Bioassay Facility Core

生物测定设施核心

基本信息

批准号：
9918114
负责人：
JENNIFER C FUNG
金额：
$ 46.74万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-22 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9918114
关键词：
Air Animal Model Area Biological Biological Assay Biological Models Biological Monitoring Biological Process California Cells Chemical Exposure Chemical Models Chemicals Communities Core Facility Data Analyses Defect Detection Development Disease Ensure Environment Environmental Exposure Environmental Health Epidemiology Equipment Evaluation Evolution Fostering Funding Goals Growth Hazardous Waste Health Health Professional Human Individual Investments Ions Laboratories Link Mass Spectrum Analysis Measurement Measures Monitor Morphology Mus Organism Pathway interactions Peptides Planet Earth Poison Procedures Proteomics Reaction Reproducibility Research Research Design Research Personnel Resources Sampling Scientist Services Shotguns Soil Specialist Specimen Standardization Stream Technical Expertise Technology Tissue Sample Tissues Translations Water Xenograft procedure base consumer product cost cost effective data integration experimental study high throughput screening human tissue in vivo innovation member new technology novel physiologic model programs reproductive screening small molecule libraries tissue culture tissue/cell culture tool toxicant

项目摘要

ABSTRACT - BIOASSAY FACILITY CORE The EaRTH Center Bioassay Facility Core will provide the enabling technology and expertise needed to advance cross-disciplinary environmental studies across the UCSF EaRTH Center research community. The EaRTH Center Bioassay Facility Core will offer several facilities to cover the majority of the EaRTH Center researchers needs: 1) an extensive biomonitoring facility providing chemical detection and measurement in many different media including air, water, soil, hazardous waste streams, consumer products and biological or human tissues; 2) state of the art SWATH mass spectrometry as well as traditional proteomics for assessing a chemical's effect on biological processes; 3) access to an extensive chemical library combined with ability to perform high- throughput in vivo chemical screening in a model organism and tissue culture; 4) novel xenografting of human tissue into mice to more realistically model chemical exposures. The Core therefore will enable EaRTH Center researchers to push the boundaries of environmental research by providing high-throughput, efficient and cost- effective chemical evaluation technologies.

摘要 - 生物测定设施核心 EaRTH 中心生物测定设施核心将提供所需的支持技术和专业知识在加州大学旧金山分校地球中心研究界推进跨学科环境研究。这 EaRTH 中心生物测定设施核心将提供多个设施来覆盖 EaRTH 中心的大部分区域研究人员需要：1）广泛的生物监测设施，在许多领域提供化学检测和测量不同的介质，包括空气、水、土壤、危险废物流、消费品以及生物或人类纸巾； 2) 最先进的 SWATH 质谱分析以及用于评估化学品的传统蛋白质组学对生物过程的影响； 3) 访问广泛的化学库以及执行高性能的能力模型生物和组织培养物中体内化学筛选的通量； 4）新型人类异种移植将组织植入小鼠体内，以更真实地模拟化学暴露。因此，核心将启用 Earth Center 研究人员通过提供高通量、高效且成本低廉的技术来突破环境研究的界限有效的化学评价技术。