TRAINING IN NEUROTHERAPUETICS AND DEVELOPMENT FOR ACADEMIC SCIENTISTS

学术科学家的神经治疗学和发展培训

• 批准号: 9910467
• 负责人: MICHAEL A. ROGAWSKI
• 金额: $ 26.49万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-15 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9910467
• 关键词: ADME Study; Academia; Address; Area; Biologic Development; Biological Assay; Biological Markers; Biological Response Modifier Therapy; Brain; Brain Diseases; Cell Therapy; Critiques; Development; Development Plans; Educational Curriculum; Elements; Faculty; Formulation; Funding; Future; Gene Proteins; Goals; Government; Grant; Individual; Industry; Intellectual Property; Knowledge; Lead; Learning; Logistics; Medicine; Mentors; Mentorship; Monitor; Participant; Pharmaceutical Chemistry; Postdoctoral Fellow; Process; Quality of life; Research; Research Personnel; Resources; Scientist; Series; Specialist; Structure; Students; Teacher Professional Development; Time; Training; Training Programs; United States National Institutes of Health; Vision; Work; animal efficacy; apprenticeship; base; design; disability; drug development; drug discovery; efficacy testing; experience; improved; instructor; interest; lecturer; lectures; member; nervous system disorder; recruit; responsible research conduct; safety testing; skills; small molecule; social media; success; teacher

Project Summary/Abstract This project will develop and implement a training program in neurotherapeutics discovery and development for faculty members and advanced postdoctoral fellows, centered around a 3½-day short course that will provide the trainees with the various knowledge elements required to discover and advance a neurotherapeutic agent to IND. Following the short course, the training program will continue for a two-year period in which students will have individualized mentoring and assessment. The training, which is designed to be applicable to diverse diseases of the nervous system, will equip students with a broad understanding of the various component steps in the neurotherapeutics drug discovery and development process. Students will learn how to identify a good drug discovery target; how to construct an assay; the elements of medicinal chemistry; how to conduct animal efficacy testing; the principles of ADME studies, safety testing, and formulation; the principles of experimental medicine and biomarkers; the steps required to prepare an IND document and the principles for interacting with the FDA; the principles of intellectual property as they relate to neurotherapeutics discovery and development; and how to seek funding for academic drug discovery research. They will also receive training in responsible conduct of research. Students will be equipped with the skills to develop and coordinate an entire drug discovery and development effort, and to work collaboratively with experts in each of the component areas. The training will combine didactic lectures with active engagement activities in which the students will be challenged to utilize the lecture material to work through their own drug discovery project plan with the guidance of the area experts. The 3½-day short course (followed by two-years of mentorship and assessment) will be offered annually, a total of five times.

项目概要/摘要 该项目将制定并实施神经治疗药物发现和治疗方面的培训计划 以 3.5 天的短期课程为中心，为教师和高级博士后研究员提供发展机会 这将为学员提供发现和推进某一领域所需的各种知识要素 短期课程结束后，培训计划将持续两年。 在此期间，学生将接受个性化的指导和评估。 适用于神经系统的多种疾病，将使学生获得广泛的理解 神经治疗药物发现和开发过程中的各个组成步骤。 学生将学习如何确定良好的药物发现目标；如何构建分析的要素； 药物化学；如何进行动物功效测试；ADME研究原理、安全性测试、 和制剂；实验医学和生物标志物的原理；制备药物所需的步骤； IND 文件以及与 FDA 互动的原则； 以及如何为学术药物寻求资金 他们还将接受负责任的研究培训。 具备开发和协调整个药物发现和开发工作的技能，并 培训将与各个组成领域的专家合作。 积极参与活动，学生将面临利用讲座材料进行工作的挑战 在该领域专家的指导下通过他们自己的药物发现项目计划 3.5 天的短期课程。 （随后是两年的指导和评估）每年都会提供，总共五次。