Neural Correlates of Reward and Symptom Expression in Anorexia Nervosa

神经性厌食症奖赏与症状表达的神经相关性

• 批准号: 10210205
• 负责人: Ann Frances Haynos
• 金额: $ 14.4万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-02 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10210205
• 关键词: Address; Adult; Affect; Aftercare; Anorexia Nervosa; Biological; Biometry; Calories; Characteristics; Clip; Crows; Cues; Decision Making; Development; Diagnostic; Disease; Disease remission; Eating Disorders; Energy Intake; Family; Fatty acid glycerol esters; Food; Food Selections; Functional Magnetic Resonance Imaging; Funding; Goals; Healthcare Systems; Hospitalization; Individual; Inpatients; Intake; Intervention; Knowledge; Laboratories; Maintenance; Measures; Mentors; Mentorship; Methodology; Modeling; Neurobiology; Outcome; Outcomes Research; Pathology; Patient Self-Report; Positioning Attribute; Process; Psychological reinforcement; Psychopathology; Psychopharmacology; Psychotherapy; Recovery; Relapse; Research; Research Design; Research Personnel; Rewards; Risk; Societies; Stimulus; Symptoms; Testing; To specify; Training; Translating; Weight; burden of illness; comorbidity; cost; disorder control; longitudinal analysis; longitudinal design; mortality; neural correlate; neural patterning; neuroimaging; neuroregulation; novel; predicting response; psychobiologic; psychologic; relapse prediction; relapse risk; response; restrictive eating; reward circuitry; skills; social; theories; weight restoration

PROJECT SUMMARY/ABSTRACT This K23 application aims to support Dr. Ann Haynos her overarching goal of becoming an independent researcher focused on: (a) identifying biological and psychological mechanisms of disordered eating and (b) using this information to inform the development of novel and targeted treatments for eating disorders. The proposed application will strengthen the candidate's abilities to meet these goals by providing advanced training to: (a) develop expertise in theory and assessment of reward mechanisms involved in the cross- diagnostic psychopathology, and to translate this knowledge to research for eating disorders; (b) gain knowledge and skills in neuroimaging necessary to conduct independent research investigating neurobiological underpinnings of disordered eating; and (c) obtain expertise in longitudinal design, methodology, and analysis needed to conduct research examining maintenance of disordered eating. To achieve these goals, an expert team of mentors has been assembled, consisting of primary mentor, Dr. Scott Crow (for training in translational eating disorder research and longitudinal methodology), co-mentors, Dr. Jazmin Camcong (for training in cross-diagnostic reward models), Dr. Kelvin Lim (for training in neuroimaging) and Dr. James Hodges (for training in biostatistics and longitudinal analyses), as well as consultants Dr. Angus MacDonald, III, and Dr. Joanna Steinglass (for training in specific reward and decision-making tasks). As part of this training, Dr. Haynos will complete a project that will identify responses in mesolimbic reward circuitry to typically rewarding stimuli (i.e., entertaining video clips) and disorder-specific stimuli (i.e., restrictive eating cues) among recently weight restored individuals with anorexia nervosa (AN). This study will determine whether responding in mesolimbic circuitry to typical and/or disorder-specific rewards predicts restrictive eating and risk of relapse. AN is associated with extremely poor outcomes and high mortality rates. Although intensive treatment can restore weight to a healthy range, half of individuals with AN relapse within one year of weight restoration. These poor outcomes are due, in part, to the excessive drive towards restrictive eating characterizing this disorder. Little is known regarding the psychobiological mechanisms that maintain restrictive eating and promote relapse. However, there is initial research suggesting that deficit valuation of typically rewarding cues and enhanced valuation of disorder-specific rewards may influence AN symptoms. Therefore, in addition to assisting towards the candidate's training goals, this project will meet a critical need by identifying reward mechanisms predicting restrictive eating and relapse in AN. This knowledge will ultimately promote the development of more effectively targeted treatments promoting long-term recovery from AN.

项目摘要/摘要 该K23应用程序旨在支持Ann Haynos博士成为独立的总体目标 研究人员的重点是：（a）识别饮食无序的生物学和心理机制，（b） 使用此信息为开发新颖和有针对性的饮食疗法。这 拟议的申请将通过提供先进的能力来增强候选人实现这些目标的能力 培训：（a）在理论和评估涉及的奖励机制方面发展专业知识 诊断心理病理学，并将这些知识转化为饮食失调的研究； （b）增益 进行神经生物学的独立研究所需的神经影像学知识和技能 饮食失调的基础； （c）获得纵向设计，方法和分析方面的专业知识 需要进行研究，以检查无序饮食的维持。为了实现这些目标，专家 导师团队已经组装，包括主要导师斯科特·克劳（Scott Crow）博士（用于翻译的培训 饮食障碍研究和纵向方法论），联合会员Jazmin Camcong博士（用于培训 跨诊断奖励模型），Kelvin Lim博士（用于神经影像学培训）和James Hodges博士（用于 生物统计学和纵向分析的培训）以及顾问Angus Macdonald，III和Dr. Joanna Steinglass（用于特定奖励和决策任务的培训）。 作为这项培训的一部分，Haynos博士将完成一个项目，该项目将确定中唇奖励的回答 通常奖励刺激（即娱乐视频剪辑）和特定障碍刺激（即限制性的）电路 饮食提示）最近体重恢复了神经性厌食症的人（AN）。这项研究将确定 在中边缘电路中响应典型和/或特定疾病的奖励是否可以预测限制性饮食 和复发的风险。一个与极差的结果和高死亡率有关。虽然 强化治疗可以使体重恢复到健康范围，其中一半的人在一年内复发 体重恢复。这些不良的结果部分归因于限制性饮食的过度动力 表征这种疾病。关于维持限制性的心理生物学机制知之甚少 进食并促进复发。但是，有最初的研究表明，赤字估值通常 奖励提示和提高疾病特异性奖励的估值可能会影响症状。所以， 除了协助候选人的培训目标外，该项目还将通过识别来满足关键需求 奖励机制可以预测AN的限制性饮食和复发。这些知识最终将促进 开发更有效的针对性治疗方法，促进了An的长期恢复。

项目成果

Education, dissemination, and the science of eating disorders: Reflections on the 2019 International Conference on Eating Disorders: Editorial to accompany IJED Virtual Issue in honor of the 2019 International Conference on Eating Disorders.

饮食失调的教育、传播和科学：对 2019 年饮食失调国际会议的思考：为纪念 2019 年饮食失调国际会议而发布的 IJED 虚拟期刊社论。

• DOI: 10.1002/eat.23050
• 发表时间: 2019
• 期刊: The International journal of eating disorders
• 作者: Forbush,KelsieT;Crosby,RossD;Coniglio,Kathryn;Haynos,AnnF
• 通讯作者: Haynos,AnnF

Which Brief Is Best? Clarifying the Use of Three Brief Versions of the Difficulties in Emotion Regulation Scale.

• DOI: 10.1007/s10862-019-09736-z
• 发表时间: 2019-09-15
• 期刊: Journal of psychopathology and behavioral assessment
• 影响因子: 1.6
• 作者: Skutch JM;Wang SB;Buqo T;Haynos AF;Papa A
• 通讯作者: Papa A

Brief report: Differences in nonsuicidal self-injury according to binge eating and purging status in an adolescent sample seeking eating disorder treatment.

• DOI: 10.1016/j.eatbeh.2020.101389
• 发表时间: 2020-04
• 期刊: EATING BEHAVIORS
• 影响因子: 2.8
• 作者: Dzombak, Jesse W. P.;Haynos, Ann F.;Rienecke, Renee D.;Van Huysse, Jessica L.
• 通讯作者: Van Huysse, Jessica L.