Collaborative Human Tissue Network (CHTN)

协作人体组织网络 (CHTN)

基本信息

批准号：
8669419
负责人：
NILSA DEL CARMEN RAMIREZ MILAN
金额：
$ 79.02万
依托单位：
RESEARCH INST NATIONWIDE CHILDREN'S HOSP
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-11 至 2019-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8669419
关键词：
Adolescent Adult Adverse effects Basic Science Benign Biological Cause of Death Child Childhood Children&apos s Oncology Group Chronic Disease Clinical Clinical Research Clinical Treatment Clinical Trials Collection Communities Conduct Clinical Trials Data Diagnosis Disease Enrollment Ensure Feedback Fostering Genetic Guidelines Health Human Improve Access Informed Consent Malignant - descriptor Malignant Childhood Neoplasm Malignant Neoplasms Mission Molecular Molecular Biology Outcome Pathology Pediatric Hospitals Pediatric Neoplasm Play Preparation Procedures Process Quality Control Research Research Institute Research Personnel Resources Role Specimen Study models Technology Tissues Translational Research Treatment outcome United States Work cancer diagnosis human tissue improved innovation leukemia population based racial and ethnic satisfaction success treatment trial

项目摘要

DESCRIPTION (provided by applicant): The Biopathology Center seeks to foster improvements in the diagnosis and treatment of chronic diseases and cancer, with the ultimate aim of increased cure rates and fewer treatment side effects. Consistent with this mission, the Pediatric Biospecimen Division's broad and long-term objective is to continue our focused efforts to provide scientifically-relevant biospecimens to the research community, including improved access to high-quality pediatric and adolescent human malignant, benign, diseased and uninvolved biospecimens. The pCHTN seeks to directly promote and support outstanding research in the diagnosis and treatment of chronic disease and cancer by pursuing the following specific aims: 1. To make high-quality, scientifically-relevant biospecimens available to the investigator community through continued efforts and innovations in standardized collection, quality control, storage, and biospecimen distribution under proper regulatory guidelines 2. To support translational aspects of cutting-edge research by ensuring appropriate tracking of biospecimen lineage/processing/storage as well as linkages to existing demographic, clinical, biological, treatment, and outcome data 3. To maximize scientific return on limited resources by promoting networking of rare specimens (e.g., leukemia, adolescent cancers) as well as initiating new informed consent procedures to facilitate linkage to clinical outcomes 4. To leverage innovations in technology, best practices, and investigator feedback to constantly improve our operational capabilities, access to biospecimens, investigator satisfaction, and stewardship of the vital resources we safeguard 5. To expand pediatric tumor procurement through continued partnership with COG 6. To enhance scientific-relevance of tissues through new processing technologies which better facilitate molecular research

描述（由申请人提供）：生物病理学中心致力于促进慢性病和癌症的诊断和治疗的改进，最终目标是提高治愈率和减少治疗副作用。与这一使命相一致，儿科生物样本部门的广泛和长期目标是继续我们的集中努力，为研究界提供与科学相关的生物样本，包括改善获得高质量儿科和青少年人类恶性、良性、患病和未参与生物样本的机会。生物样本。 pCHTN 旨在通过追求以下具体目标来直接促进和支持慢性病和癌症诊断和治疗方面的杰出研究： 1. 在适当的监管指导下，通过在标准化采集、质量控制、储存和生物样本分配方面的持续努力和创新，为研究者群体提供高质量、与科学相关的生物样本 2. 通过确保适当跟踪生物样本谱系/处理/存储以及与现有人口、临床、生物学、治疗和结果数据的联系，支持尖端研究的转化 3. 通过促进稀有标本（例如白血病、青少年癌症）的联网以及启动新的知情同意程序以促进与临床结果的联系，最大限度地提高有限资源的科学回报 4. 利用技术创新、最佳实践和研究者反馈来不断提高我们的运营能力、生物样本的获取、研究者的满意度以及我们保护的重要资源的管理 5. 通过与 COG 的持续合作扩大儿科肿瘤采购 6. 通过新的加工技术增强组织的科学相关性，更好地促进分子研究