Origin of Chronic Diseases of Aging Among Rural African American Young Adults

农村非裔美国年轻人慢性衰老疾病的起源

• 批准号: 9925262
• 负责人: Gene H. Brody
• 金额: $ 16.82万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-20 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9925262
• 关键词: Acceleration; Address; Adolescence; Adolescent; Adoption; Adult; African American; Age; Aging; Attention; Biological; Biological Aging; Biological Markers; Blood; Buffers; Cardiovascular Diseases; Childhood; Chronic Disease; Chronology; Communities; Complement; Data; Data Collection; Data Set; Deceleration; Development; Disadvantaged; Discrimination; Education; Environment; Epidemic; Epigenetic Process; Exposure to; Family; Foundations; Funding; Future; Generations; Genetic; Glycosylated hemoglobin A; Goals; Health; Health Promotion; Individual Differences; Inflammation; Inflammatory; Investigation; Life Cycle Stages; Life Experience; Link; Literature; Maintenance; Measures; Mediating; Mediation; Metabolic; Metabolic Marker; Metabolic syndrome; National Institute of Child Health and Human Development; Non-Insulin-Dependent Diabetes Mellitus; Occupations; Outcome; Participant; Personal Satisfaction; Physiological; Play; Population; Positioning Attribute; Prevention; Prevention program; Preventive Intervention; Process; Protocols documentation; Public Health; Race; Request for Proposals; Research; Respondent; Risk; Risk Factors; Role; Rural; Sampling; Services; Source; Stress; Testing; Time; Tissues; Triglycerides; Uncertainty; Vulnerable Populations; Wages; Weather; Work; Youth; coping; cost; design; early experience; early onset; emerging adult; experience; health disparity; heuristics; high risk; indexing; insight; novel strategies; peer; prevent; prospective; protective factors; psychosocial; racial discrimination; racial identity; resilience; rural African American; social; social relationships; stem; stressor; theories; therapy design; young adult

PROJECT SUMMARY The current proposal builds upon an ongoing investigation to test hypotheses about (1) the role of psychosocial stressors in “weathering” young bodies, (2) the protective factors that may mitigate their adverse impact, and (3) the role of continuity and change in weathering during a key life course transition. Tests of these hypotheses will enable a better understanding of the role of weathering in forecasting chronic diseases of aging (CDAs) among rural African Americans and set the stage for prevention programming for this vulnerable population. Using recently-developed, direct measures of biological weathering we have found that, by age 20, some SHAPE youth are already experiencing accelerated aging due to psychosocial context. The transition to adulthood provides an opportunity to examine the impact of both new and continuing sources of risk and resilience on weathering and ultimately on CDA vulnerability during this important transition period, allowing us to closely examine the potential for adverse and protective experiences to “bend” the risk curve for future CDAs and so illuminate key targets for preventive intervention. Here, we request funds to supplement the SHAPE study by using blood from an ongoing NICHD-sponsored data collection protocol to characterize each participant's “epigenetic clock” at age 26, providing a key window on weathering and changes in weathering and so allow us to conduct enhanced tests of theory and to more accurately identify high value targets for preventive intervention. By adding this assessment we will have a data set with measures of biological weathering at age 20 and age 26, along with a full complement of indicators of metabolic syndrome, a precursor to type 2 diabetes and cardiovascular disease. This assessment will place no additional burden on SHAPE participants and will substantially increase the public health value of the data set. First, we will examine the impact of exposure to multidimensional SES- and race-related stressors during the transition to adulthood on changes in biological weathering. We expect exposure to stressors, particularly racial discrimination, to play a key role in maintaining or accelerating weathering processes across young adulthood and to presage CDA vulnerability (i.e. metabolic risk and inflammation). Second, we will identify positive, protective influences, both inside and outside the family, that help shift African American young adults off the above-mentioned trajectory to CDAs. We anticipate that these factors will be especially important for young adults who enter the transition to adulthood with already-accelerated weathering. The results of the proposed study will inform the development of preventive interventions designed to slow biological weathering and promote health for a population at high risk for early development of CDAs. By examining not only risk factors for accelerated aging but also protective environments and coping processes that presage a deceleration of biological aging across young adulthood, we will have the necessary ingredients for a new generation of prevention programs designed specifically to deter weathering and promote the health and well-being of rural African Americans, thereby addressing well-documented health disparities.

项目摘要 当前的提案建立在正在进行的投资基础上，以测试有关（1）作用的假设 在“风化”年​​轻身体中的社会心理压力源，（2）可能减轻其不利的保护因素 （3）在关键的生命过程中，连续性和风化的作用 这些假设将更好地理解OLE OLE OLE预测的慢性疾病 农村非洲人的衰老（CDA），为此奠定了舞台 脆弱的人口。 到20岁时，由于心理社会内容而导致的年轻人经历了加速衰老 过渡到成年，证明了统一的统一性，以研究新的和持续来源的影响 在这个重要过渡期间，风险和韧性在风化以及最终在CDA脆弱性上， 允许我们密切检查广告和保护体验的潜力，以“弯曲”风险曲线的forfor 未来的CDA，并阐明了预防干预的关键目标。 通过使用ongod赞助的数据收集方案中的血液来表征形状研究 每个参与者在26岁时的“表观遗传钟”，为风化和变化提供了一个关键窗口 风化，因此让我们能够遏制理论的测试，以至于更多。 预防干预的目标。 20岁和26岁的生物风化，以及代谢综合征指标的全部概念， 2型糖尿病和心血管疾病的先驱。 塑造参与者，并大大提高数据集的公共健康价值。 检查在过渡到多维SES和种族相关的压力源的影响 在生物风化的变化上，我们希望暴露于压力源，尤其是种族 歧视，在维持或加速年轻的风化过程中发挥关键作用 并预示CDA脆弱性（即代谢风险和炎症）。 在家庭内外，保护性影响有助于将非洲裔美国人 @ @成人转移 上述轨迹对CDA的轨迹。 成年人以已融合的风化而进入成年。 研究将为旨在减缓生物学风化和的预防干预措施的发展提供信息 通过检查风险因素，为早期发展的人群促进健康。 用于加速衰老，以及预示减速的保护环境和应对过程 整个成年期的生物年龄，我们将拥有新一代的必要成分 专门旨在阻止风化和促进健康和福祉的乡村的预防计划 非洲裔美国人，从而解决了有据可查的健康差异。