CoPARC: Colorado Pulmonary Alcohol Research Collaborative

CoPARC：科罗拉多州肺酒精研究合作组织

• 批准号: 9926794
• 负责人: ELLEN L BURNHAM
• 金额: $ 70.15万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9926794
• 关键词: Acetaldehyde; Acetylcarnitine; Admission activity; Adult Respiratory Distress Syndrome; Alcohol consumption; Alcohols; Aliquot; Alveolar Macrophages; Area; Biocompatible Materials; Blood; Blood specimen; Bronchoalveolar Lavage Fluid; Bronchoscopy; Burn injury; California; Cannabis; Cells; Chicago; Clinical; Collection; Colorado; Communication; Communities; Critical Illness; Data; Data Set; Development; Economic Burden; Emerging Technologies; Endotoxins; Enrollment; Ensure; Epithelial Cells; Equipment and supply inventories; Erythrocytes; Evaluation; Exhalation; Faculty; Fatty Acids; Fostering; Funding; Generations; Genomics; Geography; Goals; Grant; Growth; Health; Histologic; Host Defense; Host Defense Mechanism; Human; Immune system; Immunity; Immunoglobulins; Inflammatory; Infrastructure; Institution; Intensive Care Units; Knowledge; Lipids; Louisiana; Lung; Lung diseases; Malondialdehyde; Marketing; Mechanical ventilation; Medical center; Mission; Monoclonal Antibody R24; Morbidity - disease rate; Nasal Epithelium; National Heart, Lung, and Blood Institute; National Institute on Alcohol Abuse and Alcoholism; Nebraska; Needs Assessment; Online Systems; Oropharyngeal; Outcome; Oxidative Stress; Pathology; Patient-Focused Outcomes; Patients; Peripheral Blood Mononuclear Cell; Phospholipids; Plasma; Pneumonia; Production; Proteins; Publications; Recording of previous events; Research; Research Personnel; Research Subjects; Resources; Respiratory Failure; Respiratory System; Risk; Risk Factors; San Francisco; Site; Smoker; Specimen; Strategic Planning; Streptococcus pneumoniae; System; Targeted Research; Taxonomy; Therapeutic Intervention; Time; Tissues; Translational Research; Universities; Urine; adduct; airway epithelium; alcohol effect; alcohol research; alcohol use disorder; antimicrobial peptide; base; biomarker development; burden of illness; career development; clinical material; cytokine; data sharing; genome sequencing; improved; innovation; lung microbiome; marijuana use; microbiome alteration; microbiota; mortality; novel; pathogen; prevent; prophylactic; racial diversity; receptor expression; response; whole genome

Project Summary The goal of this proposal is to seek continued support to augment and sustain an established Alcohol Research Resource, known as CoPARC (Colorado Pulmonary-Alcohol Research Collaborative). CoPARC's mission is to facilitate research that will prevent the development of alcohol-associated pneumonia, ameliorate its deleterious complications, and ultimately improve clinical outcomes. Alcohol use disorders (AUDs) confer an eight-fold increased risk for community-acquired pneumonia. AUDs also increase morbidity for patients with pneumonia, including increasing the risk of respiratory failure necessitating intensive care unit (ICU) admission and mechanical ventilation. Further, AUD-associated pneumonia is frequently complicated by the development of the acute respiratory distress syndrome (ARDS). Centered at the University of Colorado Denver (UCD) and led by Ellen L. Burnham, MD, MS, the CoPARC infrastructure has enabled enrollment of over 370 ambulatory subjects with and without AUDs, and 237 critically ill patients with pneumonia or burn injury, established ARDS risk factors that are more prevalent in patients with AUDs. Resource materials have originated from institutions with a history of NIAAA-funded translational research in alcohol-related pulmonary diseases, including UCD, Emory University (EU), and Loyola University Chicago (LUC); and from the University of California San Francisco (UCSF) with NHLBI support. Presently, thousands of biospecimens have been collected, including bronchoalveolar lavage (BAL) fluid and cell aliquots; bronchial brushings; and blood specimens. To date, 26 investigators from 11 external institutions have utilized over 6100 biospecimens from 92% of the enrolled subjects. For the renewal, 4 sites (EU, LUC, UCSF, and the University of Nebraska Medical Center) and UCD will collect materials for CoPARC. A Steering Committee comprised of investigators from UCD, EU, LUC, Louisiana State University, UNMC, and Thomas Jefferson University will provide rigorous oversight for CoPARC, including prioritization of biospecimen distribution, and ensuring that milestones promoting use of the Resource are achieved. Innovations that are planned include collection of novel specimens such as whole lung explants; expertise in high-throughput genomics applications; access to administrative data sets enriched in patients with alcohol use; and organization of clinical, inventory, and experimental data to foster cross- investigator sharing. Aims for the renewal are in line with the NIAAA's strategic plan to identify mechanisms of alcohol action and alcohol-related pathology to more fully understand how alcohol asserts its effects on human health. They include: 1) expand and diversify clinical and biological materials obtained from ambulatory subjects with AUDs and critically ill patients, along with appropriate controls, 2) engage emerging web-based systems to prioritize data and biospecimen sharing, and streamline communications between investigators as well as the Steering Committee and 3) enhance visibility and marketing to promote the distribution, growth, and sustainability of the Resource.

项目摘要 该提案的目的是寻求持续的支持以增加和维持既定的酒精 研究资源，称为COPARC（科罗拉多州肺泡研究合作）。 COPARC的 使命是促进研究，以防止与酒精相关的肺炎发展，改善 它的有害并发症，并最终改善临床结果。酒精使用障碍（AUDS）授予 社区获得性肺炎的风险增加了八倍。 AUDS还增加了患者的发病率 肺炎，包括增加需要重症监护病房（ICU）入院的呼吸衰竭风险 和机械通风。此外，与声音相关的肺炎经常因发育而变得复杂 急性呼吸窘迫综合征（ARDS）的集中于科罗拉多大学丹佛分校（UCD）和 由医学博士Ellen L. Burnham领导，Coparc基础设施已使370多个非卧床入学 有或没有AUD的受试者，以及237例肺炎或烧伤的患者，已建立的ARDS 在AUD患者中更普遍的危险因素。资源材料起源于机构 拥有NIAAA资助的与酒精相关肺部疾病的转化研究史，包括UCD， 埃默里大学（EU）和洛约拉大学芝加哥（LUC）；来自加利福尼亚大学圣 Francisco（UCSF）具有NHLBI支持。目前，已经收集了成千上万的生物测量 支气管肺泡灌洗（BAL）流体和细胞等分试样；支气管刷；和血液标本。迄今为止，26 来自11个外部机构的调查人员已经使用了92％ 主题。对于续订，有4个站点（欧盟，卢克，UCSF和内布拉斯加州大学医学中心）和UCD 将收集Coparc的材料。指导委员会由UCD，欧盟，卢克的调查人员组成， 路易斯安那州立大学，UNMC和托马斯·杰斐逊大学将为严格的监督 COPARC，包括生物测量分布的优先级，并确保促进使用的里程碑 实现了资源。计划的创新包括收集新颖标本，例如整个肺 epplants;高通量基因组应用的专业知识；访问丰富的管理数据集 饮酒的患者；以及临床，库存和实验数据的组织，以促进跨 调查员分享。续签的目标与NIAAA的战略计划一致，以确定 酒精作用和与酒精有关的病理，以更充分了解酒精如何主张其对人的影响 健康。其中包括：1）扩展和多样化从非卧床获得的临床和生物材料 具有澳元和重症患者的受试者以及适当的对照，2）与新兴的基于Web 确定数据和生物测量共享的系统，并简化调查人员之间的通信 以及指导委员会和3）增强可见性和营销，以促进分布，增长和 资源的可持续性。