Neurocorrelates of alterations in facial expressivity in youth at clinical high-risk for psychosis

临床精神病高危青少年面部表情变化的神经相关性

• 批准号: 9911724
• 负责人: Tina Gupta
• 金额: $ 4.04万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-01 至 2021-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9911724
• 关键词: Accounting; Adolescent; Age; Anxiety; Area; Attention; Award; Behavior; Behavioral; Childhood; Chronic Disease; Clinical; Clip; Code; Cognitive; Data; Data Collection; Depressed mood; Diagnosis; Educational workshop; Emotional; Emotions; Environment; Equipment; Exhibits; Face; Facial Expression; Facial Muscles; Family member; Feeling; Film; Functional disorder; Gender; Hand; Home environment; Human; Impairment; Individual; Institution; Insula of Reil; Intervention; Interview; Knowledge; Learning; Light; Link; MRI Scans; Measures; Mental Depression; Mental Health; Methodology; Methods; Motor; Movement; Nature; Negative Valence; Neurosciences; Outcome; Participant; Pathogenesis; Patients; Pharmaceutical Preparations; Population; Positive Valence; Process; Prospective Studies; Psychotic Disorders; Questionnaires; Reporting; Research; Resources; Risk; Schizophrenia; Social Functioning; Societies; Structure; Symptoms; Training; Universities; Withdrawal; Work; Youth; adolescent patient; aged; base; career development; clinical predictors; experience; high risk; high risk population; insight; multimodality; neural circuit; novel; positive emotional state; relating to nervous system; showing emotion; social; theories; therapy development

Project Summary It is established that individuals diagnosed with schizophrenia report experiencing emotions (e.g., joy, sadness), however, facial expressivity is blunted meaning the facial expressions that correspond with what we would expect to see with emotions such as joy are not facially expressed). To date, it is unknown what the nature of facial expressivity is prior to the onset of psychosis and if we see this discrepancy with the experience of emotion. One study found after hand-coding home-videos (during childhood/adolescents) of patients that later developed schizophrenia, these individuals showed decreased positive facial expressions and increased negative facial expressions (7). This study, however, is the first to unravel the nature of facial expressivity among adolescents at clinical high-risk (CHR) for developing psychosis, which can have critical translational implications given the detrimental impacts alterations in facial expressivity can have in social relationships, resulting in social withdrawal, isolation, and other mental health issues (e.g., anxiety and depression). Furthermore, understanding facial expressivity may be informative for identifying factors contributing to the pathogenesis of psychosis, decline in social functioning, and increased symptoms. Additionally, the proposed study can allow for analysis of underlying neural circuitry (both independent of behavior data and in terms of relationships with facial expressivity) which is needed within this area. In the current study, a total of 100 participants will participate in clinical interviews, a cognitive battery, an emotionally evocative film clip viewing task, and a magnetic resonance imaging (MRI) scan. The project aims to (1) determine if CHR youth exhibit alterations in facial expressions during emotionally evocative film clip viewing task compared to controls (also assessing the experience of emotion) (2) determine relevant neural circuitry underlying facial expressivity using structural and functional connectivity analyses, and (3) examine relationships between facial expressivity and social functioning and symptoms at baseline and 12 months later. The training plan proposed, in addition to training in theory and career development, relies on methodology in (1) human and automated facial analysis and (2) structural/functional connectivity. Training environment: The project will take place at Northwestern University which is an excellent training environment in which (1) there are valuable and accessible resources (e.g., equipment, courses, workshops) and (2) both the Sponsor and Co-Sponsor are located at this institution and have expertise in the areas of motor/neuroscience (connectivity analyses), and emotion, respectively. Training plan: The training plan will consist of learning about theory, data collection/processing/analysis and interpretation in Year 1 and Year 2. Furthermore, coursework and career development will be topics of focus through the award period. The training from this award is an extension of current knowledge and offers the opportunity to integrate novel theory and methods in emotional processes.

项目摘要 已经确定，被诊断患有精神分裂症报告的人经历了情绪（例如，欢乐， 然而，悲伤），面部表情是钝化的意思，意味着与我们相对应的面部表情 期望以喜悦之类的情感看到）。迄今为止，尚不清楚 面部表情的性质是在精神病发作之前，如果我们看到这种差异 情绪的经验。一项在手工编码的家庭视频（在儿童/青少年期间）之后发现的一项研究 后来发展精神分裂症的患者，这些人表现出阳性面部表情降低 并增加了负面表情（7）。但是，这项研究是第一个揭示面部本质的研究 临床高风险（CHR）的青少年之间的表现性，用于发展精神病，这可能具有关键 鉴于面部表情性的改变可能在社会中产生不利影响的影响 关系，导致社会戒断，孤立和其他心理健康问题（例如，焦虑和 沮丧）。此外，理解面部表情性可能是识别因素的信息 促进精神病的发病机理，社会功能下降和症状增加。 此外，拟议的研究可以允许分析潜在的神经回路（均与 行为数据以及与面部表现力的关系），这是在该领域内需要的。在 当前的研究，共有100名参与者将参加临床访谈，认知电池，一个 情感令人回味的膜剪辑查看任务和磁共振成像（MRI）扫描。该项目的目标 （1）确定在情绪令人回味的薄膜剪辑中，CHR青年是否表现出面部表情的改变 与对照组相比（也评估情感的经验）相比，查看任务（2）确定相关神经 使用结构和功能连接分析的面部表达能力的电路，（3）检查 面部表情和社会功能与基线症状之间的关系以及12个月后。 除了在理论和职业发展方面的培训外，提出的培训计划还依赖于 （1）人类和自动化的面部分析以及（2）结构/功能连通性。培训环境： 项目将在西北大学举行，这是一个很好的培训环境，在那里（1） 是有价值且可访问的资源（例如设备，课程，讲习班），以及（2）赞助商和 共同发起人位于该机构，并在运动/神经科学领域具有专业知识（连接性 分析）和情感。培训计划：培训计划将包括学习理论，数据 收集/处理/分析和解释在第1年和第2年。此外，课程和职业 在整个奖项期间，发展将成为重点的主题。该奖项的培训是 当前的知识并提供了将新颖理论和方法整合到情感过程中的机会。