Emotion Dysregulation and Sleep-Time Masticatory Muscle Activity in Sleep Bruxism

睡眠磨牙症中的情绪失调和睡眠时咀嚼肌活动

基本信息

批准号：
9905405
负责人：
JAMES J GROSS
金额：
$ 71.04万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-04-13 至 2022-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9905405
关键词：
Address Affective Ambulatory Monitoring Amygdaloid structure Brain region Clinical Cues Data Degenerative Disorder Development Diagnostics Research Disease Down-Regulation Emotional Emotions Enrollment Functional Magnetic Resonance Imaging Generations Goals Impairment Individual Joints Laboratories Lead Literature Masticatory muscles Measures Mood Disorders Movement Disorders Neurobiology Neurodegenerative Disorders Orofacial Pain Pain Participant Pathway interactions Patient Self-Report Polysomnography Prefrontal Cortex Process Randomized Research Role Sleep Sleep Bruxism Sleep Disorders Sleep disturbances Stress Temporomandibular Joint Testing Time Tooth structure Translational Research Work affective neuroscience base blood oxygen level dependent bone curative treatments effective therapy emotion dysregulation emotion regulation experimental group interest negative affect novel pre-clinical psychosocial development relating to nervous system response targeted imaging targeted treatment teeth clenching

项目摘要

PROJECT SUMMARY The overall goal of this proposal is to examine the role of emotion regulation (ER) in sleep bruxism (SB). SB is characterized by extreme levels of masticatory muscle activity (MMA) during sleep, expressed as teeth grinding or clenching. SB may proximally lead to tooth damage, orofacial pain, and impaired sleep; predispose to the development of joint degenerative disorders; and ultimately present a preclinical sign for a broader range of neurodegenerative disorders. However, there is as yet no curative treatment for SB, and the mechanisms underlying SB are not well understood. To fill this gap, we propose an integrative neurobiological framework that focuses on the involvement of impaired downregulation of wake-time emotion in SB. We will test basic tenets of this framework by addressing four major aims: Aim 1 tests differences in task-related neural activation during ER in individuals with SB (SB+) vs. matched controls (SB−). Aim 2 investigates direct and indirect pathways associating task- related prefrontal cortex activatin during ER with MMA during sleep among SB+ and SB−. Aim 3 examines whether neural activation during ER can be experimentally manipulated in SB+. Aim 4 addresses causal mechanisms by investigating whether more efficient task-related prefrontal cortex activation during ER decreases MMA during sleep in SB+ through decreased task-related emotional activation of the amygdala. 100 SB+ and 50 SB− will be defined based on polysomnographic research diagnostic criteria. Functional activations of brain regions of interest during an ER task will be assessed and ambulatory monitoring of MMA during sleep will be conducted. In SB+, ER will be experimentally manipulated and effects will be assessed on functional activations of brain regions of interest during the ER task as well as on MMA during sleep. The proposed work is part of a programatic translational research agenda to develop novel effective therapies that target ER processes to alleviate affective, sleep, and stress-induced neurodegenerative disorders.

项目摘要该提议的总体目标是检查情绪调节（ER）在睡眠磨牙症中的作用（SB）。 SB的特征是睡眠期间极高的咀嚼肌活动（MMA）水平表示为牙齿磨碎或握紧。 SB可能会导致牙齿损伤，口面疼痛和睡眠受损；倾向于发展关节退行性疾病；并最终提出临床前征兆，具有更广泛的神经退行性疾病。但是，尚无对SB的治疗治疗以及SB的基础机制尚不清楚。为了填补这个空白，我们提出了一个综合神经生物学框架，该框架着重于受损的参与 SB中的唤醒时间情绪下调。我们将通过解决此框架的基本原则四个主要目的：AIM 1测试在具有任务相关的神经激活的ER期间的差异 SB（SB+）与匹配的控件（SB-）。 AIM 2调查了关联任务的直接和间接途径 - SB+和SB-在睡眠期间与MMA相关的相关前额叶皮层activatin。目标3 检查在SB+中是否可以通过实验操纵ER期间的神经激活。目标4 通过研究是否有效率更高的任务相关前额叶皮质来解决因果机制 ER期间的激活通过改善任务相关的情绪在SB+的睡眠中降低MMA 杏仁核的激活。 100 SB+和50 SB-将根据多摄影研究定义诊断标准。将评估ER任务期间感兴趣的大脑区域的功能激活将在睡眠期间对MMA进行卧床监测。在SB+中，ER将进行实验操纵和效果将评估对感兴趣的大脑区域功能激活期间的功能激活急诊任务以及睡眠期间的MMA。拟议的工作是编程翻译的一部分研究议程，以开发针对ER过程以减轻情感的新型有效疗法，睡眠和压力引起的神经退行性疾病。