HIV intervention models for criminal justice involved substance-using Black MSM

刑事司法的艾滋病毒干预模型涉及使用药物的黑人男男性接触者

基本信息

批准号：
9926365
负责人：
Kayo Fujimoto
金额：
$ 1.88万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-01 至 2022-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9926365
关键词：
AIDS prevention Acquired Immunodeficiency Syndrome Address Adherence Affordable Care Act Alcohol or Other Drugs use Back Behavior Behavioral Biological Caring Chicago Cities Clinical Trials Communities Complex County Couples Criminal Justice Data Data Sources Disease Drug usage Effectiveness Event Friends Future Geography HIV HIV Infections Health Household Imprisonment Incidence Individual Institution Integration Host Factors Intervention Intervention Studies Jail Laboratories Lead Life Link Los Angeles Marijuana Modeling Pathway Analysis Policies Population Populations at Risk Prevention Preventive Preventive Intervention Probability Publishing Randomized Research Research Personnel Risk Risk Behaviors Role Services Sexually Transmitted Diseases Shock Social Environment Social Network Specific qualifier value Structure Substance abuse problem Supervision Systems Analysis Target Populations Time United States Validation Viral Work base black men who have sex with men clinical care control trial cooking cost disparity reduction dynamic system flexibility infectious disease model intervention effect mathematical model men network models pre-exposure prophylaxis public health relevance scale up service engagement service utilization simulation social time use transmission process treatment planning young men who have sex with men

项目摘要

DESCRIPTION (provided by applicant): Large disparities in HIV rates in black men who have sex with men (BMSM) are not explained by higher engagement in risky behaviors and are particularly high among younger MSM. Despite the efficacy of several prevention interventions, reducing these disparities requires approaches that maximally engage these men's social and sexual networks. Because of frequently transient life circumstances, disruption of social and sexual networks and HIV transmission overlap with other groups, criminal justice involved (CJI) BMSM who use substances represent an important target for intervention. Although effective behavioral and structural interventions exist that target CJI populations, their successful implementation for CJI BMSM networks and communities has not been demonstrated. Furthermore, research to determine intervention impact at these larger social units is costly and does not readily lend itself to the randomized control trial approach. This proposal aims to utiliz a systems dynamic approach using an agent-based model (ABM) to estimate the effectiveness of HIV prevention and substance-abuse interventions for CJI substance-using BMSM. Our project brings together investigators with a proven track record in the study of BMSM, criminal justice settings, substance-abuse intervention, social network analysis, ABMs and HIV clinical care provision. We will adapt a previously developed core open access ABM platform (using Repast Simphony) that includes baseline national data on people and households by geography, as well as the dynamic features of the target population such as incarceration, health center, and activity (time-use) data. We will scale the ABM to three counties: Harris TX, Los Angeles CA, and Cook IL where our team has collected data for model parameterization. Our approach will assess the interplay between social and behavioral variables and viral and host factors in a matter that will be adaptive to temporal, network and setting-specific changes. Our aims are to: 1) Build upon our flexible ABM by incorporating HIV transmission and suppression probabilities at the individual level, including host/viral factors and biologic/behavioral data from HIV prevention and substance-abuse intervention studies; 2) Parameterize this ABM with multiple network data sources available to investigators in each city on specific transition periods of BMSM from the community, to jail, and back to the community/ supervision; such "shocks" lead to social and sexual network formation and disruption. We will supplement these data with newly collected data (n=50/city) specifically on network shocks and HIV prevention and treatment utilization during these critical transition periods; 3) Simulate HIV prevention interventions within criminal justice contexts using the model parameterized in Aim 2. Because our open access Repast Simphony ABM platform is widely used, we will make model parameters, specifications and variables publically available. This will allow for external validation of our findings and for additional use of the core model by others for context and community-specific integrated HIV prevention and treatment planning in at risk populations.

描述（由申请人提供）：男男性行为黑人 (BMSM) 的艾滋病毒感染率存在巨大差异，这并不是因为他们从事危险行为的比例较高，而且男男性接触者中的年轻人比例尤其高，尽管采取了多种预防干预措施，但减少这些干预措施的效果并不理想。差异需要采取最大限度地参与这些男性的社会和性网络的方法，因为经常存在短暂的生活环境、社会和性网络的破坏以及艾滋病毒传播与其他群体的重叠，使用药物的刑事司法参与（CJI）BMSM 是一个重要的目标。尽管存在针对 CJI 人群的有效行为和结构干预措施，但尚未在 CJI BMSM 网络和社区中成功实施。此外，确定干预措施对这些较大社会单位的影响的研究成本高昂，而且不容易为 CJI 群体提供帮助。该提案旨在利用基于主体的模型 (ABM) 的系统动态方法来评估 CJI 药物使用 BMSM 的 HIV 预防和药物滥用干预措施的有效性。跟踪记录对 BMSM、刑事司法环境、药物滥用干预、社交网络分析、ABM 和艾滋病毒临床护理提供的研究我们将采用先前开发的核心开放获取 ABM 平台（使用 Repast Simphony），其中包括有关人和家庭的基线国家数据。我们将 ABM 扩展到三个县：德克萨斯州哈里斯县、加利福尼亚州洛杉矶县和伊利诺伊州库克县。团队已收集数据我们的方法将评估社会和行为变量以及病毒和宿主因素之间的相互作用，以适应时间、网络和特定环境的变化。我们的目标是：1）通过以下方式建立我们灵活的 ABM。纳入个体层面的 HIV 传播和抑制概率，包括来自 HIV 预防和药物滥用干预研究的宿主/病毒因素和生物/行为数据； 2) 通过每个城市的研究人员在具体转变过程中可用的多个网络数据源来参数化此 ABM；时期BMSM 从社区到监狱，再回到社区/监督；这种“冲击”导致社会和性网络的形成和破坏，我们将用新收集的数据（n=50/城市）专门针对网络来补充这些数据。 3) 使用目标 2 中参数化的模型模拟刑事司法背景下的艾滋病毒预防干预措施。由于我们的开放获取 Repast Simphony ABM 平台已得到广泛使用，因此我们将制定模型参数、规范和变量公开。这将使我们的研究结果得到外部验证，并可供其他人额外使用核心模型，以针对高危人群制定针对具体情况和社区的艾滋病毒综合预防和治疗规划。