A Smartphone-Based Device for Cuff-Less and Calibration-Free Blood Pressure Monitoring

基于智能手机的无袖带、免校准血压监测设备

• 批准号: 9927703
• 负责人: RAMAKRISHNA MUKKAMALA
• 金额: $ 33.49万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-15 至 2020-05-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9927703
• 关键词: Achievement; Algorithms; Area; Arteries; Attention; Auscultation; Awareness; Blood Pressure; Blood Pressure Monitors; Blood Volume; Calibration; Cardiovascular system; Caregivers; Cellular Phone; Data Set; Devices; Feedback; Fingers; Goals; Heart; Hypertension; Incidence; Investigation; Location; Measurement; Measures; Medical; Methods; Myocardial Infarction; Optics; Oscillometry; Output; Paper; Patients; Pharmaceutical Preparations; Photoplethysmography; Population; Positioning Attribute; Protocols documentation; Publishing; Research; Risk Factors; Secure; Stroke; System; Technology; Telephone; Testing; Text; Time; Training; Transducers; Translating; Translational Research; base; cardiovascular risk factor; cohort; force sensor; hypertension control; image processing; improved; individual patient; instrumentation; monitoring device; mortality; physiologic model; pressure; prospective test; sensor; translational medicine; visual feedback

PROJECT SUMMARY/ABSTRACT High blood pressure (BP) is a major cardiovascular risk factor that is treatable, yet hypertension awareness and control rates are low. Ubiquitous BP monitoring technology could improve hypertension management, but existing devices require an inflatable cuff and thus do not afford anytime, anywhere measurement of BP. The broad goal of this project is to extend the oscillometric principle, which is applied by most automatic cuff devices, for cuff-less and calibration-free monitoring of BP via only a smartphone. The idea is for the user to serve as the actuator (instead of the cuff) by pressing her fingertip against the phone to steadily increase the external pressure of the underlying artery, while the phone serves as the sensor (rather than the cuff) by measuring the applied pressure and resulting variable-amplitude blood volume oscillations. The phone also provides visual feedback to guide the finger actuation and applies an algorithm to compute BP from the measurements just like a cuff. A smartphone-based device for BP monitoring via this oscillometric finger pressing method will be established. The specific aims are: (1) to develop an advanced sensor-unit to robustly measure the finger blood volume and applied finger pressure; (2) to develop an advanced algorithm to accurately compute BP from the measurements in a diverse user population; and (3) to validate the integrated device according to a widely accepted protocol. An initial device will be developed to acquire a comprehensive set of potentially useful measurements including the pulsatile component of the finger pressure arising from the tonometric principle. This device will consist of a multi- photoplethysmography sensor array to identify the location of the finger artery and measure the blood volume oscillations from therein and a multi-force sensor array to measure the area of force application. The advanced sensor-unit will mitigate the impact of imprecise finger positioning. A training dataset will be collected with this device and cuff-based devices in a diverse user population. This dataset will be analyzed to develop an algorithm to accurately compute BP. The algorithm will include leveraging the smartphone camera and image processing to obtain the BP measurement at heart level and computing finger and brachial systolic, diastolic, and mean BP based on various physiologic models of the measurements. A final smartphone-based device will be built that incorporates the requisite sensing and algorithm. The device will be prospectively tested according to the standard Association for the Advancement of Medical Instrumentation protocol for automatic cuff devices. This protocol includes 85 subjects encompassing a wide BP range with auscultation cuff BP as the reference. Successful completion of this project could ultimately translate to widespread BP monitoring and thereby help reduce the incidence of cardiovascular mortality.

项目摘要/摘要 高血压（BP）是可治疗但高血压的主要心血管危险因素 意识和控制率很低。无处不在的BP监测技术可以改善 高血压管理，但现有设备需要充气袖口，因此无负担 随时随地，BP的测量值。该项目的广泛目标是扩展振荡 原理是由大多数自动袖口设备应用的，用于无袖带和无校准的监视 BP仅通过智能手机。这个想法是让用户通过 将她的指尖按在手机上，以稳步增加底层的外部压力 动脉，手机通过测量施加的压力来充当传感器（而不是袖口） 并产生的可变振幅血容量振荡。手机还提供视觉反馈 指导手指驱动并应用算法以从测量中计算BP 袖口。通过这种振荡指标按压方法，用于BP监视的基于智能手机的设备 将建立。具体目的是：（1）开发一个高级传感器单元以稳健 测量手指血容量并施加的手指压力； （2）开发高级算法 从多样化的用户群体中的测量中准确计算BP； （3）验证 根据广泛接受的协议进行集成设备。初始设备将被开发为 获得一组全面有用的测量值，包括 the骨原理产生的手指压力。该设备将由多个 光杀解物学传感器阵列以识别手指动脉的位置并测量血液 其中的体积振荡和多力传感器阵列以测量力区域 应用。高级传感器单元将减轻不精确的指位置的影响。一个 培训数据集将使用该设备和基于袖口的设备收集到不同的用户群体中。 该数据集将进行分析以开发一种算法以准确计算BP。该算法将 包括利用智能手机摄像头和图像处理以获得BP测量 基于各种 测量的生理模型。将建造最终的基于智能手机的设备 结合必要的传感和算法。该设备将根据 自动袖口医学仪器协议的标准协会 设备。该协议包括85个主题，其中包括带有听觉袖口BP的宽BP范围 作为参考。该项目的成功完成可能最终转化为广泛的BP 监测，从而有助于降低心血管死亡率的发生率。