Investigation of Transtibial Amputee Ability to Coordinate Residual Antagonistic Muscle Activations with Direct Electromyographic Control for the Enhancement of Postural Control

研究小腿截肢者通过直接肌电图控制协调残余拮抗肌激活以增强姿势控制的能力

• 批准号: 9911097
• 负责人: Aaron Fleming
• 金额: $ 3.95万
• 依托单位: NORTH CAROLINA STATE UNIVERSITY RALEIGH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-11-01 至 2022-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9911097
• 关键词: Adopted; Amputation; Amputees; Ankle; Computer Simulation; Decision Making; Drops; Electromyography; Equilibrium; Exposure to; Fostering; Goals; Human; Investigation; Life; Limb Prosthesis; Limb structure; Locomotion; Lower Extremity; Measures; Mechanics; Muscle; Muscle Contraction; Musculoskeletal Equilibrium; Nature; Outcome; Outcome Study; Pattern; Performance; Periodicity; Posture; Prosthesis; Public Health; Quality of life; Research; Research Personnel; Residual state; Shapes; Source; System; Technology; Testing; Torque; Training; User-Computer Interface; Virtual System; Walking; Weight; Work; ankle joint; arm; clinical translation; dynamic system; improved; limb amputation; myoelectric control; powered prosthesis; prosthesis control; rehabilitation engineering; relating to nervous system; response; restoration; skills; virtual

PROJECT SUMMARY The ability to control standing posture is an essential aspect of daily living and this ability is altered for lower-limb amputees. With the loss of active ankle joint control, amputees have decreased stability and adapt compensatory strategies of control, favoring their intact limb. A small amount of work has been done to assist postural control with a powered ankle prosthesis, though this control is ill-fitted for situations of expected perturbation due to the ability to produce only reactive responses. Normative responses involve anticipatory changes in ankle- mechanics before a perturbation occurs. Direct electromyographic (EMG) control provides promise as a means of incorporating high-level human intent via descending neural commands for the restoration of postural control mechanisms at the prosthetic ankle joint. Current work has only tested the potential for direct EMG control of a powered prosthesis with only single-muscle input or with cyclic tasks (like walking). Postural control mechanisms require coordinated control from antagonistic ankle muscles to generate patterns of reciprocal and coactivation at the ankle-joint. It is unknown then whether amputees are able to coordinate residual muscle activations and if direct EMG control with a powered ankle prosthesis can assist postural control under expected perturbation. The objective of my proposed work is to develop a deeper understanding of residual antagonistic shank muscles as a control source to help restore the ability to generate postural control mechanisms at the amputated ankle. The proposed research will facilitate my long-term goal of developing technology that will improves prosthesis functionality and amputee quality of life. Specifically, direct EMG control from residual antagonistic muscle can take advantage of human intent via descending neural commands, allowing for anticipatory modulation of prosthetic ankle-joint mechanics. Thus, I propose the following research aims: 1) To investigate residual antagonistic muscle as an input for direct EMG control; and 2) To assess the extent to which transtibial amputees use direct EMG control of a powered ankle prosthesis with antagonistic residual muscles to generate postural control mechanisms under expected perturbations. To execute my aims, I will test the ability of residual antagonist muscles in a virtual system and powered ankle prosthesis separately. I will use two virtual systems to test the ability for amputees to 1) generate varying levels of activation and coactivation and 2) control a highly dynamic system. I will quantify the ability to complete both tasks and analyze the correlation in performance. I will then use an expected perturbation testing paradigm to test the ability for amputees to use direct EMG control of a powered ankle prosthesis to enhance postural control. I will quantify the contribution of the powered prosthetic ankle to overall stability. Overall the outcomes will provide a deeper understanding of residual antagonist muscles as a control source and demonstrate the feasibility of direct EMG control for the restoration of postural control mechanisms at the prosthetic ankle. The non-invasive nature of my work also has great potential for clinical translations of direct EMG control.

项目概要 控制站立姿势的能力是日常生活的一个重要方面，这种能力会因下肢而改变 截肢者。随着踝关节主动控制的丧失，截肢者的稳定性下降并适应代偿性 控制策略，有利于他们完整的肢体。已完成少量工作来协助姿势控制 带有动力踝关节假肢，尽管这种控制不适合由于预期扰动的情况 仅产生反应性反应的能力。规范反应涉及踝关节的预期变化 扰动发生之前的力学。直接肌电图 (EMG) 控制作为一种手段提供了希望 通过下行神经命令整合高级人类意图以恢复姿势控制 假肢踝关节的机制。目前的工作仅测试了直接肌电图控制的潜力 仅具有单肌肉输入或循环任务（如行走）的动力假肢。姿势控制机制 需要对抗性踝关节肌肉的协调控制，以产生交互和共同激活的模式 在踝关节处。目前尚不清楚截肢者是否能够协调残余肌肉的激活和 使用电动踝关节假体进行直接肌电图控制是否可以在预期扰动下辅助姿势控制。 我提出的工作的目的是加深对残余拮抗小腿肌肉的了解 作为控制源，帮助恢复截肢脚踝产生姿势控制机制的能力。 拟议的研究将促进我开发改进假肢技术的长期目标 功能和截肢者的生活质量。具体来说，来自残余拮抗肌的直接肌电图控制可以 通过下行神经命令利用人类意图，从而实现预期调节 假肢踝关节力学。因此，我提出以下研究目标：1）研究残差 拮抗肌作为直接肌电图控制的输入； 2) 评估小腿截肢者的损伤程度 使用肌电图直接控制带有拮抗残余肌肉的动力踝关节假体来产生姿势 预期扰动下的控制机制。 为了实现我的目标，我将在虚拟系统和动力踝关节中测试残余拮抗肌的能力 假肢分开。我将使用两个虚拟系统来测试截肢者的能力：1）生成不同级别 激活和共激活的过程；2）控制高度动态的系统。我将量化完成这两件事的能力 任务并分析绩效的相关性。然后我将使用预期的扰动测试范例来 测试截肢者使用电动踝关节假体的直接肌电图控制来增强姿势控制的能力。 我将量化动力假肢脚踝对整体稳定性的贡献。总体而言，结果将提供 更深入地了解残余拮抗肌作为控制源并证明其可行性 直接肌电图控制，用于恢复假肢踝关节的姿势控制机制。非侵入式 我的工作性质对于直接肌电图控制的临床转化也具有巨大的潜力。