Neural Correlates of Reward and Symptom Expression in Anorexia Nervosa

神经性厌食症奖赏与症状表达的神经相关性

• 批准号: 9925290
• 负责人: Ann Frances Haynos
• 金额: $ 18.23万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-02 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9925290
• 关键词: Address; Adult; Affect; Aftercare; Anorexia Nervosa; Biological; Biometry; Calories; Characteristics; Clip; Crows; Cues; Decision Making; Development; Diagnostic; Disease; Disease remission; Eating Disorders; Energy Intake; Family; Fatty acid glycerol esters; Food; Food Selections; Functional Magnetic Resonance Imaging; Funding; Goals; Healthcare Systems; Hospitalization; Individual; Inpatients; Intake; Intervention; Knowledge; Laboratories; Maintenance; Measures; Mentors; Mentorship; Methodology; Modeling; Neurobiology; Outcome; Outcomes Research; Pathology; Patient Self-Report; Positioning Attribute; Process; Psychological reinforcement; Psychopathology; Psychopharmacology; Psychotherapy; Recovery; Relapse; Research; Research Design; Research Personnel; Rewards; Risk; Societies; Stimulus; Symptoms; Testing; To specify; Training; Translating; Weight; burden of illness; comorbidity; cost; disorder control; longitudinal analysis; longitudinal design; mortality; neural correlate; neural patterning; neuroimaging; neuroregulation; novel; predicting response; psychobiologic; psychologic; relapse prediction; relapse risk; response; restrictive eating; reward circuitry; skills; social; theories; weight restoration

PROJECT SUMMARY/ABSTRACT This K23 application aims to support Dr. Ann Haynos her overarching goal of becoming an independent researcher focused on: (a) identifying biological and psychological mechanisms of disordered eating and (b) using this information to inform the development of novel and targeted treatments for eating disorders. The proposed application will strengthen the candidate's abilities to meet these goals by providing advanced training to: (a) develop expertise in theory and assessment of reward mechanisms involved in the cross- diagnostic psychopathology, and to translate this knowledge to research for eating disorders; (b) gain knowledge and skills in neuroimaging necessary to conduct independent research investigating neurobiological underpinnings of disordered eating; and (c) obtain expertise in longitudinal design, methodology, and analysis needed to conduct research examining maintenance of disordered eating. To achieve these goals, an expert team of mentors has been assembled, consisting of primary mentor, Dr. Scott Crow (for training in translational eating disorder research and longitudinal methodology), co-mentors, Dr. Jazmin Camcong (for training in cross-diagnostic reward models), Dr. Kelvin Lim (for training in neuroimaging) and Dr. James Hodges (for training in biostatistics and longitudinal analyses), as well as consultants Dr. Angus MacDonald, III, and Dr. Joanna Steinglass (for training in specific reward and decision-making tasks). As part of this training, Dr. Haynos will complete a project that will identify responses in mesolimbic reward circuitry to typically rewarding stimuli (i.e., entertaining video clips) and disorder-specific stimuli (i.e., restrictive eating cues) among recently weight restored individuals with anorexia nervosa (AN). This study will determine whether responding in mesolimbic circuitry to typical and/or disorder-specific rewards predicts restrictive eating and risk of relapse. AN is associated with extremely poor outcomes and high mortality rates. Although intensive treatment can restore weight to a healthy range, half of individuals with AN relapse within one year of weight restoration. These poor outcomes are due, in part, to the excessive drive towards restrictive eating characterizing this disorder. Little is known regarding the psychobiological mechanisms that maintain restrictive eating and promote relapse. However, there is initial research suggesting that deficit valuation of typically rewarding cues and enhanced valuation of disorder-specific rewards may influence AN symptoms. Therefore, in addition to assisting towards the candidate's training goals, this project will meet a critical need by identifying reward mechanisms predicting restrictive eating and relapse in AN. This knowledge will ultimately promote the development of more effectively targeted treatments promoting long-term recovery from AN.

项目概要/摘要 此 K23 申请旨在支持 Ann Haynos 博士成为独立的总体目标 研究人员专注于：(a) 确定饮食失调的生物和心理机制；(b) 利用这些信息为饮食失调的新颖和有针对性的治疗方法的开发提供信息。这 拟议的申请将通过提供先进的技术来增强候选人实现这些目标的能力 培训目的是：(a) 发展跨领域奖励机制的理论和评估方面的专业知识 诊断精神病理学，并将这些知识转化为饮食失调的研究； (b) 增益 进行神经生物学独立研究所需的神经影像知识和技能 饮食失调的基础； (c) 获得纵向设计、方法和分析方面的专业知识 需要进行研究来检查饮食失调的维持情况。为了实现这些目标，专家 导师团队已经组建完毕，其中包括主要导师 Scott Crow 博士（用于转化培训） 饮食失调研究和纵向方法），共同导师 Jazmin Camcong 博士（接受培训 交叉诊断奖励模型）、Kelvin Lim 博士（神经影像学培训）和 James Hodges 博士（ 生物统计学和纵向分析培训），以及顾问 Angus MacDonald, III 博士和 Dr. Angus MacDonald, III。 Joanna Steinglass（针对特定奖励和决策任务的培训）。 作为本次培训的一部分，海诺斯博士将完成一个项目，该项目将确定中脑边缘奖励的反应 通常奖励刺激（即娱乐性视频剪辑）和特定于疾病的刺激（即限制性刺激）的电路 最近体重恢复的神经性厌食症（AN）患者中的饮食线索）。这项研究将确定 中脑边缘回路对典型和/或疾病特异性奖励的反应是否预示着限制性饮食 和复发的风险。 AN 与极差的结果和高死亡率相关。虽然 强化治疗可以将体重恢复到健康范围，一半的 AN 患者在一年内复发 体重恢复。这些不良结果的部分原因是过度限制饮食 描述这种疾病的特征。关于维持限制性的心理生物学机制知之甚少 饮食并促进复发。然而，初步研究表明，赤字估值通常 奖励线索和对特定疾病奖励的增强评估可能会影响 AN 症状。所以， 除了协助候选人实现培训目标外，该项目还将通过确定 奖励机制预测 AN 中的限制性饮食和复发。这些知识最终将促进 开发更有效的靶向治疗方法，促进 AN 的长期康复。