Numbers in the Human Brain

人脑中的数字

基本信息

批准号：
9927687
负责人：
Josef Parvizi
金额：
$ 39.5万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-01 至 2021-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9927687
关键词：
Address Affect Anatomy Architecture Area Arithmetic Arts Attention Behavior Behavioral Biological Process Brain Categories Chronic Civilization Code Cognition Cognitive Education Electrical Stimulation of the Brain Electrocorticogram Electrodes Electrophysiology (science)Evoked Potentials Exhibits Experimental Models Frequencies Future Goals Human Human body Implant Individual Inferior Knowledge Language Lateral Learning Link Literature Location Maps Mathematics Measures Memory Molds Monitor Nature Neurons Neurosciences Research Parietal Phase Population Positioning Attribute Process Property Reaction Time Reading Research Rest Role Semantics Services Signal Transduction Site Societies Surface Surrogate Markers Temporal Lobe Therapeutic Thinking Time Visual Visual Perception Visual system structure Work behavior change behavior measurement behavioral response cognitive function experience fascinate functional plasticity human subject insight intraparietal sulcus invention millimeter millisecond multimodality neuroregulation nonhuman primate novel prototype public health relevance response spatiotemporal temporal measurement visual processing

项目摘要

DESCRIPTION (provided by applicant): Human civilizations are hallmarked by communicating magnitude, time, and space in the form of numeral symbols. Humans learn to speak a certain language and read its symbols depending on the culture they live in. All brains are known to have specialized group of neuronal populations in the visual system that, through education and culture, are pruned to recognize these visual symbols, and be able to feed them to specific networks of the brain where they are processed. The existence of neuronal populations in the brain's visual system to respond selectively to numerals is a fascinating example of how nurture affects our nature, i.e., how cultural experience and education change the brain's biological function. Yet, relatively little is known about the way these specialized populations of neurons operate in the visual system and with the networks of language and numerosity. The proposed work will be the first multimodal approach to combine direct recordings from the surface of the human brain (electrocorticography, ECoG) as well as causing reversible functional perturbations by electrical brain stimulation (EBS). The proposed work aims to provide a comprehensive map of the location and functional properties and connectivity of the specialized areas of the ventral temporal cortex (VTC) for numerals (i.e., visual numeral area (VNA). Lastly, we propose to study how the neuronal population activities change in the VTC when human subjects learn to associate foreign symbols with their categorical and semantic identities. We are hopeful and confident that our novel multimodal approach will provide unprecedented spatiotemporal information to clarify the outstanding questions about the functional contributions of VTC subregions to how numbers are processed in the human brain.

描述（由应用程序提供）：人类文明以数字符号的形式传达幅度，时间和空间标志性。人类学会说某种语言，并根据他们所生活的文化阅读其符号。众所周知，所有大脑都在视觉系统中具有专门的神经元种群，通过教育和文化，它们可以修剪来识别这些视觉符号，并能够将它们喂给它们处理的大脑特定网络。大脑视觉系统中神经元种群的存在以选择性地响应众多病例，这是护士如何影响我们本性的一个令人着迷的例子，即文化经验和教育如何改变大脑的生物学功能。然而，对于这些在视觉系统中运行的神经元以及语言和数字性网络中运行的神经元的专业人群的了解，相对较少。拟议的工作将是第一种组合人脑表面直接记录的多模式方法（电代理，ECOG），并通过电脑刺激（EBS）引起可逆的功能扰动。拟议的工作旨在提供数值的腹侧临时皮层（VTC）的位置和功能特性的全面图（即视觉数字区域（VNA）（VNA）。最后，我们建议我们研究当人类在人类中与他们的类别构成的互联性符号和识别性的群体时，我们的神经元种群活动如何变化，并与我们的符号保持一致。将提供前所未有的时空信息，以阐明有关VTC子区域对人类大脑中数字如何处理的功能贡献的杰出问题。