside) translational investigators, clinical trialists, epidemiologists, biostatisticians, and geographers to develop proposals of new approaches to stroke treatment, recovery, and prevention that utilize innovative methods (e.g.,自适应和务实的试验设计），重点是农村患者的特殊需求。我们对试验测试有希望的疗法的试验特别感兴趣，以增加中风后的恢复；由于这种治疗可能会对公共卫生产生巨大影响。