SWOG Biospecimen Bank to Support NCI NCTN

SWOG 生物样本库将支持 NCI NCTN

• 批准号: 10610408
• 负责人: NILSA DEL CARMEN RAMIREZ MILAN
• 金额: $ 330.64万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-23 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10610408
• 关键词: Address; Adult; Biological Specimen Banks; Breast; Cancer Patient; Clinical; Clinical Data; Clinical Medicine; Clinical Research; Clinical Treatment; Clinical Trials; Clinical Trials Information for Patients; Collaborations; Collection; Colon; Component of the National Cancer Institute; Coupled; Data; Data Coordinating Center; Data Reporting; Diagnostic; Disease; Ensure; Epidemiology; Goals; Guidelines; Health protection; Human; Immunologic Monitoring; Laboratories; Link; Lung; Lymphoma; Malignant Neoplasms; Marketing; Molecular Biology; Molecular Profiling; Multiple Myeloma; National Cancer Institute; National Clinical Trials Network; Operative Surgical Procedures; Pathologic; Patients; Pediatric Hospitals; Policies; Procedures; Process; Prostate; Protocols documentation; Qualifying; Quality Control; Reporting; Research; Research Institute; Research Personnel; Residual state; Resources; Sampling; Services; Site; Southwest Oncology Group; System; Technology; Therapeutic; Translational Research; Treatment Protocols; Work; anticancer research; biobank; cancer clinical trial; cancer prevention; cancer type; clinical trial protocol; data management; data sharing; design; experience; follow-up; improved; improved outcome; innovative technologies; laboratory equipment; leukemia; melanoma; operation; participant enrollment; programs; targeted treatment; therapy outcome; translational medicine; tumor

Project Summary SWOG is an adult clinical trials cancer group within the National Clinical Trials Network (NCTN) of the National Cancer Institute (NCI). SWOG clinical trials include a range of cancer types (e.g., breast, lung, colon, prostate, leukemia, melanoma, lymphoma, and multiple myeloma). The SWOG Biospecimen Bank (Biobank), located in the Biopathology Center (part of the Abigail Wexner Research Institute of Nationwide Children's Hospital), was designed to procure, process, bank, and distribute biospecimens collected as a major component of NCI- sponsored clinical trials. These biospecimens are linked to demographic information, surgical and pathological reports, and treatment and follow-up data of study participants enrolled on SWOG protocols. Upon review and approval, biospecimens are prioritized for distribution to the specific SWOG investigators defined in the clinical trial protocols. After the needs of the planned research have been addressed, residual (legacy) banked biospecimens can be distributed to other investigators within and outside SWOG via the NCTN Navigator. The SWOG Group and Biobank Concierges can also facilitate access to SWOG legacy biospecimens that are not currently uploaded in Navigator. This process has been designed to mirror the process for legacy biospecimens on the Navigator system and includes a feasibility assessment by the SWOG Biobank and the SWOG Statistical and Data Management Center prior to proposal submission. The Biobank is a functioning and viable part of SWOG's clinical and translational medicine program, and focuses on the integration of diagnostic, therapeutic, laboratory, and clinical data to answer questions in clinical and translational research. The SWOG Biobank works under the hypothesis that banking of high quality, clinically-annotated and cancer- related human biospecimens, linked to molecular signatures/markers, will significantly facilitate and further advance clinical cancer research. To support this effort, the SWOG Biobank manages these biospecimens under strict guidelines and standard operating procedures based on current Best Practices for biorepositories and the latest laboratory technologies. The Biobank's experience, coupled with a firm commitment to quality and integrity operations, makes it uniquely able to provide an accurate and effective resource of tumor and normal samples with associated clinical, epidemiologic, and protected health information. The SWOG Biobank aims to harmonize and expand general banking practices and innovative technologies, which will continue to facilitate molecular biology research and increase investigator participation in clinical research trials via the NCI-sponsored Group Banking Committee (GBC). The SWOG Biobank also plans to support the processing, banking, and distribution of biospecimens to the Cancer Immune Monitoring and Analysis Centers (CIMACs).

项目概要 SWOG 是国家临床试验网络 (NCTN) 内的一个成人临床试验癌症小组 癌症研究所（NCI）。 SWOG 临床试验包括一系列癌症类型（例如乳腺癌、肺癌、结肠癌、前列腺癌、 白血病、黑色素瘤、淋巴瘤和多发性骨髓瘤）。 SWOG 生物样本库（Biobank），位于 生物病理学中心（全国儿童医院阿比盖尔韦克斯纳研究所的一部分） 旨在采购、处理、储存和分发作为 NCI 主要组成部分收集的生物样本 赞助临床试验。这些生物样本与人口统计信息、手术和病理信息相关 根据 SWOG 方案登记的研究参与者的报告、治疗和随访数据。经审查并 批准后，生物样本将优先分发给临床中定义的特定 SWOG 研究人员 试验方案。解决了计划研究的需求后，将剩余（遗留）存入银行 生物样本可以通过 NCTN Navigator 分发给 SWOG 内部和外部的其他研究人员。这 SWOG Group 和 Biobank Concierges 还可以帮助获取 SWOG 遗留生物样本 目前已上传到导航器中。此流程旨在反映遗留流程 Navigator 系统上的生物样本，包括 SWOG Biobank 和 提交提案之前的 SWOG 统计和数据管理中心。生物样本库是一个正常运作的 SWOG 临床和转化医学计划的可行部分，并侧重于整合 诊断、治疗、实验室和临床数据，以回答临床和转化研究中的问题。 SWOG 生物库的工作假设是高质量、经过临床注释的癌症生物库 与分子特征/标记相关的相关人类生物样本将显着促进并进一步 推进临床癌症研究。为了支持这项工作，SWOG 生物库管理这些生物样本 遵循基于当前生物样本库最佳实践的严格指南和标准操作程序 以及最新的实验室技术。生物样本库的经验以及对质量的坚定承诺 诚信经营，使其能够提供准确、有效的肿瘤和肿瘤资源。 正常样本以及相关的临床、流行病学和受保护的健康信息。 SWOG 生物库 旨在协调和扩大一般银行业务实践和创新技术，这将继续 通过以下方式促进分子生物学研究并增加研究者参与临床研究试验 NCI 发起的集团银行委员会 (GBC)。 SWOG 生物银行还计划支持处理、 生物样本的存储和分发到癌症免疫监测和分析中心 (CIMAC)。