Investigation of Transtibial Amputee Ability to Coordinate Residual Antagonistic Muscle Activations with Direct Electromyographic Control for the Enhancement of Postural Control

研究小腿截肢者通过直接肌电图控制协调残余拮抗肌激活以增强姿势控制的能力

• 批准号: 9911097
• 负责人: Aaron Fleming
• 金额: $ 3.95万
• 依托单位: NORTH CAROLINA STATE UNIVERSITY RALEIGH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-11-01 至 2022-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9911097
• 关键词: Adopted; Amputation; Amputees; Ankle; Computer Simulation; Decision Making; Drops; Electromyography; Equilibrium; Exposure to; Fostering; Goals; Human; Investigation; Life; Limb Prosthesis; Limb structure; Locomotion; Lower Extremity; Measures; Mechanics; Muscle; Muscle Contraction; Musculoskeletal Equilibrium; Nature; Outcome; Outcome Study; Pattern; Performance; Periodicity; Posture; Prosthesis; Public Health; Quality of life; Research; Research Personnel; Residual state; Shapes; Source; System; Technology; Testing; Torque; Training; User-Computer Interface; Virtual System; Walking; Weight; Work; ankle joint; arm; clinical translation; dynamic system; improved; limb amputation; myoelectric control; powered prosthesis; prosthesis control; rehabilitation engineering; relating to nervous system; response; restoration; skills; virtual

PROJECT SUMMARY The ability to control standing posture is an essential aspect of daily living and this ability is altered for lower-limb amputees. With the loss of active ankle joint control, amputees have decreased stability and adapt compensatory strategies of control, favoring their intact limb. A small amount of work has been done to assist postural control with a powered ankle prosthesis, though this control is ill-fitted for situations of expected perturbation due to the ability to produce only reactive responses. Normative responses involve anticipatory changes in ankle- mechanics before a perturbation occurs. Direct electromyographic (EMG) control provides promise as a means of incorporating high-level human intent via descending neural commands for the restoration of postural control mechanisms at the prosthetic ankle joint. Current work has only tested the potential for direct EMG control of a powered prosthesis with only single-muscle input or with cyclic tasks (like walking). Postural control mechanisms require coordinated control from antagonistic ankle muscles to generate patterns of reciprocal and coactivation at the ankle-joint. It is unknown then whether amputees are able to coordinate residual muscle activations and if direct EMG control with a powered ankle prosthesis can assist postural control under expected perturbation. The objective of my proposed work is to develop a deeper understanding of residual antagonistic shank muscles as a control source to help restore the ability to generate postural control mechanisms at the amputated ankle. The proposed research will facilitate my long-term goal of developing technology that will improves prosthesis functionality and amputee quality of life. Specifically, direct EMG control from residual antagonistic muscle can take advantage of human intent via descending neural commands, allowing for anticipatory modulation of prosthetic ankle-joint mechanics. Thus, I propose the following research aims: 1) To investigate residual antagonistic muscle as an input for direct EMG control; and 2) To assess the extent to which transtibial amputees use direct EMG control of a powered ankle prosthesis with antagonistic residual muscles to generate postural control mechanisms under expected perturbations. To execute my aims, I will test the ability of residual antagonist muscles in a virtual system and powered ankle prosthesis separately. I will use two virtual systems to test the ability for amputees to 1) generate varying levels of activation and coactivation and 2) control a highly dynamic system. I will quantify the ability to complete both tasks and analyze the correlation in performance. I will then use an expected perturbation testing paradigm to test the ability for amputees to use direct EMG control of a powered ankle prosthesis to enhance postural control. I will quantify the contribution of the powered prosthetic ankle to overall stability. Overall the outcomes will provide a deeper understanding of residual antagonist muscles as a control source and demonstrate the feasibility of direct EMG control for the restoration of postural control mechanisms at the prosthetic ankle. The non-invasive nature of my work also has great potential for clinical translations of direct EMG control.

项目摘要 控制站立姿势的能力是日常生活的重要方面，对于下limb而言，这种能力会改变 截肢者。随着主动踝关节控制的损失，截距降低了稳定性并适应补偿性 控制策略，偏爱他们完整的肢体。为了帮助姿势控制做了少量工作 具有动力的脚踝假体，尽管这种控制不适合因预期扰动而导致的情况。 仅产生反应响应的能力。规范反应涉及踝关节的预期变化 发生扰动之前的力学。直接肌电图（EMG）控制提供了前途 通过下降神经命令恢复姿势控制的高级人类意图 假体踝关节的机制。当前的工作仅测试了直接控制A的潜力 仅带有单肌肉输入或循环任务（例如步行）的假肢。姿势控制机制 需要从拮抗踝肌肉进行协调的控制，以产生相互和共激活的模式 在脚踝关节上。尚不清楚截肢者是否能够协调残留的肌肉激活和 如果使用动力脚踝假体的直接控制EMG控制可以在预期的扰动下有助于姿势控制。 我提议的工作的目的是对残留的拮抗柄肌肉有更深入的了解 作为控制源，可以帮助恢复在截肢踝关节上生成姿势控制机制的能力。 拟议的研究将促进我开发技术的长期目标，以改善假体 功能和截肢者的生活质量。具体而言，残留拮抗肌肉的直接控制可以控制EMG 通过下降神经命令利用人类意图，可以预期调制 假体脚踝合并力学。因此，我提出以下研究的目的：1）研究残留 拮抗肌肉作为直接EMG控制的输入； 2）评估跨态截形的程度 使用对拮抗残留肌肉的动力踝关节假体的直接控制控制姿势 预期扰动下的控制机制。 为了执行我的目标，我将测试在虚拟系统中残留的拮抗剂肌肉的能力并为脚踝提供动力 假体分别。我将使用两个虚拟系统来测试截距的能力至1）生成不同的级别 激活和共激活以及2）控制高度动态的系统。我将量化完成两者的能力 任务并分析性能的相关性。然后，我将使用预期的扰动测试范例 测试截肢者使用对动力踝关节假体的直接EMG控制以增强姿势控制的能力。 我将量化动力假肢对整体稳定性的贡献。总体而言，结果将提供 对残留拮抗剂肌肉作为对照组的更深入了解，并证明了 直接控制姿势控制机制在假体踝关节上的直接控制。无创的 我工作的性质也具有直接EMG控制的临床翻译的巨大潜力。