Sources, Transport, Exposure and Effects of PFASs (STEEP)

PFAS 的来源、传输、暴露和影响 (STEEP)

• 批准号: 9904670
• 负责人: Elsie Mareca Sunderland
• 金额: $ 20.18万
• 依托单位: UNIVERSITY OF RHODE ISLAND
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9904670
• 关键词: Address; Affect; Age; Alkanesulfonates; Anoxia; Antibody Formation; Area; Automobile Driving; Biological Markers; Carbon; Characteristics; Child; Chronic; Code; Cods; Collaborations; Detection; Environment; Environmental Risk Factor; Exposure to; Fingerprint; Fire - disasters; Fishes; Food Webs; Fresh Water; Gap Junctions; Geological Survey; Goals; Hazardous Waste Sites; Head; Health; Human; Immune; Immunologic Markers; Immunosuppression; Individual; Industrialization; Industry; Joints; Knowledge; Laboratories; Lead; Length; Link; Location; Malignant Neoplasms; Measurement; Measures; Metabolic; Metabolic Diseases; Metabolism; Methods; Military Personnel; Modeling; Outcome; Outcomes Research; Poison; Population; Positioning Attribute; Public Health; Research; Research Priority; Risk; Risk Assessment; Safety; Site; Source; Statistical Methods; Superfund; Time; Tissues; Toxicology; Toxoids; Tracer; Training; Training Activity; United States; Universities; Vaccines; Water; Water Supply; Work; base; chemical property; consumer product; contaminated drinking water; drinking water; exposed human population; exposure pathway; fighting; ground water; hydrology; immune function; immunotoxicity; improved; improved mobility; novel; obesity risk; persistent organic pollutants; population based; remediation; reproductive; response; response biomarker; superfund site; uptake; vector; virtual

PROJECT SUMMARY/ABSTRACT More than 600 sites across the U.S. are contaminated by poly and perfluroalkyl substances (PFASs) but the extent of transport away from these sites and entry into human exposure pathways (drinking water and fish) is virtually unknown. This information is critical for assessing human health risks associated with exposures to PFASs from contaminated sites, such as the metabolic and immune outcomes that are being investigated in Projects 2 and 3 of the STEEP Center. This project will measure a suite of PFASs present in drinking water and fish near the Joint Base Cape Cod (JBCC), a region contaminated by historical fire training activity and designated as a National Priorities List site. For Aim 1, novel statistical methods will be used to fingerprint profiles of PFASs measured in fish and drinking water around the JBCC site. PFAS profiles in drinking water and fish will be compared to those from consumer products (wastewater influent) to identify exposures originating from contaminated sites. For Aim 2, we will leverage from long-term research by the U.S. Geological Survey (USGS) near the JBCC site characterizing hydrological flow paths and groundwater geochemistry to better understand how environmental factors influence the transport and transformations of PFASs away from contaminated sites and into drinking water supplies. We will use a combination of field measurements in collaboration with Project 4, and advanced geochemical modeling that leverages from prior USGS hydrological research. For Aim 3, we will extend knowledge on the spatial domain of groundwater transport to include uptake by fish. Fish will be exposed to experimental incubations along the groundwater transport plume and we will assess toxicological biomarkers for immune and metabolic responses. One of the major expected outcomes of this work will be better understanding of the spatial extent of elevated PFAS concentrations in fish and drinking water from contaminated sites, which will allow improved characterization of exposed populations and risks. This project will provide a novel contribution at the nexus between geochemistry and health by linking the geochemical factors affecting PFAS transport and mobility to human health risks associated with exposure. !

项目摘要/摘要 美国各地有600多个地点被聚和氟烷基物质（PFASS）污染 但是，从这些地点和进入人类暴露途径的运输范围（饮酒） 水和鱼）几乎是未知的。此信息对于评估人类健康风险至关重要 与受污染部位的PFASS暴露有关，例如代谢和免疫 在陡峭中心的项目2和3中进行了调查的结果。这个项目将 测量在饮用水和鱼类联合基地Cod Cod（JBCC）附近存在的一套PFASS， 一个被历史消防活动污染的地区，并被指定为国家优先事项清单 地点。对于AIM 1，新型统计方法将用于测量的PFAS的指纹概况 在JBCC站点周围钓鱼和饮用水。饮用水和鱼类中的PFA概况将 与消费产品（废水影响力）相比 来自受污染的站点。对于AIM 2，我们将从美国地质的长期研究中利用 JBCC站点附近的调查（USGS）表征水文流道和地下水 地球化学以更好地了解环境因素如何影响运输和 PFASS从受污染的地点转变为饮用水供应。我们将 与项目4和高级地球化学合作使用现场测量的组合 建模从先前的USGs水文研究中利用这一点。对于目标3，我们将扩展 关于地下水运输的空间域的知识，包括鱼类的吸收。鱼会 暴露于沿地下水羽流的实验孵育，我们将评估 免疫和代谢反应的毒理学生物标志物。主要的预期结果之一 这项工作将更好地理解鱼类PFA浓度升高的空间程度 和受污染地点的饮用水，这将允许改善暴露的表征 人口和风险。该项目将在Nexus之间提供新颖的贡献 通过将影响PFA的运输和流动性的地球化学因素联系起来，地球化学和健康 与暴露有关的人类健康风险。 呢