2020 Ligand Recognition & Molecular Gating GRC/GRS

2020年配体认可

• 批准号: 9913047
• 负责人: Alessio Accardi
• 金额: $ 2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-01 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9913047
• 关键词: ATP-Binding Cassette Transporters; Accounting; Address; Age; Binding; Cardiovascular Diseases; Carrier Proteins; Collaborations; Communities; Complex; Cryoelectron Microscopy; Development; Disabled Persons; Disease; Drug Targeting; Educational process of instructing; Endocrine System Diseases; Ensure; Equilibrium; Female; Fostering; Functional disorder; Future; G-Protein-Coupled Receptors; Gender; Goals; Health; Heart Diseases; Hour; Human; Intervention; Ion Channel; Ion Channel Protein; Italy; Joints; Ligand Binding; Ligands; Medical; Membrane Proteins; Metabolic Diseases; Minority Participation; Molecular; Molecular Conformation; Myopathy; Neuromuscular Diseases; Pharmaceutical Preparations; Pharmacologic Substance; Physiological; Physiology; Play; Postdoctoral Fellow; Process; Property; Protein Family; Proteins; Recruitment Activity; Regulation; Renaissance; Research; Research Personnel; Resort; Role; Science; Scientist; Senior Scientist; Signal Transduction; Slide; Structural Protein; Structure; Techniques; Woman; Work; experience; graduate student; improved; insight; interest; meetings; molecular recognition; neglect; nervous system disorder; novel strategies; particle; posters; programs; protein complex; protein function; public health relevance; research and development; solute; structured data; success; symposium; therapeutic target; transmission process

SUMMARY: The 2020 Gordon Research Conference (GRC) on Ligand Recognition and Molecular Gating will be held from March 15th-20th at the Renaissance Tuscany Il Ciocco Resort, Italy. The GRC will be preceded by the related Gordon Research Seminar (GRS), which is organized by and for young scientists (March 14th-15th). The topic of this GRC/GRS combination is unique, as it addresses the molecular mechanisms of three important classes of membrane proteins: ion channels, active transporters, and G-protein coupled receptors (GPCRs). These proteins are central to human physiology and their dysfunction leads to a large number of neuromuscular, endocrine and metabolic diseases. These proteins are major therapeutic targets; more than 50% of current drugs on the market target them. Therefore, elucidating their molecular mechanisms is essential to enable new opportunities for intervention, which ultimately will lead to improvement of human health. The central focus of this GRC/GRS is on the molecular mechanisms underlying ligand recognition and binding, ligand-induced conformational changes, solute transport, regulation of function, and signal transmission. Current focus is on elucidating the structures of these proteins and on how the structural data illuminates the mechanisms and physiological roles of these proteins. Our understanding of membrane protein function is undergoing a major leap forward, fueled by multiple technological breakthroughs, the most important of which is the revolution in electron cryo- microscopy that led to the determination of several medically important structures of human transporters, channels and signaling complexes, such as Na+ channels, multidrug ABC transporters and GPCR/G- protein complexes. Progress has also been made in understanding fundamental processes that are key to the function of these proteins, such as gating mechanisms of major channels, dynamic rearrangements and the formation of different signaling complexes. Efforts to identify the function of uncharacterized membrane protein families are also underway to understand their function in human physiology and disease. This GRC is unique as it brings together scientists who work on these three different classes of membrane proteins and are located on different continents, and thus do not meet regularly. They will benefit tremendously from these interactions as these membrane proteins share common mechanistic principles and can be studied by a vast array of techniques, many of which will be represented in this conference. The program will have around 40 speakers, a mix of well-established leaders in the field, young investigators, postdocs and graduate students. Nine speaker sessions and several poster sessions will address the major properties of transporters, ion channels, and GPCRs. The GRC/GRS on Ligand Recognition and Molecular Gating will provide a platform for the presentation and discussion of latest research results and for the establishment of new collaborations.

摘要：有关配体识别和分子的2020年戈登研究会议（GRC） 门控将于3月15日至20日在意大利文艺复兴时期的托斯卡纳IL Ciocco Resort举行。 GRC会 之前是相关的Gordon Research研讨会（GRS），该研讨会是由年轻人组织的 科学家（3月14日至15日）。此GRC/GRS组合的主题是独一无二的，因为它解决了 三种重要类膜蛋白的分子机制：离子通道，活性转运蛋白， 和G蛋白偶联受体（GPCR）。这些蛋白质是人类生理及其的核心 功能障碍导致大量神经肌肉，内分泌和代谢疾病。这些蛋白质 是主要的治疗靶标；当前市场上有50％以上的药物以它们为目标。所以， 阐明其分子机制对于启用新的干预机会至关重要，这 最终将导致人类健康的改善。该GRC/GRS的主要重点是分子 配体识别和结合，配体诱导构象变化的机制，溶质 运输，功能调节和信号传递。当前的重点是阐明 这些蛋白质以及结构数据如何阐明这些蛋白质的机制和生理作用 蛋白质。通过 多个技术突破，其中最重要的是电子冷冻的革命 显微镜导致确定人类转运蛋白的几种医学重要结构 通道和信号复合物，例如Na+通道，多药ABC转运蛋白和GPCR/G- 蛋白质复合物。在理解基本过程中也取得了进展，这是 这些蛋白质的功能，例如主要通道的门控机制，动态重排和 不同信号复合物的形成。努力确定未表征的膜的功能 蛋白质家族也正在进行了解其在人类生理和疾病中的功能。 这个GRC是独一无二的，因为它汇集了从事这三个不同类别的科学家 膜蛋白，位于不同大陆，因此不经常相遇。他们会的 这些膜蛋白具有共同的机制，从这些相互作用中受益匪浅 原理可以通过各种技术来研究，其中许多将在此中代表 会议。该计划将有大约40名演讲者，这是该领域成熟的领导者的混合 年轻的调查员，博士后和研究生。九个演讲者会议和几个海报会议 将解决转运蛋白，离子通道和GPCR的主要特性。配体上的grc/grs 识别和分子门控将为介绍和讨论提供一个平台 研究结果和建立新的合作。