Core 3: Neuro-Imaging Core

核心 3：神经影像核心

• 批准号: 8661056
• 负责人: Jonathan E Posner
• 金额: $ 33.05万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8661056
• 关键词: Address; Adolescent; Adult; Age; Animal Model; Animals; Archives; Behavioral; Brain; Brain imaging; Brain region; Center for Translational Science Activities; Child; Computers; Data; Data Analyses; Development; Diffusion Magnetic Resonance Imaging; Electroencephalography; Ensure; Faculty; Genes; Genetic; Genotype; Human; Image; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measures; Mediator of activation protein; Methods; Multimodal Imaging; Mus; Newborn Infant; Participant; Performance; Perfusion Weighted MRI; Physiologic pulse; Population; Procedures; Process; Productivity; Research; Research Project Grants; Scientist; Serotonin; Signal Transduction; Staging; Statistical Methods; System; Training; behavior measurement; brain behavior; computerized data processing; data integrity; density; imaging modality; infancy; neuroimaging; quality assurance

The Neuroimaging core will acquire and process multimodal imaging data to enhance significantly our understanding of the effects of serotonergic signaling in the brain. It will provide the extensive expertise of its faculty and staff for conducting brain imaging research in mice, newborn babies, children, and adolescents using structural magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), perfusion MRI, MR spectroscopy (MRS), and high density EEG. By applying validated and reliable imaging and statistical methods, the core will ensure uniformity, consistency, and economy of scale across all projects of the center. The Core will contribute significantly to accelerate our understanding of the disturbances in the brain caused by serotonin availability at various stages during early brain development. To quantify disturbances in various cortical and subcortical brain circuits, research projects will acquire and analyze multimodal MR data, and compute various brain measures, including EEG power and coherence, local volumes of brain regions, and between-region connectivity. These measures will be correlated with genotype data to discern the gene-brain-behavior correlates across species, and age ranges from infancy to adulthood. Furthermore, the core will ensure data integrity by (1) quantifying identical brain measures using the same imaging and statistical methods across all projects; (2) rigorously evaluating methods developed to address better the challenges in analyzing data from a wide age range of participants; and (3) exploiting economy of scale by applying common components of image and statistical analyses across all projects, thereby greatly enhancing the efficiency and productivity of the center.

神经影像学核心将获取和处理多模式成像数据，从而显着增强我们对脑部能信号在大脑中的影响的理解。它将提供其教职员工的广泛专业知识，用于在老鼠，新生婴儿，儿童和青少年进行大脑成像研究 使用结构磁共振成像（MRI），扩散张量成像（DTI），灌注MRI，MR光谱学（MRS）和高密度EEG。通过采用经过验证且可靠的成像和统计方法，核心将确保该中心所有项目中的规模统一，一致性和规模经济。 核心将在早期大脑发育期间各个阶段在各个阶段加速我们对大脑障碍的理解做出重大贡献。为了量化各种皮质和皮质下脑回路的干扰，研究项目将获取和分析多模式MR 数据并计算各种大脑测量，包括脑电图和连贯性，大脑区域的局部体积以及区域之间的连通性。这些措施将与基因型数据相关，以辨别跨物种之间的基因 - 脑行为相关，从婴儿期到成年期。此外，核心将通过（1）使用相同的成像和相同的大脑测量来确保数据完整性 所有项目的统计方法； （2）制定的严格评估方法是为了解决来自广泛年龄范围参与者的数据的更好的挑战； （3）通过在所有项目中应用图像和统计分析的共同组成部分来利用规模经济，从而大大提高了中心的效率和生产率。