Longitudinal Assessment of Neural Circuits in Adolescents with Anorexia Nervosa

神经性厌食症青少年神经回路的纵向评估

基本信息

批准号：
9917857
负责人：
Jonathan E Posner
金额：
$ 71.86万
依托单位：
NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-04-07 至 2022-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9917857
关键词：
18 year old Adolescence Adolescent Adolescent and Young Adult Adult Aftercare Age Amygdaloid structure Anatomy Anorexia Nervosa Behavior Behavioral Body Weight decreased Brain Categories Characteristics Choice Behavior Chronic Corpus striatum structure Data Data Analyses Development Diagnostic Diet Diffusion Disease Disease remission Dorsal Eating Eating Behavior Food Functional Magnetic Resonance Imaging Functional disorder Habits Individual Intake Link MRI Scans Magnetic Resonance Imaging Measures Mediating Mental disorders Modeling Morbidity - disease rate Neurobiology Neurocognitive Outcome Pathologic Pharmacology Process Recovery Resistance Rest Rewards Severities Stereotyping Symptoms System Teenagers Testing Time Youth brain circuitry clinical predictors critical period design effective intervention experimental study follow-up habit learning interest longitudinal design mortality multimodality neural circuit neurobiological mechanism neuromechanism new therapeutic target novel prospective relating to nervous system reward circuitry reward processing severe mental illness tractography treatment effect treatment strategy

项目摘要

Project Summary Anorexia nervosa (AN) is a serious mental illness that confers the highest mortality rate of any psychiatric disorder. Current treatments are inadequate and no pharmacologic agents have proven effective. A better understanding of the development and pathophysiology of AN is greatly needed. We propose a longitudinal, multimodal MRI study of reward and habit circuits in youth (ages 14-18) with AN, compared with age-matched healthy controls (HC), followed over two years. We focus on adolescence because this is a critical, yet understudied, period in AN. Pathological dieting typically emerges during adolescence, and the course of AN is often determined during this period with approximately half of teens showing full recovery, whereas the rest endure persistent illness. Understanding the neurobiological mechanisms by which some teens develop persistent AN, while others remit, is critical to developing the most effective interventions. Our study will examine neural mechanisms guiding food choice and neural connectivity in mesolimbic and habit-related circuits among youth with AN who continue with illness compared with those who remit, and compared with HC. We will examine these neural circuits at baseline and study their developmental trajectories. Our Food Choice Task captures restrictive intake, a core behavioral disturbance in AN, and therefore we can directly examine the link between brain activity and eating behavior. Using longitudinal, multimodal MRI at 3- time points, we will first test whether the function and connectivity of mesolimbic reward and dorsal habit circuits predict the longer-term course of AN. Second, we will examine longitudinal changes within these two neural circuits of interest. We predict that at baseline, restrictive food choice in youth with AN will be mediated by mesolimbic reward circuitry; however, at year-2 follow-up, in teens for whom the disorder persists, restrictive food choice will be mediated by dorsal striatal habit circuitry. The study will (i) chart the developmental trajectories of reward and habit circuits in youth with AN; (ii) advance our understanding of the mechanisms by which AN persists to chronicity, and (iii) help develop targets for novel therapeutic strategies.

项目摘要神经性厌食症（AN）是一种严重的精神疾病，赋予任何精神病的死亡率最高紊乱。目前的治疗不足，没有证明有效的药理学剂。更好非常需要了解AN的发展和病理生理学。我们提出了一个纵向，与年龄相比健康对照（HC）随后两年。我们专注于青春期，因为这是一个关键的研究了，时期病理性节食通常在青春期出现，而AN的过程通常在此期间确定，大约一半的青少年显示出完全康复，其余的忍受持续疾病。了解一些青少年发展的神经生物学机制持续的A，而其他人则屈服对于制定最有效的干预措施至关重要。我们的研究将检查神经机制指导食物的选择和中唇的神经连通性，与屈服的年轻人相比与HC相比。我们将在基线时检查这些神经回路，并研究它们的发育轨迹。我们的食物选择任务捕获了限制性摄入量，这是AN中的核心行为干扰，因此我们可以直接检查大脑活动与饮食行为之间的联系。在3-上使用纵向多模式MRI 时间点，我们将首先测试中边奖励的功能和连通性和背侧习惯的功能和连通性电路预测AN的长期过程。其次，我们将检查这两个中的纵向变化感兴趣的神经回路。我们预测，在基线时，年轻人的限制性食物选择将被调解通过中唇奖励电路；但是，在2年级的随访中，在疾病持续存在的青少年中，限制性食物选择将由背纹状体习惯回路介导。该研究将（i）图表发展年轻人的奖励和习惯轨道轨迹；（ii）通过这是长期持续的，（iii）有助于开发新的治疗策略的目标。