Technical Development

技术开发

• 批准号: 9922139
• 负责人: JOEL E. RICHARDSON
• 金额: $ 36.36万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9922139
• 关键词: Anatomy; Area; Biological; Chickens; Communities; Complement; Data; Data Display; Data Set; Databases; Development; Disease; Galaxy; Gene Expression; Genes; Health; Human Development; Informatics; Intuition; Link; Modeling; Molecular; Mus; Mutation; Pathway interactions; Pattern; Phenotype; Reporter; Research Personnel; Resources; Source; Standardization; Time; Translating; Visual; Visualization; Work; Xenopus; Zebrafish; base; cell type; comparative; gene expression database; gene function; improved; indexing; informatics tool; mouse development; mouse genome; technology development; tool; web interface

PROJECT SUMMARY/ABSTRACT - TECHNICAL DEVELOPMENT The Technology Development Component of the Gene Expression Database (GXD) project complements the Curation and Computation Components by developing interfaces that allow users to realize the value offered by GXD's high-quality, integrated mouse developmental expression data and its connections with the larger biological context at Mouse Genome Informatics (MGI). By providing access to this rich resource of gene expression data, researchers can discover expression patterns crucial for understanding the function of genes and the molecular mechanisms that underlie human development, health, and disease. This component focuses on developing user interface features that provide powerful queries not possible at any other resource, present complementary data views, support rich data interactions, and offer comprehensive and intuitive navigation paths. In this component, we propose work in four broad areas: (1) develop new interfaces in support of high-throughput sequence (HTS) expression data, including access to indexed data sets and loading of selected baseline HTS data; (2) enhance the user's ability to mine GXD expression data through expanded query capabilities and data displays; (3) enhance the user's ability to interpret GXD expression data with improved graphical expression displays and enhanced links to expression data in other developmentally important species; and (4) enhance the user's ability to work with GXD expression data in larger workflows through new data upload, data download, and results combination and forwarding capabilities.   1

项目摘要/摘要 - 技术发展 基因表达数据库（GXD）项目完成的技术开发部分 通过开发允许用户实现所提供的值的接口来策划和计算组件 通过GXD的高质量，集成的鼠标发展表达数据及其与较大的连接 小鼠基因组信息学（MGI）的生物环境。通过提供对这种丰富的基因资源的访问 表达数据，研究人员可以发现表达模式对于理解基因的功能至关重要 以及人类发展，健康和疾病的基础的分子机制。此组件 专注于开发用户界面功能，这些功能在任何其他资源上都无法提供强大的查询， 介绍完整的数据视图，支持丰富的数据交互并提供全面而直观的 导航路径。在此组件中，我们在四个广泛的领域提出了工作：（1）在 支持高通量序列（HTS）表达数据，包括访问索引数据集和 加载选定的基线HTS数据； （2）增强用户通过 扩展的查询功能和数据显示； （3）增强用户解释GXD表达数据的能力 通过改进的图形表达式显示并增强了与其他发展中表达数据的链接 重要物种； （4）增强用户在较大工作流程中使用GXD表达数据的能力 通过新的数据上传，数据下载以及结果组合和转发功能。 1