Training in Neurotherapeutics for Academic Scientists

学术科学家神经治疗学培训

基本信息

批准号：
10539175
负责人：
MICHAEL A. ROGAWSKI
金额：
$ 27万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10539175
关键词：
ADME Study Academia Address Advocacy American Antibodies Area Biological Biological Assay Biological Products Biological Response Modifier Therapy Brain Brain Diseases Breathing Communities Continuing Education Critiques Development Development Plans Educational Curriculum Elements Event Faculty Formulation Funding Future Gene Transduction Agent Goals Government Individual Industry Intellectual Property Knowledge Lead Learning Legal patent Mentors Monoclonal Antibodies Oligonucleotides Participant Pharmaceutical Chemistry Postdoctoral Fellow Process Quality of life Research Research Personnel Scientist Series Societies Special Event Specialist Students Teacher Professional Development Time Toxicology Training Training Programs Viral Vector Vision Work animal efficacy apprenticeship base biological development career commercialization design disability drug development drug discovery efficacy testing experience improved instructor interest lecturer lectures meetings member nervous system disorder responsible research conduct safety testing skills small molecule success teacher

项目摘要

Project Summary/Abstract This project will develop and implement a training program in neurotherapeutics discovery and development for faculty members and advanced postdoctoral fellows, centered around a 4-day short course that will provide the trainees with the various knowledge elements required to discover and advance a neurotherapeutic agent – either small molecule or biological – to IND. The course is offered in conjunction with the American Society for Experimental Neurotherapeutics (ASENT). The training, which is designed to be applicable to diverse diseases of the nervous system, will equip students with a broad understanding of the various component steps in the neurotherapeutics drug discovery and development process. Students will learn how to identify a good drug discovery target; how to construct an assay; the elements of medicinal chemistry; how to conduct animal efficacy testing; the principles of ADME studies, safety testing, and formulation; special considerations for development of biological products, including monoclonal antibodies, oligonucleotides and viral vector gene therapies; the steps required to prepare an IND document and the principles for interacting with the FDA; the principles of intellectual property as they relate to neurotherapeutics discovery and development; and how to seek funding for academic drug discovery research. They will also receive training in responsible conduct of research. Students will be equipped with the skills to develop and coordinate an entire drug discovery and development effort, and to work collaboratively with experts in each of the component areas. The training will combine didactic lectures with active engagement activities in which the students will be challenged to utilize the lecture material to work through their own drug discovery project plan with the guidance of the area experts. The 4-day short course will be offered annually, a total of five times. After attending the short course, trainees will participate in ongoing activities that provide continuing professional development through engagement with ASENT.

项目摘要/摘要该项目将开发并实施神经疗法发现和教职员工和高级博士后研究员的发展，以4天的短期课程为中心这将为培训提供发现和推进A所需的各种知识要素神经治疗剂 - 小分子或生物学 - 到IND。该课程与美国实验神经疗法学会（ASENT）。培训被设计为适用于神经系统的潜水疾病，将使学生对神经治疗药物发现和开发过程中的各个组件步骤。学生会了解如何识别良好的药物发现目标；如何构建测定；医疗元素化学;如何进行动物效率测试； ADME研究，安全测试和公式;开发生物产品的特殊考虑，包括单克隆抗体，寡核苷酸和病毒载体基因疗法；准备IND文档所需的步骤和与FDA互动的原则；与之相关的知识产权原则神经疗法的发现和发展；以及如何寻求学术药物发现资金研究。他们还将接受负责任的研究培训。学生将配备开发和协调整个药物发现和开发工作以及工作的技能与每个组件领域的专家合作。培训将将教学演讲与积极的参与活动，将挑战学生利用演讲材料工作的活动通过他们自己的药物发现项目计划，并在该地区专家的指导下。 4天的短期课程每年将提供五次。参加短期课程后，学员将参加正在进行的活动，通过与Asent的参与为持续的专业发展。